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1830-54-2

1830-54-2

Identification

  • Product Name:Dimethyl 1,3-acetonedicarboxylate

  • CAS Number: 1830-54-2

  • EINECS:217-385-8

  • Molecular Weight:174.153

  • Molecular Formula: C7H10O5

  • HS Code:29183000

  • Mol File:1830-54-2.mol

Synonyms:Dimethyl 3-oxoglutarate; Dimethyl 3-oxopentanedioate

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H317 May cause an allergic skin reaction

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:Dimethyl 1,3-Acetonedicarboxylate
  • Packaging:10g
  • Price:$ 403
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:Dimethyl 1,3-Acetonedicarboxylate
  • Packaging:250g
  • Price:$ 135
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Dimethyl 1,3-Acetonedicarboxylate >95.0%(GC)
  • Packaging:500g
  • Price:$ 276
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Dimethyl 1,3-Acetonedicarboxylate >95.0%(GC)
  • Packaging:100g
  • Price:$ 94
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Dimethyl 1,3-Acetonedicarboxylate >95.0%(GC)
  • Packaging:25g
  • Price:$ 32
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Dimethyl-3-oxoglutarate 95%
  • Packaging:10 g
  • Price:$ 16
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Dimethyl-3-oxoglutarate 95%
  • Packaging:25 g
  • Price:$ 26
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl 1,3-Acetonedicarboxylate 96%
  • Packaging:25g
  • Price:$ 37.8
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl 1,3-Acetonedicarboxylate 96%
  • Packaging:100g
  • Price:$ 82
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:Dimethyl 1,3-Acetonedicarboxylate
  • Packaging:10 g
  • Price:$ 610
  • Delivery:In stock
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Relevant articles and documentsAll total 10 Articles be found

Xylochemical synthesis and biological evaluation of shancigusin c and bletistrin g

Efferth, Thomas,Geske, Leander,Kauhl, Ulrich,Opatz, Till,Saeed, Mohamed E. M.,Schüffler, Anja,Thines, Eckhard

supporting information, (2021/06/16)

The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regiose-lective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.

Method for preparing silicon compounds

-

, (2019/11/14)

The invention provides a method for preparing silicon compounds, and belongs to the field of chemical synthesis. The method for preparing the silicon compounds comprises the following processes that citric acid is used as a raw material for performing oxidative decarboxylation to obtain a compound 1,3-acetone dicarboxylic acid; esterification reaction is carried out to obtain a compound 1,3-acetone dicarboxylic acid dimethyl ester; catalytic hydrogenation reduction is carried out to obtain a compound 3-hydroxyglutaric acid dimethyl ester; etherification reaction is carried out to obtain a compound3-tertiary butyl dimethyl siloxy dimethyl glutarate; saponification, dehydration and purification are carried out to obtain 3-tert-butyl-dimethylsiloxyglutaric anhydride; and a catalyst for catalytic hydrogenation is Cu/ZnO/Al2O3 prepared by a precipitation reduction method. According to the method for preparing the silicon compounds, the catalyst for catalytic hydrogenation is optimized, so that in the hydrogenation reduction reaction, the hydrogenation activity of a Cu catalyst is significantly improved, the selectivity is increased, and the generation of by-products is reduced; and theproduct yield and purity are significantly improved by recrystallization with a mixed solvent.

Catalytic hydrogenation of persubstituted p-nitrosophenols

Slashchinin,Tovbis,Root,Zadov,Sokolenko

experimental part, p. 517 - 519 (2010/08/19)

Catalytic hydrogenation of dialkyl 2-hydroxy-4,6-dimethyl-5-nitrosobenzene- 1,3-dicarboxylates over Pd/C gave the corresponding previously unknown dialkyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylates. The first-order rate constants for the hydrogenation process were found to be linearly related to steric constants of the alkyl groups.

