164666-68-6

Basic information

• Product Name: 3-Amino-6-chloro-2-picoline
• Synonyms: TIMTEC-BB SBB010194;3-AMINO-2-CHLORO-4-PICOLINE;3-AMINO-2-CHLORO-4-METHYLPYRIDINE;3-AMINO-6-CHLORO-2-METHYLPYRIDINE;3-AMINO-6-CHLORO-2-PICOLINE;5-AMINO-2-CHLORO-6-PICOLINE;6-CHLORO-2-METHYL-PYRIDIN-3-YLAMINE;2-CHLORO-4-METHYLPYRIDIN-3-AMINE
• CAS NO: 164666-68-6
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• Product Categories: PYRIDINE;HALIDE;Pyridine series;Pyridines;Boronic Acid;Amino-pyridine series
• Mol File: 164666-68-6.mol

Chemical Properties

• Melting Point: 93-94℃
• Boiling Point: 232.49°C (rough estimate)
• Flash Point: 126.7 °C
• Appearance: Pale yellow/Solid
• Density: 1.2124 (rough estimate)
• Vapor Pressure: 0.00272mmHg at 25°C
• Refractive Index: 1.4877 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 1.79±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-6-chloro-2-picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-6-chloro-2-picoline(164666-68-6)
• EPA Substance Registry System: 3-Amino-6-chloro-2-picoline(164666-68-6)

Safety Data

• Hazard Codes: Xi,T,Xn
• Statements: 22-37/38-41-20/21/22
• Safety Statements: 26-39-36/37-24/25
• RIDADR: 2811
• HazardClass: IRRITANT, TOXIC
• Hazardous Substances Data: 164666-68-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-6-chloro-2-picoline is used as a reactant for the preparation of Pyrido[3,2-e][1,4]diazepine derivatives, which exhibit anti-HIV-1 activity. This application highlights its potential in contributing to the development of treatments for HIV-1 infections.
Used in Chemical Synthesis:
As a versatile chemical intermediate, 3-Amino-6-chloro-2-picoline can be utilized in the synthesis of a wide range of chemical compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for various chemical reactions, making it a valuable building block in organic chemistry.

InChI:InChI=1/C6H7ClN2/c1-4-5(8)2-3-6(7)9-4/h2-3H,8H2,1H3

Upstream product

• 22280-60-0 6-chloro-4-methyl-3-nitropyridine 
• 109-06-8 α-picoline 
• 1824-81-3 2-Amino-6-methylpyridine 
• 22280-62-2 6-methyl-5-nitro-2-pyridinamine 
• 137129-98-7 6-chloro-2-methylpyridine-3-carboxylic acid 

Downstream Products

• 164666-87-9 N-(6-Chlor-2-methyl-3-pyridyl)benzolsulfonamid 
• 132606-40-7 3-bromo-6-chloro-2-methyl-pyridine 
• 123280-64-8 3,6-dichloro-2-methylpyridine 
• 218770-02-6 6-chloro-2-methyl-pyridin-3-ol 
• 889944-74-5 6-chloro-2-methylpyridine-3-sulfonyl chloride 
• 884494-78-4 6-chloro-3-fluoro-2-methylpyridine 
• 2254506-82-4 5-chloro-2,7-dimethyl-2H-pyrazolo[4,3-b]pyridine 
• 1357945-27-7 5-chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine 
• 94220-45-8 5-chloro-1H-pyrazolo[4,3-b]pyridine 
• 1351813-70-1 7-bromo-5-chloro-1H-pyrazolo[4,3-b]pyridine 
• 910486-35-0 N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE 

Relevant articles and documents

OXADIAZOLE MODULATORS OF S1P METHODS OF MAKING AND USING

The invention is directed to Compounds of Formula (I): wherein each variable is defined herein, as well as methods of making and using the compounds as agonists of S1P1 and/or S1P5 for instance for treating graft versus host disease and autoimmune diseases.

THIADIAZOLE MODULATORS OF S1P AND METHODS OF MAKING AND USING

The invention is directed to compounds of the formula: wherein each of the variables are defined herein, as well as methods of making and using the compounds as agonists of S1P1 and/or S1P5 for instance treating an autoimmune disease.

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS GPR120 AGONISTS

The present invention relates to a compound represented by formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related di

6-chloro-3-fluoro-2-pyridine carboxylic acid synthesis

The invention discloses a 6-chlorine-3-fluorine-2-picolinic acid synthesis process. The main starting material is 6-chlorine-3-fluorine-2-methylpyridine.The 6-chlorine-3-fluorine-2-methylpyridine serves as the starting material, dilute sulphuric acid is a solvent, potassium dichromate is an oxidizing agent, sodium tungstate (Na2WO4 2H2O) and crown ether are a composite catalyst, after reaction is completed, a crude product is obtained through conventional post-processing, the crude product is heated to be dissolved in an alkaline aqueous solution, unreacted micro raw materials and other impurities are extracted through an organic solvent, a water layer is acidized through mineral acid, pure 6-chlorine-3-fluorine-2-picolinic acid is obtained after cooling and crystallization are carried out, the yield is high, and the quality of the product is good.

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice

Analogs of A-98593 (1) and its enantiomer ABT-594 (2) with diverse substituents on the pyridine ring were prepared and tested for affinity to nicotinic acetylcholine receptor binding sites in rat brain and for analgesic activity in the mouse hot plate assay. Numerous types of modifications were consistent with high affinity for [3H]cytisine binding sites. By contrast, only selected modifications resulted in retention of analgesic potency in the ame range as 1 and 2. Analogs of 2 with one or two methyl substituents at the 3-position of the azetidine ring also were prepared and found to be substantially less active in both assays.

Synthesis of dihalopicoline N-oxides and their 4-nitro derivatives

Three aminohalo-substituted α- and β-picolines, six dihalo-substituted α- and β-picolines, six dihalo-substituted α- and β-picoline N-oxides and six respective dihalo-4-nitropicoline N-oxides were synthesized in excellent yields. Some properties of the products were reported. 1997 Plenum Publishing Corporation.

Pyrido[3,2-e][1,4]diazepines - Synthesis and anti-HIV-1-activity tests

Starting from the commercially available 6-methyl-2-pyridylamine (1) the pyrido[3,2-e][1,4]diazepine 14a was synthesized in 12 steps with 7% total yield. 14a, the N-methyl derivative 14b, the thiolactam 15a, the amidine 16, and the 1,2,4-triazole 17 were tested for anti-HIV-1-activity. None of the compounds tested possesses antiviral activity comparable to that of zidovudine (3'-azido-3'-desoxythymidine = AZT).