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2578-57-6

2578-57-6

Identification

  • Product Name:Glycine, L-prolyl-

  • CAS Number: 2578-57-6

  • EINECS:

  • Molecular Weight:172.184

  • Molecular Formula: C7H12N2O3

  • HS Code:2933990090

  • Mol File:2578-57-6.mol

Synonyms:Glycine,N-L-prolyl- (7CI,8CI);45: PN: WO03052099 PAGE: 84 claimed protein;L-Prolylglycine;NSC 89175;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:TRC
  • Product Description:H-Pro-Gly-OH
  • Packaging:500mg
  • Price:$ 90
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Pro-Gly
  • Packaging:1g
  • Price:$ 278
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:H-Pro-Gly-OH 95+%
  • Packaging:1g
  • Price:$ 80
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:H-Pro-Gly-OH 95+%
  • Packaging:5g
  • Price:$ 180
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:H-Pro-Gly-OH 95+%
  • Packaging:10g
  • Price:$ 340
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  • Manufacture/Brand:ChemScene
  • Product Description:L-Prolylglycine 99.01%
  • Packaging:10g
  • Price:$ 430
  • Delivery:In stock
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  • Manufacture/Brand:ChemScene
  • Product Description:L-Prolylglycine 99.01%
  • Packaging:5g
  • Price:$ 246
  • Delivery:In stock
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  • Manufacture/Brand:ChemScene
  • Product Description:L-Prolylglycine 99.01%
  • Packaging:1g
  • Price:$ 98
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  • Manufacture/Brand:Chem-Impex
  • Product Description:Pro-Gly-OH,95%(HPLC) 95%(HPLC)
  • Packaging:10G
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  • Manufacture/Brand:Chem-Impex
  • Product Description:Pro-Gly-OH,95%(HPLC) 95%(HPLC)
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Relevant articles and documentsAll total 12 Articles be found

Leonurine derivative and application thereof in preparing medicine for preventing or treating ischemic cerebrovascular diseases

-

Paragraph 0119-0121, (2021/03/30)

The invention provides a leonurine derivative and application of the leonurine derivative in preparation of a medicine for preventing or treating ischemic cerebrovascular diseases. The leonurine derivative has a structure as shown in a general formula (I), wherein X is selected from O or NH; Y is selected from any one of natural amino acid, substituted amino acid or amino alcohol; Z is selected from H, proline and any substituted proline. Pharmacological experiments prove that the leonurine derivative provided by the invention has the effects of neuroprotection, cerebral infarction area reduction and animal neurobehavioral scoring, and is good in safety, so that the leonurine derivative has important significance for developing novel medicines for preventing or treating ischemic cerebrovascular diseases.

Design, synthesis, and biological evaluation of novel stachydrine derivatives as potent neuroprotective agents for cerebral ischemic stroke

Zhang, Liang,Li, Feng,Hou, Chenhui,Zhu, Sifeng,Zhong, Lili,Zhao, Jianchun,Song, Cai,Li, Wenbao

, p. 2529 - 2542 (2020/05/25)

Stachydrine is a natural product with multiple protective biological activities, including those involved in preventing cancer, ischemia, and cardiovascular disease. However, its use has been limited by low bioavailability and unsatisfactory efficacy. To address this problem, a series of stachydrine derivatives (A1/A2/A3/A4/B1/B2/B3/B4) were designed and synthesized, and biological studies were carried out in vitro and in vivo. When compared with stachydrine, Compound B1 exhibited better neuroprotective effects in vitro, and significantly reduced infarction size in the model of the middle cerebral artery occlusion rat model. Therefore, Compound B1 was selected for further research on ischemic stroke. [Figure not available: see fulltext.].

Aggregation propensity of amyloidogenic and elastomeric dipeptides constituents

Kumar, Vikas,Krishna, K. Vijaya,Khanna, Shruti,Joshi, Khashti Ballabh

supporting information, p. 5369 - 5376 (2016/08/05)

This study demonstrates the self-assembly of N- and C-terminal protected dipeptides Phe–Gly and Pro–Gly which were derived from amyloidogenic and elastomeric peptide sequences. These constituents afforded nanostructured supramolecular ensembles through va

Coupling-Reagent-Free Synthesis of Dipeptides and Tripeptides Using Amino Acid Ionic Liquids

Furukawa, Shinya,Fukuyama, Takahide,Matsui, Akihiro,Kuratsu, Mai,Nakaya, Ryotaro,Ineyama, Takashi,Ueda, Hiroshi,Ryu, Ilhyong

supporting information, p. 11980 - 11983 (2015/08/18)

A general method for the synthesis of dipeptides has been developed, which does not require any coupling reagents. This method is based on the reaction of readily available HCl salts of amino acid methyl esters with tetrabutylphosphonium amino acid ionic liquids. The isolation procedure of stepwise treatment with AcOH is easy to carry out. The method was extended to the synthesis of tripeptide, tyrosyl-glycyl-glycine, present in IMREG-1, also.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

-

, (2010/03/02)

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

Process route upstream and downstream products

Process route

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 71 percent / N,N'-diciclohexylcarbodiimide / 1,2-dimethoxy-ethane / 20 h / 4 °C
2: 39 percent / triethylamine / dimethylformamide / 48 h / Ambient temperature
3: AcOH-H2O, 2-propanol, H2 / Pd/C
With hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; isopropyl alcohol; palladium on activated charcoal; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
Multi-step reaction with 2 steps
1: 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine
2: AcOH-H2O, 2-propanol, H2 / Pd/C
With hydrogen; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; isopropyl alcohol; palladium on activated charcoal;
N-trityl-proline succinimide ester
92466-15-4

