1015-37-8

Basic information

• Product Name: DIPHENYLPHOSPHINOTHIOYL CHLORIDE
• Synonyms: DIPHENYLPHOSPHINOTHIOYL CHLORIDE;diphenylphosphinothioic chloride;Chlorodiphenylphosphine sulfide;Diphenylchlorophosphine sulfide;Diphenylthiophosphinic acidchloride;Diphenylphosphinous
• CAS NO: 1015-37-8
• Molecular Formula: C₁₂H₁₀ClPS
• Molecular Weight: 252.7
• Mol File: 1015-37-8.mol

Chemical Properties

• Boiling Point: 355.3°Cat760mmHg
• Flash Point: 168.7°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 6.46E-05mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: DIPHENYLPHOSPHINOTHIOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DIPHENYLPHOSPHINOTHIOYL CHLORIDE(1015-37-8)
• EPA Substance Registry System: DIPHENYLPHOSPHINOTHIOYL CHLORIDE(1015-37-8)

Safety Data

• Hazardous Substances Data: 1015-37-8(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
DIPHENYLPHOSPHINOTHIOYL CHLORIDE is used as a reagent in the synthesis of organophosphorus compounds, which are essential in the production of insecticides and nerve agents. Its high reactivity makes it a valuable component in the creation of these compounds.
Used in Polymer Modification:
In the polymer industry, DIPHENYLPHOSPHINOTHIOYL CHLORIDE is used as a modifying agent to alter the properties of polymers, enhancing their performance and versatility in various applications.
Used in Catalyst Preparation:
DIPHENYLPHOSPHINOTHIOYL CHLORIDE is used as a precursor in the preparation of phosphorus-containing ligands, which are crucial for catalysis in chemical reactions. These ligands can improve the efficiency and selectivity of catalytic processes.
Used in Pharmaceutical and Agrochemical Industries:
DIPHENYLPHOSPHINOTHIOYL CHLORIDE is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Safety Precautions:
Due to its irritant properties and potential to cause lacrimation, DIPHENYLPHOSPHINOTHIOYL CHLORIDE should be handled with care. Appropriate safety measures, including the use of personal protective equipment and proper disposal methods, should be followed to minimize exposure and potential hazards.

InChI:InChI=1/C12H10ClPS/c13-14(15,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H

Upstream product

• 1015-38-9 diphenylphosphinodithioic acid 
• 462-06-6 fluorobenzene 
• 92-52-4 biphenyl 
• 1707-03-5 diphenyl-phosphinic acid 
• 20472-49-5 ethyl diphenylthiophosphinite 
• 107-14-2 chloroacetonitrile 
• 1079-66-9 chloro-diphenylphosphine 
• 545-06-2 trichloroacetonitrile 
• 19172-47-5 Lawessons reagent 
• 1499-21-4 Diphenylphosphinic chloride 
• 71-43-2 benzene 

Downstream Products

• 17366-80-2 P,P-diphenylphosphinothioic amide 
• 14278-72-9 diphenylthiophosphinic acid 
• 37909-46-9 diphenyl-phosphinothioic acid 3-anilino-4-phenyl-4H-[1,2,4]thiadiazol-5-ylideneamide 
• 109616-23-1 S-(1-Methyl-2-carbethoxy-vinyl)-diphenyl-dithiophosphinsaeureester 
• 24625-76-1 Diphenylthiophosphinigsaeure-<¹⁴C>-isothiocyanat 
• 3096-09-1 diphenylphosphinothioic O-acid anhydride 
• 2752-01-4 1,2-bis(diphenylthioylphosphino)hydrazine 
• 6854-23-5 N-Diphenylthiophosphinyl-N'-benzoyl-hydrazin 
• 24625-68-1 N-butyl-P,P-diphenylphosphinothioic amide 
• 62281-44-1 1-Butyl-1,2,2-triphenyldiphosphindisulfid 
• 68018-02-0 m-methoxyphenyl ester of diphenylthionephosphinic acid 
• 62246-72-4 O-Diphenylmethyldiphenylphosphinothioat 
• 68017-99-2 p-nitrophenyl diphenylphosphinothionate 
• 68018-05-3 O-p-tolyl diphenylphospinothioate 

Relevant articles and documents

DIPHENYL(PENTAFLUOROBENZOYLOXY)PHOSPHANOXID UND -SULFID

Diphenyl(pentafluorobenzoyloxy)phosphane chalcogenides (C6H6)2P(E)(OC(O)C6F5) were prepared by treating AgOC(O)C6F5 with (C6H5)2P(E)Cl ((1)H-, (19)F- und (31)P-NMR- und IR-data).Phosphino-thiono- or phosphino-thiolo-rearrangements are not observed under conditions of synthesis.

Imaging Hg2+-Induced Oxidative Stress by NIR Molecular Probe with "dual-Key-and-Lock" Strategy

Mercury (Hg) is considered an extremely toxic heavy metal which is extremely harmful to both the human body and environment. In addition, Hg2+-induced oxidative stress also exerts a crucial role to play in pathophysiological mechanisms of mercury toxicity

Bismuth(iii) Thiophosphinates: Understanding How a Small Atomic Change Influences Antibacterial Activity and Mammalian Cell Viability

Diphenylphosphinothioic acid (HSP(=O)Ph2) and diphenylphosphinodithioic acid (HSP(=S)Ph2) have been used to synthesise four BiIII complexes: 1 [Bi(SP(=O)Ph2)3], 2 [BiPh(SP(=O)Ph2)2], 3 [BiPh2(SP(=O)Ph2)], and 4 [Bi(SP(=S)Ph2)3], using BiPh3 and [Bi(OtBu)3] as bismuth sources. The complexes have been characterised by NMR spectroscopy, mass spectrometry, infrared spectroscopy, powder X-ray diffraction, and singe crystal X-ray crystallography (2-4). Biological studies indicated that despite complexes 2 and 3 reducing mammalian cell viability, their antibacterial activity provides a good degree of selectivity towards both Gram positive and Gram negative bacterial strains. The minimum inhibitory concentrations for complexes 2 and 3 are in the range of 0.52-5.5 μM towards the bacteria tested. Homoleptic complexes 1 and 4 were generally less active towards both bacterial and mammalian cells.

