140-76-1

Basic information

• Product Name: 2-Methyl-5-vinylpyridine
• Synonyms: 2,5-Methylvinylpyridine;2-Methyl-5-vinylpridine;2-Picoline, 5-vinyl-;5-Vinyl-2-picoline;Pyridine, 2-methyl-5-vinyl-;Pyridine, 5-ethenyl-2-methyl-;5-Vinyl-ALPHA-picoline;5-Ethenyl-2-methypyridine
• CAS NO: 140-76-1
• Molecular Formula: C₈H₉N
• Molecular Weight: 119.16
• EINECS: 205-432-5
• Mol File: 140-76-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: -12.0 °C
• Boiling Point: 212.46°C (rough estimate)
• Flash Point: 56.618 °C
• Appearance: Clear to faintly opalescent liquid
• Density: 1.0000 (rough estimate)
• Vapor Pressure: 1.535mmHg at 25°C
• Refractive Index: 1.5330 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.58±0.10(Predicted)
• CAS DataBase Reference: 2-Methyl-5-vinylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-5-vinylpyridine(140-76-1)
• EPA Substance Registry System: 2-Methyl-5-vinylpyridine(140-76-1)

Safety Data

• RIDADR: 2810
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 140-76-1(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 140-76-1 differently. You can refer to the following data:
1. Clear to faintly opalescent liquid. Combustible.
2. 2-Methyl-5-vinylpyridine is a clear to faintly opalescent liquid.

Uses

Monomer for resins, oil additive, ore flotationagent, dye acceptor.

General Description

Clear to faintly opalescent liquid. Used as a monomer for resins, as an oil additive, ore flotation agent; and dye acceptor.

Reactivity Profile

2-Methyl-5-vinylpyridine neutralizes acids in exothermic reactions to form salts plus water. Can polymerize exothermically. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

2-Methyl-5-vinylpyridine is moderately toxic by ingestion, inhalation, and absorption through the skin.

Fire Hazard

When heated to decomposition, 2-Methyl-5-vinylpyridine emits toxic fumes of nitrogen oxides. (Non-Specific -- Combustible Liquid, n.o.s.) Flammable/combustible material; may be ignited by heat, sparks, or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire.

Potential Exposure

2-Methyl-5-vinylpyridine is used as a monomer for resins; oil additive; ore flotation agent; and dye acceptor.

Shipping

UN3073 Vinylpyridines, stabilized, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3- Flammable liquid, 8-Corrosive material. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required.

Incompatibilities

Can polymerize exothermically. May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, hydrides and other strong reducing agents. 2-Methyl-5-vinylpyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

InChI:InChI=1/C8H9N/c1-3-8-5-4-7(2)9-6-8/h3-6H,1H2,2H3

Synthetic route

1-(6-methylpyridin-3-yl)ethanol maleate → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
Stage #1: 1-(6-methylpyridin-3-yl)ethanol maleate With thionyl chloride; sodium hydroxide In Isopropyl acetate Stage #2: With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 50℃; for 4h;	99%

5-bromo-2-methylpyridine (3430-13-5) + tri-n-butyl(vinyl)tin (7486-35-3) → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; N,N-dimethyl-formamide at 20 - 100℃; Inert atmosphere;	47%

5-ethyl-2-methyl-pyridine (104-90-5) → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
With cerium(IV) oxide; carbon dioxide at 700℃; Siliciumdioxid;
With carbon dioxide; tungsten(VI) oxide at 700℃; Siliciumdioxid;
With zinc oxide-chromium oxide-iron oxide-aluminium oxide; steam; potassium oxide at 600℃;
With chromium corundum at 600℃;

(+-)-1-<6-methyl-<3>pyridyl>-ethanol → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
With calcium hydrogen phosphate at 450℃;
With potassium hydrogensulfate at 230℃;

(+-)-1-acetoxy-1-<6-methyl-<3>pyridyl>-ethane → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
With acetone at 570℃; Pyrolysis;

5-ethyl-2-methyl-pyridine (104-90-5) + steam → 2-methyl-5-vinylpyridine (140-76-1) + 3-ethyl-pyridin; additional product: 3-methyl-pyridine + 3-vinyl-pyridin; additional product: 2-methyl-pyridine + 2,5-dimethyl-pyridin; additional product: pyridine

