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1-Phenyl-3-guanylthiourea is an organic compound with the chemical formula C8H10N4S. It is a derivative of thiourea, which is a sulfur-containing compound known for its various applications in the chemical and rubber industries. The presence of the phenyl group and guanyl moiety in its structure contributes to its unique properties and reactivity.

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  • 15989-47-6 Structure
  • Basic information

    1. Product Name: 1-PHENYL-3-GUANYLTHIOUREA
    2. Synonyms: 1-AMIDINO-3-PHENYLUREA;1-PHENYL-3-GUANYLTHIOUREA;Phenylguanylthiourea;1-PHENYL-3-GUANYLTHIOUREA 98+%;[({[Amino(imino)methyl]amino}carbothioyl)amino]benzene
    3. CAS NO:15989-47-6
    4. Molecular Formula: C8H10N4S
    5. Molecular Weight: 194.26
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 15989-47-6.mol
  • Chemical Properties

    1. Melting Point: 169°C
    2. Boiling Point: 364.2°C at 760 mmHg
    3. Flash Point: 174°C
    4. Appearance: /
    5. Density: 1.34g/cm3
    6. Vapor Pressure: 1.72E-05mmHg at 25°C
    7. Refractive Index: 1.672
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 1-PHENYL-3-GUANYLTHIOUREA(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-PHENYL-3-GUANYLTHIOUREA(15989-47-6)
    12. EPA Substance Registry System: 1-PHENYL-3-GUANYLTHIOUREA(15989-47-6)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 36/37/38-22
    3. Safety Statements: 26-36/37/39
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 15989-47-6(Hazardous Substances Data)

15989-47-6 Usage

Uses

Used in Rubber Industry:
1-Phenyl-3-guanylthiourea is used as a secondary accelerator for the vulcanization of natural rubber. It plays a crucial role in the rubber manufacturing process by accelerating the vulcanization reaction, which is responsible for the cross-linking of rubber polymers. This cross-linking process enhances the rubber's strength, elasticity, and durability, making it suitable for various applications such as tires, hoses, and other rubber products.

Check Digit Verification of cas no

The CAS Registry Mumber 15989-47-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,9,8 and 9 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 15989-47:
(7*1)+(6*5)+(5*9)+(4*8)+(3*9)+(2*4)+(1*7)=156
156 % 10 = 6
So 15989-47-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N4S/c9-7(10)12-8(13)11-6-4-2-1-3-5-6/h1-5H,(H5,9,10,11,12,13)

15989-47-6 Well-known Company Product Price

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  • TCI America

  • (P1167)  1-Phenyl-3-guanylthiourea  

  • 15989-47-6

  • 5g

  • 2,700.00CNY

  • Detail

15989-47-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Phenyl-3-guanylthiourea

1.2 Other means of identification

Product number -
Other names 1-Amidino-3-phenylthiourea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15989-47-6 SDS

15989-47-6Relevant articles and documents

Co-Catalyzed Intramolecular S-N Bond Formation in Water for 1,2-Benzisothiazol-3(2H)-ones and 1,2,4-Thiadiazoles Synthesis

Yang, Liting,Song, Lijuan,Tang, Shanyu,Li, Longjia,Li, Heng,Yuan, Bingxin,Yang, Guanyu

, p. 1281 - 1285 (2019/01/14)

An efficient and versatile Co-catalyzed intramolecular S-N bond formation in water to synthesize 1,2-benzisothiazol-3(2H)-one and 1,2,4-thiadiazoles derivatives in good to excellent yields was developed. The transformation showed great tolerance with a broad range of substituents. The mother liquor was able to be recycled 6 times with minor loss in product yield.

Synthesis of 5-Amino and 3,5-Diamino Substituted 1,2,4-Thiadiazoles by I2-Mediated Oxidative N-S Bond Formation

Wang, Bingnan,Meng, Yinggao,Zhou, Yiming,Ren, Linning,Wu, Jie,Yu, Wenquan,Chang, Junbiao

, p. 5898 - 5903 (2017/06/07)

An oxidative N-S bond formation reaction has been established for 1,2,4-thiadiazole synthesis employing molecular iodine as the sole oxidant. The features of the present reaction include no use of transition metals, mild reaction conditions, simple operat

NOVEL FLAVONE BASED EGFR INHIBITORS AND PROCESS FOR PREPARATION THEREOF

-

Page/Page column 14, (2016/09/22)

The present invention discloses a novel EGFR inhibitor compound of formula (1), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (1). wherein, R is selected from hydrogen, alkyl, nitro, halogens such as chlorine, bromine, fluorine and iodine; Rl= hydrogen, alkyl, alkoxy, aryl, nitro, halogens such as chlorine, bromine, fluorine and iodine, trifluoromethyl, thioalkyl, trifluromethoxy, trialkylsilyl.

NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS

-

, (2016/06/15)

The present invention disclosed a novel EGFR inhibitor compound of formula (I), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (I). Wherein, R= -H, 3-CH3, 4-NO2, 4-Cl, 2-CH3, 4-CH3, 4-Br, 4-F R1= -H, -4-OCH3, -4-NO2,-2-NO2, -4-Cl, -2,4,6-CH3, -4-CH3, -2-F,4-Br, -4-CF3, -4-S-CH3, -4-Cl,-3-CF3, -3-S-CH3, -3,5-CF3, -2-S-CH3, -3-CF3,-4-OCF3, -Si-(CH3)3, -Si-(C2H5)3, (CH3)2-Si- C2H5.

Studies in the antimicrobial activities of 1-substituted-3-formamidinothio- carbamides and 1,3-bis-(substitutedthioamido)guanidines

Waghmare,Tayade,Shelke,Patil

, p. 819 - 821 (2007/10/03)

The present research work has been undertaken in the synthesis of nitrogen, nitrogen and sulphur containing heteroacycles and heterocycles and to investigate their applications in medicinal, agricultural, industrial, pharmacological and biochemical facult

Synthesis and antimicrobial activity of 1,3,5-thiadiazines and their isomerism into 1,3,5-triazines

Deohate, Pradip P.,Berad

, p. 638 - 642 (2007/10/03)

A series of 2,6-diphenylimino-4-(substituted)-benzylidene amino-1,3,5-thiadiazines 4a-g have been obtained by the basification of their hydrochlorides 3a-g, which are prepared by interaction of N-phenyl isocyanodichloride and 1-(substituted)-benzylidene amidino-3-phenyl thiocarbamides 2a-g. The latter have been synthesized by the condensation of 1-amidino-3-phenyl thiocarbamide 1 and different aliphatic and aromatic aldehydes. Compounds 4a-g on acylation afford monoacetyl derivatives 5a-g, on reaction with sodium nitrite in acidic medium afforded mononitroso derivatives 6a-g, and on boiling with 5% aqueous ethanolic (1:1) sodium hydroxide solution isomerize into corresponding 1-phenyl-2-phenylimino-4-(substituted)-benzylidene amino-6-thio-1,3,5-triazines 7a-g. The title compounds have been assayed for their antimicrobial activity against gram-positive as well as gram-negative microorganisms.

Conversion of alkylamines to thiocarbamoylguanidines

Francis,Deepa,Sreekala,Rajasekharan

, p. 3463 - 3470 (2007/10/03)

N-Alkyl-, N,N-dialkyl- or N-unsubstituted-N'-(arylthiocarbamoyl)guanidines are prepared in very good yield from amines and 1-(N-arylthiocarbamoyl)amidino3,5 -dimethylpyrazoles.

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