120511-72-0 Usage
Description
3,5-Bis(2-cyanoprop-2-yl)toluene, also known as α,α,α',α'-Tetramethyl-5-methyl-1,3-benzenediacetonitrile, is an organic compound that serves as a crucial intermediate in the synthesis of Anastrozole, an aromatase inhibitor. It is characterized by its white solid appearance and plays a significant role in the pharmaceutical industry due to its contribution to the production of a vital antineoplastic agent.
Uses
Used in Pharmaceutical Industry:
3,5-Bis(2-cyanoprop-2-yl)toluene is used as a labeled intermediate for the synthesis of Anastrozole (A637425), an aromatase inhibitor. It is utilized for its antineoplastic properties, which are essential in the development and production of cancer-fighting drugs.
As an intermediate in the synthesis of Anastrozole, 3,5-Bis(2-cyanoprop-2-yl)toluene contributes to the creation of a medication that inhibits the aromatase enzyme, thereby reducing the production of estrogen in the body. This inhibition is particularly beneficial in the treatment of hormone receptor-positive breast cancer, as it helps to slow down or stop the growth of cancer cells that rely on estrogen for their development.
Check Digit Verification of cas no
The CAS Registry Mumber 120511-72-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,5,1 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 120511-72:
(8*1)+(7*2)+(6*0)+(5*5)+(4*1)+(3*1)+(2*7)+(1*2)=70
70 % 10 = 0
So 120511-72-0 is a valid CAS Registry Number.
120511-72-0Relevant articles and documents
An efficient synthesis of 3,5-bis(2-cyanoisopropyl)toluene
Mei, Yu-Hua,Luo, Yu,Lu, Wei
, p. 487 - 489 (2008)
-
Palladium-Catalyzed Allenamide Carbopalladation/Allylation with Active Methine Compounds
Zhu, Xiaoyi,Li, Ruibo,Yao, Hequan,Lin, Aijun
supporting information, p. 4630 - 4634 (2021/06/28)
A palladium-catalyzed allenamide carbopalladation/allylation with active methine compounds has been developed. Various indoles and isoquinolinones bearing a quaternary carbon center were achieved with good efficiency, a broad substrate scope and good functional group tolerance. This reaction underwent cascade oxidative addition, carbopalladation, and allylic alkylation, and two new C-C bonds were formed in one pot.
A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions
Huang, Binbin,Guo, Lin,Xia, Wujiong
supporting information, p. 2095 - 2103 (2021/03/26)
A general electrochemical system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an alcohol as a co-solvent.