Conditions	Yield
at 580 - 600℃; Leiten ueber durch Kaliumoxid aktivierte Zinkoxid-Chromoxid-Eisenoxid-Aluminiumoxid-Katalysatoren;

5-ethyl-2-methyl-pyridine (104-90-5) → 2-methyl-5-vinylpyridine (140-76-1) + pyridine-3-carbonitrile (100-54-9) + 5-ethyl-pyridine-2-carbonitrile (14178-13-3) + 2-cyano-5-vinylpyridine

Conditions	Yield
With ammonia; water; oxygen; vanadia; titanium(IV) oxide at 380℃; Product distribution; Further Variations:; reaction times;

2-methyl-5-formylpyridine (53014-84-9) + Methyltriphenylphosphonium bromide (1779-49-3) → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In diethyl ether at 5℃; for 1h; Stage #2: 2-methyl-5-formylpyridine In diethyl ether at 10℃; for 0.5h; Solvent;	38.2 g
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; Stage #2: 2-methyl-5-formylpyridine In tetrahydrofuran; hexane at 0 - 20℃;

2-methyl-5-vinylpyridine sesqui-oxalate → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
With potassium hydroxide In tert-butyl methyl ether; water pH=~ 14; Product distribution / selectivity;

5-bromo-2-methylpyridine (3430-13-5) + potassium vinyltrifluoroborate → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
With caesium carbonate; triphenylphosphine In water at 75 - 80℃; for 19h; Inert atmosphere;
With caesium carbonate; triphenylphosphine In water at 75 - 80℃; for 19h; Inert atmosphere;
With caesium carbonate; triphenylphosphine In water at 75 - 80℃; for 19h; Inert atmosphere;

2-methyl-5-vinylpyridinium DL-hydrogentartrate → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
With sodium hydroxide In tert-butyl methyl ether; water at 21 - 24℃; for 0.5h;

5-bromo-2-methylpyridine (3430-13-5) → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: butyl magnesium bromide; methyllithium / tetrahydrofuran / 0.5 h / -10 - 0 °C 1.2: 1 h 1.3: 1 h / 40 °C 2.1: thionyl chloride; sodium hydroxide / Isopropyl acetate 2.2: 4 h / 50 °C View Scheme

6-methyl-3-pyridinemethanol (34107-46-5) → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: Chloro-oxo-acetic acid; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C 1.2: 2.5 h / -78 °C 1.3: -78 - 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C 2.2: 0 - 20 °C View Scheme

Methyl 6-methylnicotinate (5470-70-2) → 2-methyl-5-vinylpyridine (140-76-1)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / diethyl ether; toluene / 1.5 h / 20 °C / Inert atmosphere; Reflux 1.2: 0 °C 2.1: Chloro-oxo-acetic acid; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C 2.2: 2.5 h / -78 °C 2.3: -78 - 20 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C 3.2: 0 - 20 °C View Scheme

2-methyl-5-vinylpyridine (140-76-1) + iodobenzene (591-50-4) → 2-methyl-5-phenethylpyridine (157993-44-7)

Conditions	Yield
With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In tetrahydrofuran at 50℃; for 3h;	99%

2-methyl-5-vinylpyridine (140-76-1) + allyl bromide (106-95-6) → 1-allyl-2-methyl-5-vinylpyridinium bromide

Conditions	Yield
With 10H-phenothiazine In acetonitrile at 20℃; for 24h; Alkylation;	91%

2-methyl-5-vinylpyridine (140-76-1) + diphenylphosphane (829-85-6) → 5-[2-(diphenylphosphino)ethyl]-2-methylpyridine

Conditions	Yield
With tetrakis(triethylphosphite)nickel(0); triethylamine In toluene at 130℃; for 20h;	90%
With Ni[P(OEt)3]4; triethylamine In benzene at 130℃; for 20h;	90%

2-methyl-5-vinylpyridine (140-76-1) + epichlorohydrin (106-89-8) → 1-(2,3-epoxypropyl)-2-methyl-5-vinylpyridinium chlride

Conditions	Yield
With hydroquinone In water; acetone at 20℃; for 120h; Alkylation;	89%

2-methyl-5-vinylpyridine (140-76-1) + bis(trimethylsilyl)phosphonite (30148-50-6) → C14H28NO2PSi2 (188935-62-8)

