20264-95-3

Basic information

• Product Name: 1-CHLORO-2-(4-NITROPHENYL)ETHANE
• Synonyms: 1-CHLORO-2-(4-NITROPHENYL)ETHANE;4-(2-Chloroethyl)nitrobenzene;NSC 143402 1-(2-Chloroethyl)-4-nitrobenzene
• CAS NO: 20264-95-3
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 20264-95-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 171℃
• Boiling Point: 307.5°C at 760 mmHg
• Flash Point: 139.8°C
• Appearance: /
• Density: 1.275g/cm³
• Vapor Pressure: 0.00131mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 1-CHLORO-2-(4-NITROPHENYL)ETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-2-(4-NITROPHENYL)ETHANE(20264-95-3)
• EPA Substance Registry System: 1-CHLORO-2-(4-NITROPHENYL)ETHANE(20264-95-3)

Safety Data

• Hazardous Substances Data: 20264-95-3(Hazardous Substances Data)

Usage

Description

1-CHLORO-2-(4-NITROPHENYL)ETHANE is a chemical compound characterized by the molecular formula C8H7ClNO2. It is a chlorinated ether that features a nitrophenyl group, which is integral to its reactivity and applications in various chemical processes. 1-CHLORO-2-(4-NITROPHENYL)ETHANE is recognized for its versatility in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and fine chemicals. Its chemical properties allow it to participate in reactions such as nucleophilic substitution and aromatic nitration, making it a valuable intermediate in the synthesis of a range of compounds.

Uses

Used in Pharmaceutical Synthesis:
1-CHLORO-2-(4-NITROPHENYL)ETHANE is used as an intermediate in the synthesis of pharmaceuticals for its ability to undergo key chemical reactions that facilitate the creation of diverse medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, 1-CHLORO-2-(4-NITROPHENYL)ETHANE is utilized as a precursor in the development of various agrochemicals, contributing to its role in crop protection and enhancement of agricultural yields.
Used in Organic Synthesis Research:
1-CHLORO-2-(4-NITROPHENYL)ETHANE is employed as a research compound in organic synthesis, where its reactivity with nucleophiles and its susceptibility to aromatic nitration are exploited to explore new synthetic pathways and develop innovative chemical methodologies.
Used as an Insect Repellent:
1-CHLORO-2-(4-NITROPHENYL)ETHANE is used as an insect repellent due to its potential to deter insects, providing a chemical solution for pest control in various settings.
Used as an Antifungal Agent:
1-CHLORO-2-(4-NITROPHENYL)ETHANE is also recognized for its antifungal properties, making it a candidate for use in antifungal applications to prevent the growth of fungi in different environments.
Safety Precautions:
Given its toxic nature and potential to cause irritation to the skin, eyes, and respiratory system, 1-CHLORO-2-(4-NITROPHENYL)ETHANE should be handled with care. It is crucial to work in a well-ventilated area and to use appropriate personal protective equipment to minimize health risks during its use in laboratories and industrial settings.

InChI:InChI=1/C8H8ClNO2/c9-6-5-7-1-3-8(4-2-7)10(11)12/h1-4H,5-6H2

Upstream product

• 622-24-2 2-phenylethyl chloride 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 98-07-7 Benzotrichlorid 
• 59457-26-0 1-chloro-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one 
• 60-12-8 2-phenylethanol 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 74-85-1 ethene 
• 100-05-0 4-nitrobenzenediazonium chloride 
• 64-04-0 phenethylamine 

Downstream Products

• 14310-29-3 1-nitro-4-phenethylbenzene 
• 80259-15-0 2-(4-nitro-phenyl)ethanesulfonyl chloride 
• 108838-76-2 N-(4-nitro-phenethyl)-m-anisidine 
• 19904-92-8 4-methoxy-N-(4-nitrophenethyl)aniline 
• 1665-60-7 diethyl-(4-amino-phenethyl)-amine 
• 841-19-0 N-phenyl-4-nitrophenethylamine 
• 93758-69-1 3-(4-nitro-phenethylamino)-phenol 
• 37135-87-8 N-methyl-N-(4-nitro-phenethyl)-aniline 
• 108843-63-6 acetic acid-[3-(4-nitro-phenethylamino)-anilide] 
• 156159-81-8 5'-O-(2-dansylethoxycarbonyl)-2'-deoxy-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite> 
• 156159-82-9 5'-O-(2-dansylethoxycarbonyl)-thymidine 3'-<2-(4-nitrophenyl)ethyl N,N-diethylphosphoramidite> 
• 156159-78-3 5'-O-(2-dansylethoxycarbonyl)-thymidine 3'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite> 
• 156159-83-0 5'-O-(2-dansylethoxycarbonyl)-2'-deoxy-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl N,N-diethylphosphoramidite> 
• 156046-19-4 3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite> 

Relevant articles and documents

Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling

A catalytic system for the chlorination of alcohols under Appel conditions was developed. Benzotrichloride is used as a cheap and readily available chlorinating agent in combination with trioctylphosphane as the catalyst and phenylsilane as the terminal reductant. The reaction has several advantages over other variants of the Appel reaction, e.g., no additional solvent is required and the phosphane reagent is used only in catalytic amounts. In total, 27 different primary, secondary, and tertiary alkyl chlorides were synthesized in yields up to 95%. Under optimized conditions, it was also possible to convert epoxides and an oxetane to the dichlorinated products.

HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA

This invention relates to compounds of the formula 1 wherein X, Y, Z, A, R', R2, R3, R4, R9, W' and W2 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other diso

Nucleotides. Part XL. Synthesis and characterization of modified 2'-5' adenylate trimers - Potential antiviral agents

2'-5' Adenylate trimers 41-44 carrying the (tert-butyl)dimethylsilyl (tbds) group at the 3'-OH position of various sugar moieties were synthesized via the phosphoramidite method. The use of the (tert-butyloxy)carbony (boc) and (2-(4-nitrophenyl)ethylsulfo