16588-34-4Relevant articles and documents
Catalytic study of the copper-based magnetic nanocatalyst on the aerobic oxidation of alcohols in water
Dehkordi, S. Saeid Saei,Albadi, Jalal,Jafari, Abbas Ali,Samimi, Heshmat Allah
, p. 2527 - 2538 (2021/03/24)
A copper-based magnetic nanocatalyst has been prepared by co-precipitation method and characterized by FESEM, EDS, TEM, XRD, XRF, ICP–OES, FTIR, and BET analysis. This new nanocatalyst displays a good activity toward the aerobic oxidation of a wide range of alcohols in water. Moreover, it is recyclable up to five following runs by simple filtration without any significant loss of its catalytic activity.
Design and Synthesis of Ligand-Tag Exchangeable Photoaffinity Probe Utilizing Nosyl Chemistry
Saaidin, Aimi Suhaily,Murai, Yuta,Ishikawa, Takuya,Monde, Kenji
supporting information, p. 7563 - 7567 (2019/12/15)
Construction of a fluorophore or high-sensitive mass tag on target molecules would promise the facile analysis in photoaffinity labeling. A novel 2-nitrobenzenesulfonyl (nosyl; Ns) diazirine, which exhibits bifunctional properties for efficient photoaffinity labeling, was designed. This strategy highlights the simplicity of the chemical probe and its ability to install identification tags via Meisenheimer complex by SNAr after photo-labelling. Herein, in this study, we synthesized new Ns diazirine and demonstrated further studies in terms of photoactivation and SNAr reaction in aqueous condition.
Synthesis and evaluation of antinociceptive and anti-inflammatory effects of nitro-porphyrins
Zapata-Morales, Juan Ramón,Pérez-González, Cuauhtémoc,Alonso-Castro, Angel Josabad,Martell-Mendoza, Miguel,Hernández-Munive, Abigail,Pérez-Gutiérrez, Salud
, p. 1782 - 1791 (2018/05/28)
This manuscript reports the anti-inflammatory and antinociceptive effects of 4 nitrophenyl-porphyrins: 5,10,15,20-tetra-(3-nitrophenyl)-porphyrin (TNPP), 5,10,15,20-tetra-(4-fluoro-3-nitrophenyl)-porphyrin (TpFNPP), 5,10,15,20-tetra-(4-chloro-3-nitrophenyl)-porphyrin (TpClNPP), and 5,10,15,20-tetra-(4-bromo-3-nitrophenyl)-porphyrin (TpBrNPP). The in vivo anti-inflammatory assays were tested on the acute and chronic TPA (12-O-tetradecanoylphorbol 13-acetate) induced ear edema. The in vitro anti-inflammatory assay was carried out using J774A.1 murine macrophages stimulated with LPS. All nitro-porphyrins decreased inflammation significantly in the acute model: 58.55% (TNPP), 67.49% (TpBrNPP), 67.49% (TpClNPP), and 71.32% (TpFNPP). TpFNPP (50 μM/ml) increased the production of the anti-inflammatory cytokine IL-10, and decreased the production of the pro-inflammatory cytokines IL-1β, TNF-α, and IL-6 in macrophages activated with LPS, with similar activity than indomethacin (50 μM/ml). All porphyrins showed antinociceptive activity and lacked visible toxicity in the acute toxicity test. These results open the possibility of further studies to determine mechanisms of action, and study the influence of the structure on the activity of such compounds.