Benign and high-yielding, large-scale synthesis of diphenylphosphinodithioic acid and related compounds

Diphenylphosphinodithioic acid (6b) and its triethyl ammonium salt (6a) were prepared by two new synthetic pathways, each employing cheap and readily available starting materials. These facile one-pot reactions were conducted on a kilogram scale and produ

Reactivity of X3P compounds with elemental sulfur, carbon disulfide or both, to yield X3PS, X3RCS2 or X3P.Sn.CS2 adducts

Kinetic constants k2 have been obtained for the reaction of sulfur with 25 PIII compounds in toluene or hexane. In the series PhnMe3-nP (n = 1-3) or PhnBu3-nP (n = 0-3), log k2 decreases linearly with Σχi (χi=Tolman's electronic parameter of each ligand on P), taken as a gauge for the donor strength of P. Dramatic deviations from additivity are observed for the series PhnP(OEt)3-n, PhnP(OEt)3-n, and BunP(OEt)3-n(n = 0-3); the deviation is smaller for PhnPCl3-n, and even smaller for PhnP(NEt2)3-n . The results are discussed in terms of P-coordination (PIV vs. PV), stability and geometry of the intermediate X3P.S8 or of the transition state leading to this adduct, emphasis being laid on the donor/acceptor character of the P site. A similar dependence on X governs the reactivity of X3P with S8, CS2 or both, to give X3PS, X3P.CS2 (binary red adduct) or X3P.Sn.CS2 (ternary yellow adduct) respectively; an explanation for this parallelism is proposed.

N-(diphenylphosphinothioyl)hydroxylamine: Preparation, characterisation and base-induced transposition of sulfur and oxygen atoms in its O-benzoyl derivative

N-(Diphenylphosphinothioyl)hydroxylamine 5 has been prepared from Ph2P(S)Cl using H2NOSiMe3 and has been converted into its O-benzoyl derivative Ph2P(S)NHOCOPh 6. The principal reaction of the derivative 6 with base (NaOMe or ButNH2) is rearrangement, transposition of sulfur and oxygen giving Ph2P(O)NHSCOPh 7; this then reacts further, forming the phosphinic amide Ph2P(O)NH2 together with PhCO2Me or PhCONHBut. The rearrangement probably involves intramolecular nucleophilic displacement of benzoate by the P=S group of 6, forming an intermediate with P, N and S atoms in a three-membered ring.

ARYLIERUNG VON THIOPHOSPHORCHLORIDEN IN GEGENWART VON ALUMINIUM CHLORID

Differently substituted tertiary phosphine-sulfides are prepared in an one-pot-synthesis by reaction of PCl3 with benzene and sulfur via the intermediate phenylthiophosphonic-dichloride or by arylation of PSCl3 or organothiophosphonic-dichlorides via the isolable intermediates diorganothiophosphinic-chlorides.AlCl3 is used as catalyst.

Carboxydiphenyl Phosphane Sulfides

Carboxydiphenyl phosphane sulfides (C6H5)2P(S)(OC(O)R) (2) (R = CH3 2a, C2H5 2b, C17H35 2c, (CH3)3C 2d, C6H5 2e) were prepared by reacting silver salts of carboxylic acids AgOC(O)R with (C6H5)2P(S)Cl (Scheme 1) or by treating carboxylic acids with (C6H5)2P(S)Cl in the presence of triethyl amine (Scheme 2) and spectroscopically characterized.Thermal stability and stability against hydrolysis of the mixed anhydrides is unusually high. - Key words: Carboxydiphenyl Phosphane Sulfides, Thermal Stability

Reactions of the trisulfur trinitride anion, S3N3-, with halogens and other electrophilic substrates

The reactions of the trisulfur trinitride anion, S3N3-, with halogens (Cl2, Br2, I2), AsF5, SOCl2, SO2Cl2, S2Cl2, COCl2, CS2, Me3SiCl, and Ph2PCl have been investigated.In all cases these reactions gave mixtures of known sulfur-nitrogen compounds.Thus the halogens react with S3N3- to give mainly S4N4, S4N3+X- (X=Br, Cl), (SN)x, and S3N3X3 (X=Cl), while AsF5 oxidizes S3N3- to S4N4*AsF5.The major products of the reaction of S3N3- with SOCl2 or SO2Cl2 were S4N4, S4N3+Cl-, and (for SOCl2 only) S3N2O2.S3N2Cl was the main product of the reaction of S3N3- with S2Cl2, whereas COCl2 yielded (SN)x in addition to S3N2Cl and S4N4.Carbon disulfide reacts with S3N3- to give S4N2, S4N4, and CNS-.The cyclophosphathiazenes, (Ph2PN)(SN)2, 1,3- and 1,5-(Ph2PN)2(SN)2, in addition to (Ph2PN)x (x=3, 4), (Ph2PN)3*HCl and (Ph2PN)2NSCl were isolated from the reactions of Ph2PCl with S3N3- in various molar ratios.The latter reaction represents a useful alternative synthesis of the 1,5-isomer of the eight-membered ring (Ph2PN)2(SN)2.