27258-32-8

Basic information

• Product Name: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE
• Synonyms: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE;1H-PYRAZOLE-3-CARBOXALDEHYDE, 1-METHYL-;AKOS B007390;3-Formyl-1-methyl-1H-pyrazole;1-Methyl-1H-pyrazol-3-carbaldehyde;1-methyl-1H-Pyrazole-3-carboxaldehyde;1-Methyl-3-pyrazolecarboxaldehyde;1-Methylpyrazole-3-carbaldehyde
• CAS NO: 27258-32-8
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• Product Categories: Building Blocks;Pyrazole
• Mol File: 27258-32-8.mol

Chemical Properties

• Boiling Point: 218.9±13.0℃ (760 Torr)
• Flash Point: 86.2±19.8℃
• Appearance: /
• Density: 1.14±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.123mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.06±0.10(Predicted)
• CAS DataBase Reference: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE(27258-32-8)
• EPA Substance Registry System: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE(27258-32-8)

Safety Data

• Hazardous Substances Data: 27258-32-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-1H-pyrazole-3-carbaldehyde is used as a chemical intermediate for the synthesis of pharmaceutical drugs. Its unique structure allows for the creation of various drug molecules, contributing to the development of new medications.
Used in Chemical Research:
1-Methyl-1H-pyrazole-3-carbaldehyde is used as a research compound in the field of chemistry. Its properties and reactivity make it a valuable tool for studying chemical reactions and exploring new chemical pathways.
Used in Dye Industry:
1-Methyl-1H-pyrazole-3-carbaldehyde is used as an intermediate in the synthesis of dyes. Its chemical structure plays a role in the development of new dye products, enhancing the color palette available in various industries.

InChI:InChI=1/C5H6N2O/c1-7-3-2-5(4-8)6-7/h2-4H,1H3

Upstream product

• 84547-60-4 1-methyl-1H-pyrazole-3-carbonyl chloride 
• 84547-62-6 (1-methyl-1H-pyrazol-3-yl)methanol 
• 67751-23-9 4-(dimethylamino)-1,1-dimethoxy-but-3-en-2-one 
• 60-34-4 methylhydrazine 
• 3920-50-1 3-formylpyrazole 
• 74-88-4 methyl iodide 
• 25016-20-0 1-methylpyrazole-3-carboxylic acid 

Downstream Products

• 1214997-78-0 4-iodo-1-methyl-1H-pyrazole-3-carbaldehyde 
• 1309584-49-3 (E)-3-(3-(dihydroxyamino)phenyl)-2-(2-(1-methyl-1H-pyrazol-3-yl)vinyl)quinazolin-4(3H)-one 
• 1355994-27-2 ethyl 1-(4-methoxybenzyl)-3-((1-methyl-1H-pyrazol-3-yl)methylamino)-1H-pyrazole-4-carboxylate 
• 1610371-11-3 N-(4-bromophenyl)-1-methyl-1H-pyrazole-3-carbohydrazonoyl bromide 
• 1610371-12-4 methyl 1-(4-bromophenyl)-1',4-dimethyl-4,5-dihydro-1H,1'H-[3,3'-bipyrazole]-5-carboxylate 
• 1610371-13-5 1-((4-bromophenyl)-1',4-dimethyl-4,5-dihydro-1H,1'H-[3,3'-bipyrazol]-5-yl)methanol 
• 1610371-14-6 1-((4-bromophenyl)-1',4-dimethyl-4,5-dihydro-1H,1'H-[3,3'-bipyrazol]-5-yl)methyl methanesulfonate 
• 1610371-15-7 2-(1-(4-bromophenyl)-1',4-dimethyl-4,5-dihydro-1H,1'H-[3,3'-bipyrazol]-5-yl)acetonitrile 
• 1610371-16-8 2-(1',4-dimethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4,5-dihydro-1H,1'H-[3,3'-bipyrazol]-5-yl)acetonitrile 
• 1610371-83-9 C₃₁H₃₀FN₅O 
• 1610371-10-2 3-((2-(4-bromophenyl)hydrazono)methyl)-1-methyl-1H-pyrazole 
• 84547-62-6 (1-methyl-1H-pyrazol-3-yl)methanol 
• 79080-39-0 1-Methylpyrazole-3-carboxylic acid nitrile 
• 60031-47-2 1-(1-methyl-1H-pyrazol-3-yl)ethanol 

Relevant articles and documents

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Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides

The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which R1 is optionally substituted phenyl or C3-C7-cycloalkyl, R1a is hydrogen or fluorine, or R1a together with R1 is optionally substituted C3-C5-alkanediyl or C5-C7-cycloalkanediyl, R2 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C1-C4-alkoxy-C1-C2-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprises A) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and R2 has one of the meanings given above and B) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R1, R1a and n have one of the meanings given above; in the presence of a palladium catalyst; to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.

First copper-catalyzed intramolecular amidation in substituted 4-iodopyrazoles leading to the synthesis of pyrazolo [4,3-b] pyridin-5-onesn

An unprecedented copper-catalyzed intramolecular amidation of substituted 4-iodopyrazoles generated either via Baylis-Hillman or Horner-Wadsworth-Emmons chemistry for the synthesis of pyrazolo[4,3-b]pyridine-5-ones is described. In addition, the effect of

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4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.