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) at 100 - 130℃;	89%

2-methyl-5-vinylpyridine (140-76-1) + 4β-[2-(N-acetylamino)-5-iodobenzoyloxy]-1α,14α,16β-trimethoxy-20-ethylaconitane-8,9-diol (941601-16-7) → (E)-4β-{2-acetylamino-5-[2-(6-methylpyridin-3-yl)ethenyl]}benzoyloxy-20-ethyl-1α,14α,16β-trimethoxyaconitane-8,9-diol

Conditions	Yield
With triethylamine; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 100℃; for 4h; Heck reaction;	86%

2-methyl-5-vinylpyridine (140-76-1) → 6-methylnicotinic acid (3222-47-7)

Conditions	Yield
With potassium permanganate In water at 80℃; for 0.05h;	84.2%
With potassium hydroxide; potassium permanganate In water; acetone at 30℃; for 2h; Title compound not separated from byproducts;

2-methyl-5-vinylpyridine (140-76-1) + buta-1,3-diene (106-99-0) → 2-methyl-5-(3-cyclohexenyl)pyridine

Conditions	Yield
With zirconocene dichloride In benzene at 150℃; for 4h;	80%

2-methyl-5-vinylpyridine (140-76-1) + acrylic acid (79-10-7) → 3-(2-methyl-5-vinyl-1-pyridinio)propionate

Conditions	Yield
With hydroquinone In water at 15 - 80℃; for 72h; Alkylation;	80%

2-methyl-5-vinylpyridine (140-76-1) + 2.8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (19686-05-6) → dimebon (3613-73-8)

Conditions	Yield
With potassium phosphate In ISOPROPYLAMIDE at 100℃; for 24h; Inert atmosphere;	80%
With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 100℃;	55%
With potassium hydroxide In diethylene glycol dimethyl ether at 120℃; for 42h; Product distribution / selectivity;	52%
With sodium ethanolate; sodium In dimethyl sulfoxide at 90 - 95℃;
With potassium phosphate In ISOPROPYLAMIDE at 130℃;

2-methyl-5-vinylpyridine (140-76-1) + divinyl sulfide (627-51-0) → polymer, with 96.04% of 2-methyl-5-vinylpyridine units and 3.97% of divinyl sulfide units; monomer(s): divinyl sulfide; 2-methyl-5-vinylpyridine

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) In N,N-dimethyl-formamide at 60℃;	79%

2-methyl-5-vinylpyridine (140-76-1) + p-toluidine (106-49-0) → 4-methyl-N-(2-(6-methylpyridin-3-yl)ethyl)aniline (21241-10-1)

Conditions	Yield
With sodium at 100℃; for 7h;	78%

2-methyl-5-vinylpyridine (140-76-1) + bis(2-phenylethyl)phosphine oxide (27440-52-4) → 5-[2-(Diphenethyl-phosphinoyl)-ethyl]-2-methyl-pyridine (209742-25-6)

Conditions	Yield
With potassium hydroxide; water; dimethyl sulfoxide; hydroquinone at 60℃; for 4h;	74%

2-methyl-5-vinylpyridine (140-76-1) → bis[2-(4-methyl-3-pyridyl)ethyl]phosphine (149672-64-0)

Conditions	Yield
With potassium hydroxide; hydrogen; phosphan; hydroquinone In water; dimethyl sulfoxide at 60℃; for 2.5h;	73%
With potassium hydroxide; hydrogen; phosphan In dimethyl sulfoxide at 45℃;	70%
With phosphorus

2-methyl-5-vinylpyridine (140-76-1) → Pyridine-2,5-dicarboxylic acid (100-26-5)

Conditions	Yield
With potassium permanganate In water at 98℃; for 3.15h;	72.4%

2-methyl-5-vinylpyridine (140-76-1) + methyl 2-(N-acetylamino)-5-iodobenzoate (208659-18-1) → methyl (E)-2-(acetylamino)-5-[2-(6-methylpyridin-3-yl)ethenyl]benzoate

Conditions	Yield
With triethylamine; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 100℃; for 4h; Heck reaction;	72%
Heck reaction;

2-methyl-5-vinylpyridine (140-76-1) + C27H26INO6 (1039433-18-5) → C35H34N2O6 (1062211-55-5)

Conditions	Yield
With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate In N,N-dimethyl-formamide at 150℃; Heck reaction;	71%

