149-32-6 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 149-32-6 differently. You can refer to the following data:
1. Erythritol (meso-erythritol, meso-1,2,3,4-Tetrahydroxybutan) has been
known for a long time. Its potential use as a bulk sweetener was, however, recognized
rather late.
Erythritol is a natural constituent of several foods and beverages in levels
sometimes exceeding 1 g/kg. Its solubility in water is approximately 370 g/L at
room temperature and increases with increasing temperature. Erythritol melts at
121 C and is stable up to more than 160 C and in a pH range from 2 to 10.
Depending on the concentration used, erythritol is approximately 60 % as sweet
as sucrose. It is noncariogenic and not metabolized in the human body which
means that it is more or less calorie-free.
In the European Union, erythritol is approved as E 968 for a large number of
food applications. It is GRAS in the United States and also approved
in many other countries.
2. Erythritol is a sugar alcohol (polyol) that occurs as a white or almost
white powder or granular or crystalline substance. It is pleasant
tasting with a mild sweetness approximately 60–70% that of
sucrose. It also has a high negative heat of solution that provides a
strong cooling effect.
Characteristics
The sweetness of erythritol is low, the sweetness of erythritol is only 60%-70% of sucrose, the entrance has a cool taste, the taste is pure, and there is no post-bitterness. It can be used in combination with high-intensity sweeteners to inhibit its Undesirable flavors of high-intensity sweeteners. Erythritol has high stability, is very stable to acid and heat, and has high acid and alkali resistance. It will not decompose and change at temperatures below 200 °C, and will not undergo Maillard reaction to cause discoloration. The heat of dissolution of erythritol is high: erythritol has an endothermic effect when dissolved in water, and the heat of dissolution is only 97.4kJ/kg, which is higher than the endothermic degree of glucose and sorbitol, and has a cooling feeling when eating. The solubility of erythritol at 25 °C is 37% (W/W). With the increase of temperature, the solubility of erythritol increases, and it is easy to crystallize and separate out crystals. Erythritol is very easy to crystallize, but it will not absorb moisture in a 90% humidity environment. It is easy to be crushed to obtain a powdery product, which can be used on the surface of food to prevent food from absorbing moisture and deteriorating.
Uses
Different sources of media describe the Uses of 149-32-6 differently. You can refer to the following data:
1. Erythritol is a sweetener (polyol) manufactured by fermentation of
glucose, the glucose-rich substrate being obtained by the enzymatic
hydrolysis of starch. it is 60–70% as sweet as sugar, has excellent
heat and acid stability, a high digestive tolerance, and a caloric
value of 0.2 kcal/g. it is the only polyol produced by fermentation.
it can be used as a sugar replacement in confectioneries, beverages,
and desserts.
2. non-cariogenic, low-calorie (0.4 kcal/g) sweetener
3. Non-nutritive sweetener in beverages.
Definition
ChEBI: The meso-diastereomer of butane-1,2,3,4-tetrol.
Production Methods
Erythritol is a starch-derived product. The starch is enzymatically
hydrolyzed into glucose which is turned into erythritol via a
fermentation process, using osmophilic yeasts or fungi (e.g.
Moniliella pollinis, or Trichosporonoides megachiliensis).
Biotechnological Production
The synthesis of erythritol is rather difficult. One of the possibilities is the catalytic
reduction of tartaric acid with Raney nickel, which does, however, also produce
threitol, a diastereomere of erythritol that requires separation of both. Threitol may
be isomerized which increases the yields of erythritol. Another chemical synthesis
starts from butane-2-diol-1.4 which is reacted with chlorine in aqueous alkali to
yield erythritol-2-chlorohydrin and can be hydrolyzed with sodium carbonate solution. Synthesis from dialdehyde starch in the presence of a nickel catalyst at
high temperatures is also possible.
Owing to the special physiological properties of erythritol, commercial interest
increased with the discovery of an increasing number of microorganisms able to
produce this substance. Today, the commercial production of erythritol is apparently
only based on fermentation.
Erythrytitol fermentations mostly use osmophilic yeasts. Based on regulatory
submissions for commercial production, T. megachiliensis, M. pollinis, and
Y. lipolytica are used. It is also claimed that P. tsukubaensis and Aureobasidium
sp. are used for commercial production.
Erythritol-producing microorganisms often produce other polyols such as
ribitol. Nevertheless, some strains had a rather high yield of erythritol. A two-step
fermentation of C. magnoliae on 400 g/L glucose resulted in a 41 % conversion
rate and a productivity of 2.8 g/Lh. M. pollinis cultivated on glucose and
several nitrogen sources yielded erythritol concentrations up to 175 g/L with a
conversion rate of 43 %. Oxygen limitation resulted in ethanol formation, and
nitrogen limitation in strong foaming. A mutant gave even better yields.
Aerobically on glucose cultured P. tsukubaensis KN 75 produced 245 g/L of
erythritol with an especially high yield of 61 %. The productivity was 2.86 g/Lh.
Scale-up from 7-L laboratory fermenter to 50,000-L industrial scale resulted in
productivities similar to the laboratory value.
General Description
meso-Erythritol, belonging to the class of sugar alcohols, is identified in a variety of food products, fruits, vegetables, beverages and dietary supplements. It is known as a low glycemic food additive and plays an important role as a sweetener for diabetic patients, since it does not have glycemic or insulinemic effect due to its ability to not get metabolized but get absorbed in the small intestine. It is also reportedly used as a sugar substitute in toothpaste, chewing gums, confectionery food products, etc.
