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19492-11-6

19492-11-6

Identification

Synonyms:3-Benzoyl-2-hydroxy-chromen-4-one;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 8 Articles be found

Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies

Rashid, Umer,Rahim, Fazal,Taha, Muhammad,Arshad, Muhammad,Ullah, Hayat,Mahmood, Tariq,Ali, Muhammad

, p. 111 - 116 (2016)

Sixteen 4-hydroxycoumarin derivatives were synthesized, characterized through EI-MS and 1H NMR and screened for urease inhibitory potential. Three compounds exhibited better urease inhibition than the standard inhibitor thiourea (IC50 = 21 ± 0.11 μM) while other four compounds exhibited good to moderate inhibition with IC50 values between 29.45 ± 1.1 μM and 69.53 ± 0.9 μM. Structure activity relationship was established on the basis of molecular docking studies, which helped to predict the binding interactions of the most active compounds.

Functionalized 4-hydroxy coumarins: Novel synthesis, crystal structure and DFT calculations

Stefanou, Valentina,Matiadis, Dimitris,Melagraki, Georgia,Afantitis, Antreas,Athanasellis, Giorgos,Igglessi-Markopoulou, Olga,McKee, Vickie,Markopoulos, John

experimental part, p. 384 - 402 (2011/03/22)

A novel short-step methodology for the synthesis in good yields of functionalized coumarins has been developed starting from an activated precursor, the N-hydroxysuccinimide ester of O-acetylsalicylic acid. The procedure is based on a tandem C-acylation-c

Efficient synthesis of trisubstituted [1]benzopyrano[4,3-b]pyrrol-4(1H)-one derivatives from 4-hydroxycoumarin

Liao, Yuan-Xiu,Kuo, Pei-Yu,Yang, Ding-Yah

, p. 1599 - 1602 (2007/10/03)

Various trisubstituted [1]benzopyrano[4,3-b]pyrrol-4(1H)-one derivatives have been synthesized from 4-hydroxycoumarin with a 30-40% yield over six steps. The key step of the synthesis is a base-promoted intramolecular cyclization of enamines 5, followed by dehydration to generate the fused pyrrole ring.

Process route upstream and downstream products

Process route

4-hydroxy[1]benzopyran-2-one
1076-38-6,92395-12-5

4-hydroxy[1]benzopyran-2-one

benzoyl chloride
98-88-4

benzoyl chloride

3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
With pyridine; at 20 ℃; for 0.166667h;
85%
ethyl [(2-acetoxyphenyl)hydroxymethylidene]benzoylacetate

ethyl [(2-acetoxyphenyl)hydroxymethylidene]benzoylacetate

3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
With sodium ethanolate; In ethanol; at 20 ℃; for 24h;
61%
With ethanol; sodium; at 20 ℃; for 24h;
1.83 mg
3-phenyl-4H-furo<3,2-c><1>benzopyran-4-one
33184-20-2

3-phenyl-4H-furo<3,2-c><1>benzopyran-4-one

3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
With 5,15,10,20-tetraphenylporphyrin; In chloroform; at 20 ℃; for 3h; Inert atmosphere;
71%
3-Benzoyl-2-methylthio-chromon
84941-67-3

3-Benzoyl-2-methylthio-chromon

3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
With potassium hydroxide; In ethanol; for 1.5h; Heating;
87%
Multi-step reaction with 2 steps
1: 74 percent / ethanol / 2 h / Heating
2: conc. aq. HCl, acetic acid / H2O / 4 h / 100 °C
With hydrogenchloride; acetic acid; In ethanol; water;
2-oxo-2H-chromen-4-yl benzoate
16709-58-3

2-oxo-2H-chromen-4-yl benzoate

3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
With aluminium trichloride; at 130 - 140 ℃; for 1h;
65%
With potassium cyanide; triethylamine; In dichloromethane; at 20 ℃; for 48h;
2-oxo-2H-chromen-4-yl benzoate; With aluminum (III) chloride; at 140 ℃; for 1h;
With hydrogenchloride; In water; at 50 ℃;
2.2 g
3-Benzoyl-2-piperidino-chromon
84941-80-0

3-Benzoyl-2-piperidino-chromon

3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
With hydrogenchloride; acetic acid; In water; at 100 ℃; for 4h;
3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: DCC / tetrahydrofuran / 3 - 5 °C
2: 1.4 g / NaH / tetrahydrofuran / 2.5 h / 20 °C
3: 61 percent / EtONa / ethanol / 24 h / 20 °C
With sodium ethanolate; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol;
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 2 h / 0 - 20 °C / Inert atmosphere
3.1: ethanol; sodium / 24 h / 20 °C
With ethanol; sodium; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; mineral oil;
4-hydroxy[1]benzopyran-2-one
1076-38-6,92395-12-5

4-hydroxy[1]benzopyran-2-one

3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 76 percent / Et3N / toluene / 5 h / Heating
2: 65 percent / AlCl3 / 1 h / 130 - 140 °C
With aluminium trichloride; triethylamine; In toluene;
Multi-step reaction with 3 steps
1: potassium carbonate / acetone / Reflux
2: polyphosphoric acid (PPA)
3: 5,15,10,20-tetraphenylporphyrin / chloroform / 3 h / 20 °C / Inert atmosphere
With 5,15,10,20-tetraphenylporphyrin; potassium carbonate; In chloroform; acetone;
1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione
1469-94-9

1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione

3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 1.) KOH / 1.) DMSO, water, ice-cooling, 4 h, 2.) room temp., 2 h
2: 74 percent / ethanol / 2 h / Heating
3: conc. aq. HCl, acetic acid / H2O / 4 h / 100 °C
With hydrogenchloride; potassium hydroxide; acetic acid; In ethanol; water;
Multi-step reaction with 2 steps
1: 1.) KOH / 1.) DMSO, water, ice-cooling, 4 h, 2.) room temp., 2 h
2: 87 percent / KOH / aq. ethanol / 1.5 h / Heating
With potassium hydroxide; In ethanol;
acetylsalicylic acid N-hydroxysuccinimide ester
84388-73-8

acetylsalicylic acid N-hydroxysuccinimide ester

3-benzoyl-4-hydroxy-2H-chromen-2-one
19492-11-6

3-benzoyl-4-hydroxy-2H-chromen-2-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
1.2: 2 h / 0 - 20 °C / Inert atmosphere
2.1: ethanol; sodium / 24 h / 20 °C
With ethanol; sodium; sodium hydride; In tetrahydrofuran; mineral oil;

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  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
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