2-methyl-5-vinylpyridine (140-76-1) + 2,3-dicyclopropyl-1,3-butadiene (80393-10-8) → 5-(3,4-Dicyclopropyl-cyclohex-3-enyl)-2-methyl-pyridine

Conditions	Yield
With zirconocene dichloride In benzene at 150℃; for 4h;	70%

2-methyl-5-vinylpyridine (140-76-1) + 2,3-dimethyl-buta-1,3-diene (513-81-5) → 5-(3,4-Dimethyl-cyclohex-3-enyl)-2-methyl-pyridine

Conditions	Yield
With zirconocene dichloride In benzene at 150℃; for 4h;	70%

2-methyl-5-vinylpyridine (140-76-1) + (diisopropoxyphosphinoyl)formhydroximoyl chloride (127933-57-7) → 3-(diisopropoxyphosphinoyl)-5-(2-methylpyridin-5-yl)isoxazoline

Conditions	Yield
With triethylamine In diethyl ether for 1h; Ambient temperature;	69%

2-methyl-5-vinylpyridine (140-76-1) → bis[2-(4-methyl-3-pyridyl)ethyl]phosphinic acid (149672-62-8) + tris[2-(4-methyl-3-pyridyl)ethyl]phosphine oxide

Conditions	Yield
With potassium hydroxide; hydrogen; phosphan In water; dimethyl sulfoxide at 48 - 50℃; for 5h;	A 68% B 5%

2-methyl-5-vinylpyridine (140-76-1) + naphthalene-2-carboxylate (93-09-4) → C19H17NO

Conditions	Yield
With 2,4,6-trimethyl-pyridine; methylene blue; triphenylphosphine In N,N-dimethyl acetamide at 20℃; Inert atmosphere; Irradiation;	68%

2-methyl-5-vinylpyridine (140-76-1) + C25H24INO5 (1039433-14-1) → C33H32N2O5 (1062211-52-2)

Conditions	Yield
With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate In N,N-dimethyl-formamide at 150℃; Heck reaction;	67%

2-methyl-5-vinylpyridine (140-76-1) + 2,9-dimethyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole (1009631-54-2) → 2,9-dimethyl-6-[2-(6-methylpyridin-3-yl)ethyl]-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole (1009631-99-5)

Conditions	Yield
With tetrabutylammonium sulfate; potassium hydroxide In water; dimethyl sulfoxide at 80℃;	65%

2-methyl-5-vinylpyridine (140-76-1) → tris[2-(4-methyl-3-pyridyl)ethyl]phosphine oxide

Conditions	Yield
With phosphorus; potassium hydroxide; water; hydroquinone In dimethyl sulfoxide at 90 - 95℃; for 3h;	47%
Multi-step reaction with 2 steps 1: 70 percent Turnov. / PH3, H2, hydroquinone, KOH / dimethylsulfoxide; H2O / 0.5 h / 65 - 67 °C 2: 100 percent / air / 0.5 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: 28 percent / PH3, H2, hydroquinone, KOH / dimethylsulfoxide; H2O / 6 h / 65 - 67 °C 2: 100 percent / air / 0.5 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: 4 percent / P, KOH, hydroquinone, H2O / dimethylsulfoxide / 1 h / 90 °C / Irradiation 2: 100 percent / O2 / 24 h View Scheme

2-methyl-5-vinylpyridine (140-76-1) + 6-(methoxycarbonyl)-7-(trifluoromethylsulfonyloxy)-2H-chromen-2-one (1400766-72-4) → (E)-6-(methoxycarbonyl)-7-[2-(6-methylpyridin-3-yl)vinyl]-2Н-chromen-2-one (1400766-81-5)

Conditions	Yield
With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine In N,N-dimethyl-formamide at 135 - 140℃; for 16h; Heck Reaction; Inert atmosphere;	43%

2-methyl-5-vinylpyridine (140-76-1) → bis[2-(4-methyl-3-pyridyl)ethyl]phosphine (149672-64-0) + bis[2-(4-methyl-3-pyridyl)ethyl]phosphinic acid (149672-62-8) + 2-Methyl-5-(2-phosphanyl-ethyl)-pyridine

Conditions	Yield
With potassium hydroxide; hydrogen; phosphan In dimethyl sulfoxide at 35 - 40℃; for 6h;	A 38% B 5% C 24%

