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Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies
Rashid, Umer,Rahim, Fazal,Taha, Muhammad,Arshad, Muhammad,Ullah, Hayat,Mahmood, Tariq,Ali, Muhammad
, p. 111 - 116 (2016)
Sixteen 4-hydroxycoumarin derivatives were synthesized, characterized through EI-MS and 1H NMR and screened for urease inhibitory potential. Three compounds exhibited better urease inhibition than the standard inhibitor thiourea (IC50 = 21 ± 0.11 μM) while other four compounds exhibited good to moderate inhibition with IC50 values between 29.45 ± 1.1 μM and 69.53 ± 0.9 μM. Structure activity relationship was established on the basis of molecular docking studies, which helped to predict the binding interactions of the most active compounds.
Functionalized 4-hydroxy coumarins: Novel synthesis, crystal structure and DFT calculations
Stefanou, Valentina,Matiadis, Dimitris,Melagraki, Georgia,Afantitis, Antreas,Athanasellis, Giorgos,Igglessi-Markopoulou, Olga,McKee, Vickie,Markopoulos, John
experimental part, p. 384 - 402 (2011/03/22)
A novel short-step methodology for the synthesis in good yields of functionalized coumarins has been developed starting from an activated precursor, the N-hydroxysuccinimide ester of O-acetylsalicylic acid. The procedure is based on a tandem C-acylation-c
Efficient synthesis of trisubstituted [1]benzopyrano[4,3-b]pyrrol-4(1H)-one derivatives from 4-hydroxycoumarin
Liao, Yuan-Xiu,Kuo, Pei-Yu,Yang, Ding-Yah
, p. 1599 - 1602 (2007/10/03)
Various trisubstituted [1]benzopyrano[4,3-b]pyrrol-4(1H)-one derivatives have been synthesized from 4-hydroxycoumarin with a 30-40% yield over six steps. The key step of the synthesis is a base-promoted intramolecular cyclization of enamines 5, followed by dehydration to generate the fused pyrrole ring.