N-trityl-proline succinimide ester

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 39 percent / triethylamine / dimethylformamide / 48 h / Ambient temperature
2: AcOH-H2O, 2-propanol, H2 / Pd/C
With hydrogen; acetic acid; triethylamine; isopropyl alcohol; palladium on activated charcoal; In N,N-dimethyl-formamide;
Trt-Pro-Gly-OBzl
92466-05-2

Trt-Pro-Gly-OBzl

Conditions
Conditions Yield
With hydrogen; acetic acid; isopropyl alcohol; palladium on activated charcoal; Yield given. Multistep reaction;
N-tert-butyloxycarbonyl-L-prolylglycine
51785-82-1,250290-80-3

N-tert-butyloxycarbonyl-L-prolylglycine

N-prolylglycine
2578-57-6

N-prolylglycine

Conditions
Conditions Yield
With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
98%
N-tert-butyloxycarbonyl-L-prolylglycine; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
345 mg
With trifluoroacetic acid; In dichloromethane; at 0 ℃;
N-carbobenzoxyprolylglycine
2766-18-9

N-carbobenzoxyprolylglycine

N-prolylglycine
2578-57-6

N-prolylglycine

Conditions
Conditions Yield
With hydrogen; 10% palladium on active carbon; In methanol; water;
95%
With ethanol; palladium; acetic acid; Hydrogenation;
With ethanol; palladium; acetic acid; Hydrogenation.Reagens 4: Platin;
With methanol; palladium; acetic acid; Hydrogenation;
With palladium 10% on activated carbon; hydrogen; In methanol; for 3h;
N-prolylglycine
2578-57-6

N-prolylglycine

Conditions
Conditions Yield
With dimethyl ether-poly(hydrogen fluoride); at 0 ℃; for 1h;
93%
Z-L-Pro-Gly-OBzl
7536-45-0

Z-L-Pro-Gly-OBzl

N-prolylglycine
2578-57-6

N-prolylglycine

Conditions
Conditions Yield
With hydrogen; acetic acid; palladium;
87%
N-Benzyloxycarbonyl-L-proline
1148-11-4

N-Benzyloxycarbonyl-L-proline

N-prolylglycine
2578-57-6

N-prolylglycine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 80 percent / ethyl acetate; dimethylformamide / 2 h / -10 - 20 °C
2: 76 percent / NaOH; HCl / acetone / 2 h
3: 95 percent / H2 / 10 percent Pd/C / H2O; methanol
With hydrogenchloride; sodium hydroxide; hydrogen; 10% palladium on active carbon; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone; 1: Addition / 2: Hydrogenation / 3: dealkylation;
Multi-step reaction with 2 steps
1: 1) NMM, ECF / 1) THF, -5 deg C, 10 min, 2) CHCl3, 0 deg C, 1 h; r.t., overnight
2: 87 percent / acetic acid, H2 / Pd black
With 4-methyl-morpholine; hydrogen; chloroformic acid ethyl ester; acetic acid; palladium;
Multi-step reaction with 3 steps
1: pyridine; PCl3
2: aqueous NaOH; dioxane
3: palladium; acetic acid; aqueous methanol / Hydrogenation
With 1,4-dioxane; pyridine; methanol; sodium hydroxide; palladium; acetic acid; phosphorus trichloride;
Multi-step reaction with 3 steps
1: diethyl ether; PCl3
2: diethyl ether; aqueous NaOH
3: palladium; acetic acid; aqueous ethanol / Hydrogenation
With sodium hydroxide; diethyl ether; ethanol; palladium; acetic acid; phosphorus trichloride;
ethyl (N-benzoxycarbonyl-L-prolyl)glycinate
2766-31-6

ethyl (N-benzoxycarbonyl-L-prolyl)glycinate

N-prolylglycine
2578-57-6

N-prolylglycine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 76 percent / NaOH; HCl / acetone / 2 h
2: 95 percent / H2 / 10 percent Pd/C / H2O; methanol
With hydrogenchloride; sodium hydroxide; hydrogen; 10% palladium on active carbon; In methanol; water; acetone; 1: Hydrogenation / 2: dealkylation;
Multi-step reaction with 2 steps
1: aqueous NaOH; dioxane
2: palladium; acetic acid; aqueous methanol / Hydrogenation
With 1,4-dioxane; methanol; sodium hydroxide; palladium; acetic acid;
Multi-step reaction with 2 steps
1: aqueous NaOH; acetone
2: palladium; acetic acid; aqueous methanol / Hydrogenation
With methanol; sodium hydroxide; palladium; acetic acid; acetone;
Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: aqueous NaOH
2: pyridine; PCl3
3: aqueous NaOH; dioxane
4: palladium; acetic acid; aqueous methanol / Hydrogenation
With 1,4-dioxane; pyridine; methanol; sodium hydroxide; palladium; acetic acid; phosphorus trichloride;
Multi-step reaction with 3 steps
3: ethanol; aqueous NaOH
With sodium hydroxide; ethanol;
Multi-step reaction with 4 steps
1.1: triethylamine / methanol / 20 - 65 °C
2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 1 h / 0 °C / Inert atmosphere
2.2: 12 h / 20 °C / Inert atmosphere
3.1: sodium hydroxide / methanol / 6 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere
4.2: strong anion exchange resin
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane;
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 3 h / 0 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 25 °C
3: sodium hydrogencarbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / water; 1,4-dioxane / 12 h / 25 °C
4: trifluoroacetic acid / dichloromethane / 0 °C
With sodium hydrogencarbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;

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