2-methyl-5-vinylpyridine (140-76-1) + 2-isopropyl-7-oxo-7H-furo[3,2-g]chromen-3-yl trifluoromethanesulfonate (1332511-78-0) → 2-isopropyl-3-[(E)-2-(4-methylpyridin-3-yl)vinyl]-7H-furo[3,2-g]chromen-7-one (1332511-90-6)

Conditions	Yield
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 115℃; for 8h; Heck reaction; Inert atmosphere;	38%

Upstream product

• 5470-70-2 Methyl 6-methylnicotinate 
• 34107-46-5 6-methyl-3-pyridinemethanol 
• 3430-13-5 5-bromo-2-methylpyridine 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 53014-84-9 2-methyl-5-formylpyridine 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 104-90-5 5-ethyl-2-methyl-pyridine 

Downstream Products

• 30456-59-8 2-Methyl-5-(2-methyl-cyclohex-3-enyl)-pyridine 
• 30456-62-3 2-Methyl-5-(5-methyl-cyclohex-3-enyl)-pyridine 
• 30456-53-2 2-methyl-5-(4-methyl-cyclohex-3-enyl)-pyridine 
• 104-90-5 5-ethyl-2-methyl-pyridine 
• 56019-64-8 5-(1-hydroxyethyl)-2-methylpyridine 
• 100189-17-1 2-(6-methylpyridin-3-yl) ethan-1-ol 
• 3222-47-7 6-methylnicotinic acid 
• 100-26-5 Pyridine-2,5-dicarboxylic acid 
• 157993-44-7 2-methyl-5-phenethylpyridine 
• 21241-08-7 2-methyl-5-{2-[1-(4-methylphenyl)hydrazinyl]ethyl}pyridine 
• 1402851-35-7 C₇₅H₉₀N₆OP₄ 
• 1402851-49-3 tris{4-[(2-bis[2-(6-methylpyrid-3-yl)ethyl]phosphoryl)ethyl]benzyl}phosphine oxide 
• 1309975-95-8 dimethyl 8-[(E)-4-acetylamino-3-(methoxycarbonyl)styryl]-3-(4-methoxybenzoyl)-5-methylindolizine-1,2-dicarboxylate 

Related news

Spectrophotometric titration of copolymers of 2-Methyl-5-vinylpyridine (cas 140-76-1) and acrylic acid07/15/2019

Copolymers of 2-methyl-5-vinylpyridine with acrylic acid have been studied by spectrophotometric titration in the UV region. It was found that the basic strength of the methylvinylpyridine groups increases as the proportion of acrylic acid units in the copolymer is increased, and the molar extin...detailed

Plasma-induced graft polymerisation of 2-Methyl-5-vinylpyridine (cas 140-76-1) on the surface of poly(ethylene terephthalate) track membranes07/13/2019

A process of the graft polymerisation of 2-methyl-5-vinylpyridine induced by plasma on the surface of poly(ethylene terephthalate) track membranes (PET TM) was investigated. The surface properties and hydrodynamic properties of the composite membranes produced in this case have been studied. It ...detailed

Synthesis, properties and mechanism of the ion exchange resins based on 2-Methyl-5-vinylpyridine (cas 140-76-1) and divinylbenzene in the catalytic disproportionation of trichlorosilane07/12/2019

The variety of catalysts based on macroporous ion exchange resins using 2-methyl-5-vinylpyridine cross-linked with divinylbenzene (2M5VP/DVB) was investigated in the disproportionation of trichlorosilane (TCS) in a continuous-flow reactor. The effects of the reaction temperature and surface area...detailed

Relevant articles and documents

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2-METHYL-5-VINYLPYRIDINIUM SALTS

Disclosed are novel salts of 2-methyl-5-vinylpyridine (MVP), such as hydrogentartrates, bromide, and dihydrogenphosphate. In contrast to the free base, these salts are crystalline and stable and can be safely stored and transported. The salts can also be used to purify MVP, in particular to reduce its content of 5-ethyl-2-methylpyridine and unwanted isomers.

AZA-RING FUSED INDOLE AND INDOLINE DERIVATIVES

The present application relates to indole and indoline derivatives of formula (I) wherein a, R1, m, L, and Q are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions of such compounds.