PROCESS FOR THE PREPARATION OF DIALKYL 3-OXOGLUTARATES

-

Page 20-26, (2010/02/09)

This invention relates to a process for the preparation of 3-oxoglutarates of general formula (I), wherein R stands for methyl or ethyl. Said process comprises reacting citric acid of the formula (II) or the monohydrate thereof with chlorosulphonic acid in a lower chlorinated aliphatic hydrocarbon and reacting the intermediate thus obtained with methanol or ethanol by applying a ratio of lower chlorinated aliphatic hydrocarbon to chlorosulphonic acid in the range of 0,1:1 to 1:1 by volume and carrying out the addition of citric acid to the mixture of chlorosulphonic acid and lower aliphatic hydrocarbon at a rate of 1 - 2 kg/minute. The dialkyl 3-oxoglutarates are valuable pharmaceutical intermediates.

Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates

-

Page 2, (2008/06/13)

Process for the industrial synthesis of the compound of formula (I): Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.

Process route upstream and downstream products

Process route

methanol
67-56-1

methanol

3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

dimethyl 2-methoxypropene-1,3-dicarboxylate
100009-70-9

dimethyl 2-methoxypropene-1,3-dicarboxylate

trimethyl aconitate
20820-77-3

trimethyl aconitate

trimethyl citrate
1587-20-8

trimethyl citrate

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

Conditions
Conditions Yield
citric acid; With chlorosulfonic acid; In dichloromethane; at 10 - 15 ℃; for 5 - 6h;
methanol; In dichloromethane; at 3 - 35 ℃; for 2h; Conversion of starting material;
87.3%
methanol
67-56-1

methanol

acetonedicarboxylic acid
542-05-2

acetonedicarboxylic acid

3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

Conditions
Conditions Yield
With hydrogenchloride; sulfuric acid; sodium chloride; at 36 ℃; for 3.5h;
70.3%
With hydrogenchloride;
With sulfuric acid;
With fuming sulphuric acid; citric acid;
methyl 3-(dicyanomethylene)-5-hydroxy-5-methoxy-4-pentenoate morpholine salt

methyl 3-(dicyanomethylene)-5-hydroxy-5-methoxy-4-pentenoate morpholine salt

3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

Conditions
Conditions Yield
With sulfur; In methanol; for 2h; Heating / reflux; Industry scale;
Malonic acid monomethyl ester
16695-14-0

Malonic acid monomethyl ester

3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

Conditions
Conditions Yield
With hydrogenchloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethyl acetate;
94.3%
With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; Yield given;
methanol
67-56-1

methanol

3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

Conditions
Conditions Yield
citric acid; With chlorosulfonic acid; at 20 ℃; for 1h;
methanol; at 35 ℃; for 2h;
82%
With sulfuric acid; Yield given. Multistep reaction; 1.) 20-25 deg C, 3 h; 45 deg C, 6 h, 2.) 35-40 deg C, 1 h;
3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

Conditions
Conditions Yield
With sulfuric acid; sulfur trioxide; Behandeln des Reaktionsgemisches mit Methanol.;
Multi-step reaction with 2 steps
1: sulfuric acid / 7 h / -3 - 30 °C
2: hydrogenchloride; sulfuric acid; sodium chloride / 3.5 h / 36 °C
With hydrogenchloride; sulfuric acid; sodium chloride;
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

Conditions
Conditions Yield
With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -45 ℃; 1.) 30 min, 2.) 90 min;
3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

Conditions
Conditions Yield
With chromium(VI) oxide; sulfuric acid; toluene; at 65 ℃;
methanol
67-56-1

methanol

3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

Conditions
Conditions Yield
3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

Conditions
Conditions Yield

Global suppliers and manufacturers

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  • Simagchem Corporation
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  • Chemwill Asia Co., Ltd.
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  • Amadis Chemical Co., Ltd.
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  • LIDE PHARMACEUTICALS LIMITED
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  • Shaanxi BLOOM TECH Co.,Ltd
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  • Main Products:80
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