Flammability and Explosibility
Notclassified
Pharmaceutical Applications
Erythritol is a naturally occurring noncariogenic excipient used in a
variety of pharmaceutical preparations, including in solid dosage
forms as a tablet filler, and in coatings. It has also been
investigated for use in dry powder inhalers.It is also used in
sugar-free lozenges,and medicated chewing gum.Erythritol can also be used as a diluent in wet granulation in
combination with moisture-sensitive drugs. In buccal applications,
such as medicated chewing gums, it is used because of its high
negative heat of solution which provides a strong cooling effect.
Erythritol is also used as a noncaloric sweetener in syrups; it is
used to provide sensorial profile-modifying properties with intense
sweeteners; and it is also used to mask unwanted aftertastes.
Erythritol is also used as a noncariogenic sweetener in toothpastes
and mouthwash solutions.
Biochem/physiol Actions
Allelic variation of the Tas1r3 gene affects behavioral taste responses to this sugar alcohol, suggesting that it is a T1R3 receptor ligand.
Safety
Erythritol is used in oral pharmaceutical formulations, confectionery,
and food products. It is generally regarded as a nontoxic,
nonallergenic, and nonirritant material. However, there has been
a case report of urticaria caused by erythritol.
The low molecular weight of erythritol allows more than 90% of
the ingested molecules to be rapidly absorbed from the small
intestine; it is not metabolized and is excreted unchanged in the
urine. Erythritol has a low caloric value (0.8 kJ/g). The WHO has
set an acceptable daily intake of ‘not specified’ for erythritol.
Erythritol is noncariogenic; preliminary studies suggest that it
may inhibit the formation of dental plaque.
In general, erythritol is well-tolerated; furthermore,
excessive consumption does not cause laxative effects. There is no
significant increase in the blood glucose level after oral intake, and
glycemic response is very low, making erythritol suitable for
diabetics.
LD50 (mouse, IP): 8–9 g/kg
LD50 (rat, IV): 6.6 g/kg
LD50 (rat, oral): >13 g/kg
storage
Erythritol has very good thermal and chemical stability. It is
nonhygroscopic, and at 25°C does not significantly absorb
additional water up to a relative humidity (RH) of more than
80%. Erythritol resists decomposition both in acidic and alkaline
media and remains stable for prolonged periods at pH 2–10.(10)
When stored for up to 4 years in ambient conditions (20°C, 50%
RH) erythritol has been shown to be stable.
Purification Methods
meso-Erythritol crystallises from distilled water or absolute EtOH and is dried at 60o in a vacuum oven. It sublimes at 110o in a high vacuum. It is optically inactive. [Jeans & Hudson J Org Chem 20 1565 1955, IR: Kuhn Anal Chem 22 276 1950, Beilstein 1 IV 2807.]
Incompatibilities
Erythritol is incompatible with strong oxidizing agents and strong
bases.
Check Digit Verification of cas no
The CAS Registry Mumber 149-32-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 149-32:
(5*1)+(4*4)+(3*9)+(2*3)+(1*2)=56
56 % 10 = 6
So 149-32-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2
149-32-6Relevant articles and documents
Selective and Scalable Synthesis of Sugar Alcohols by Homogeneous Asymmetric Hydrogenation of Unprotected Ketoses
Tindall, Daniel J.,Mader, Steffen,Kindler, Alois,Rominger, Frank,Hashmi, A. Stephen K.,Schaub, Thomas
supporting information, p. 721 - 725 (2020/10/19)
Sugar alcohols are of great importance for the food industry and are promising building blocks for bio-based polymers. Industrially, they are produced by heterogeneous hydrogenation of sugars with H2, usually with none to low stereoselectivities. Now, we present a homogeneous system based on commercially available components, which not only increases the overall yield, but also allows a wide range of unprotected ketoses to be diastereoselectively hydrogenated. Furthermore, the system is reliable on a multi-gram scale allowing sugar alcohols to be isolated in large quantities at high atom economy.
Product Control and Insight into Conversion of C6 Aldose Toward C2, C4 and C6 Alditols in One-Pot Retro-Aldol Condensation and Hydrogenation Processes
Gao, Lou,Hou, Wenrong,Hui, Yingshuang,Tang, Yi,Zhan, Yulu,Zhang, Yahong
, p. 560 - 566 (2021/06/25)
Alcohols have a wide range of applicability, and their functions vary with the carbon numbers. C6 and C4 alditols are alternative of sweetener, as well as significant pharmaceutical and chemical intermediates, which are mainly obtained through the fermentation of microorganism currently. Similarly, as a bulk chemical, C2 alditol plays a decisive role in chemical synthesis. However, among them, few works have been focused on the chemical production of C4 alditol yet due to its difficult accumulation. In this paper, under a static and semi-flowing procedure, we have achieved the product control during the conversion of C6 aldose toward C6 alditol, C4 alditol and C2 alditol, respectively. About C4 alditol yield of 20 % and C4 plus C6 alditols yield of 60 % are acquired in the one-pot conversion via a cascade retro-aldol condensation and hydrogenation process. Furthermore, in the semi-flowing condition, the yield of ethylene glycol is up to 73 % thanks to its low instantaneous concentration.
START-UP PROCESS FOR THE PRODUCTION OF GLYCOLS
-
Paragraph 0056-0057, (2020/05/07)
The invention provides a start-up method for a process for the preparation of glycols from a starting material comprising one or more saccharides in the presence of hydrogen and a catalyst system comprising one or more retro-aldol catalysts comprising tungsten and one or more catalytic species suitable for hydrogenation in a reactor, said method comprising introducing the one or more retro-aldol catalysts to the reactor whilst also in the presence of one or more agents suitable to suppress tungsten precipitation.
Xi:Irritant;
