26272-90-2Relevant articles and documents
Anti-HIV-Active Nucleoside Triphosphate Prodrugs
Jia, Xiao,Schols, Dominique,Meier, Chris
, p. 6003 - 6027 (2020)
We disclose a study on nucleoside triphosphate (NTP) analogues in which the γ-phosphate is covalently modified by two different biodegradable masking units and d4T as nucleoside analogue that enable the delivery of d4TTP with high selectivity in phosphate buffer (pH 7.3) and by enzyme-triggered reactions in human CD4+ T-lymphocyte CEM cell extracts. This allows the bypass of all steps normally needed in the intracellular phosphorylation. These TriPPPro-nucleotides comprising an acyloxybenzyl (AB; ester) or an alkoxycarbonyloxybenzyl (ACB; carbonate) in combination with an ACB moiety are described as NTP delivery systems. The introduction of these two different groups led to the selective formation of γ-(ACB)-d4TTPs by chemical hydrolysis and in particular by cell extract enzymes. γ-(AB)-d4TTPs are faster cleaved than γ-(ACB)-d4TTPs. In antiviral assays, the compounds are highly active against HIV-1 and HIV-2 in wild-type CEM/O cells and more importantly in thymidine kinase-deficient CD4+ T-cells (CEM/TK-).
Synthesis method of photosensitive material stabilizing agent of 4-hexadecyloxy carbonyloxy-3,5-dichlorobenzene ethyl formate
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Paragraph 0021; 0022; 0024, (2017/07/21)
The invention relates to a novel synthesis method of a photosensitive material stabilizing agent of 4-hexadecyloxy carbonyloxy-3,5-dichlorobenzene ethyl formate. 4-hydroxyl-3,5-dichlorobenzene ethyl formate is used as raw materials to take a reaction with hexadecyloxy carbonyl acyl chloride under the effect of acid-binding agents to obtain the 4-hexadecyloxy carbonyloxy-3,5-dichlorobenzene ethyl formate. The invention relates to a synthesis method of intermediates of 4-hydroxy-3,5-dichlorobenzene ethyl formate and the hexadecyloxy carbonyl acyl chloride, and the optimum reaction condition of the synthesis of the 4-hexadecyloxy carbonyloxy-3,5-dichlorobenzene ethyl formate, and provides a novel economical and practical method realizing simple operation.
Pyrene-derived novel one- and two-component organogelators
Babu,Sangeetha,Vijaykumar,Maitra, Uday,Rissanen, Kari,Raju
, p. 1922 - 1932 (2007/10/03)
A new class of alkyl-chainappended pyrene derivatives 4 - 14 were synthesized and evaluated for their gelation abilities. Depending on the nature of the linking group, these compounds gelated a number of organic solvents, either in the presence or in the absence of the acceptor molecule 2,4,7-trinitrofluorenone (TNF). Compounds with ester, ether, or alkyl linkages gelated a number of hydroxylic and hydrocarbon solvents by means of a charge-transfer interaction with TNF, while compounds with amide, urethane and urea linkers formed gels on their own in a variety of solvents by means of π-π stacking and hydrogen-bonding interactions. The X-ray crystal structure of urethane (S)-12 showed hydrogen-bonding and stacking features, as suggested by the model. The gels obtained were investigated by spectroscopic and electron microscopic techniques which provided structural insights.