197846-82-5

Basic information

• Product Name: 4-(3-BROMOPHENYL)MORPHOLINE
• Synonyms: 1-Bromo-3-(morpholin-4-yl)benzene;4-(3-Bromophenyl)morpholine 96%;N-(3-BroMophenyl)Morpholine;Morpholine,4-(3-broMophenyl)-;4-(3-Bromophenyl)morpholine96%;1-BROMO-3-(4-MORPHOLINO)BENZENE;4-(3-BROMOPHENYL)MORPHOLINE
• CAS NO: 197846-82-5
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.11
• Product Categories: Aryl;Organohalides;Halides;Phenyls & Phenyl-Het;pharmacetical
• Mol File: 197846-82-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 341.06 °C at 760 mmHg
• Flash Point: 160.067 °C
• Appearance: /
• Density: 1.433
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.02±0.40(Predicted)
• CAS DataBase Reference: 4-(3-BROMOPHENYL)MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-BROMOPHENYL)MORPHOLINE(197846-82-5)
• EPA Substance Registry System: 4-(3-BROMOPHENYL)MORPHOLINE(197846-82-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 197846-82-5(Hazardous Substances Data)

Usage

General Description

4-(3-Bromophenyl)morpholine is a chemical compound with the molecular formula C10H12BrNO. It is a white to off-white solid that is used in the synthesis of pharmaceuticals and other organic compounds. 4-(3-BROMOPHENYL)MORPHOLINE is a morpholine derivative with a bromine atom attached to the phenyl group, making it a halogenated compound. It has the potential to be used as an intermediate in the production of various drugs and agrochemicals. In addition to its role in organic synthesis, 4-(3-Bromophenyl)morpholine may also have uses as a research tool in the study of chemical reactions and the development of new materials.

Upstream product

• 110-91-8 morpholine 
• 108-86-1 bromobenzene 
• 108-36-1 1,3-dibromobenzene 
• 591-19-5 m-Bromoaniline 
• 540-51-2 2-bromoethanol 
• 736990-80-0 4-bromo-2-morpholinobenzaldehyde 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Downstream Products

• 294852-03-2 1-Amino-4-[3-(morpholin-4-yl)phenyl]naphthalene 
• 852227-95-3 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine 
• 1350730-00-5 3-[5-(3-morpholin-4-ylphenoxy)pyrimidin-2-ylamino]-benzonitrile 
• 1350730-01-6 2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile 
• 1350730-02-7 2-fluoro-5-{methyl-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-yl-]amino}benzonitrile 
• 1350730-03-8 2,6-difluoro-3-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile 
• 1350730-04-9 2-chloro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile 
• 1350730-05-0 3-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile 
• 1350730-06-1 2-fluoro-3-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile 
• 1350730-07-2 4-fluoro-3-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile 
• 1350730-08-3 2-methoxy-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile 
• 1350660-03-5 4-[3-(2-chloro-pyrimidin-5-yloxy)phenyl]morpholine 
• 863377-22-4 [3-(morpholine-4-yl)phenyl]boronic acid 
• 1139717-68-2 4-[3-(6-chloropyridin-3-yloxy)phenyl]morpholine 

Relevant articles and documents

Transition Metal-Free Synthesis of meta-Bromo- and meta-Trifluoromethylanilines from Cyclopentanones by a Cascade Reaction

Anilines are key constituents in biologically active compounds and often obtained from transition metal-catalyzed coupling of an aryl halide with an amine. In this work, we report a transition metal-free method for the synthesis of meta-bromo- and meta-trifluoromethylanilines starting from 3-tribromomethylcyclopentanone or 3-(2-bromo-2-chloro-1,1,1-trifluoroethyl)cyclopentanone, respectively. The scope of the transformation is shown by application of primary, secondary and aromatic amines. The reaction proceeds in acceptable to high yields (20–81 %), and allows for the synthesis of anilines with substitution patterns otherwise difficult to access.

Catalyst-free photodecarbonylation ofortho-amino benzaldehyde

It is almost a consensus that decarbonylation of the aldehyde group (-CHO) needs to not only be mediated by transition metal catalysts, but also requires severe reaction conditions (high temperature and long reaction time). In this work, inspired by the “conformational-selectivity-based” design strategy, we broke this consensus and discovered a catalyst-free photodecarbonylation of the aldehyde group. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into theortho-position of the aldehyde group. A diverse array of tertiary amines is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations of the mechanism and the experiments on well-designed special substrates revealed that our photodecarbonylation depends on the conformational specificity of the aldehyde group and tertiary amine, and occurs through an unusual [1,4]-H shift and a subsequent [1,3]-H shift.

Bicyclic alkaloid compound, preparation method and applications thereof

The present invention relates to a bicyclic alkaloid compound, or a tautomer, a stereoisomer, a racemate, the non-equal mixture of enantiomers, a geometric isomer, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, and a pharmaceutical composition containing the compound. The invention further discloses uses of the compounds and the pharmaceutical composition thereof as drugs, especially as anti-inflammatory drugs and anti-fibrotic drugs.