34688-34-1

Basic information

• Product Name: glycerolcholine phosphate
• Synonyms: glycerolcholine phosphate
• CAS NO: 34688-34-1
• Molecular Weight: 257.224
• Mol File: 34688-34-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: glycerolcholine phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: glycerolcholine phosphate(34688-34-1)
• EPA Substance Registry System: glycerolcholine phosphate(34688-34-1)

Safety Data

• Hazardous Substances Data: 34688-34-1(Hazardous Substances Data)

Upstream product

• 59414-92-5 2-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)-2-oxo-1,3,2-dioxaphospholane 
• 75-50-3 trimethylamine 
• 55357-38-5 choline tosylate 
• 556-52-5 oxiranyl-methanol 
• 57090-45-6 (2R)-3-chloro-1,2-propanediol 
• 4826-71-5 phosphorylcholine chloride, calcium salt 
• 107-73-3 phosphorylcholine chloride 
• 96-24-2 3-monochloro-1,2-propanediol 
• 63-89-8 L-α-Dipalmitoylphosphatidylcholine 
• 34688-39-6 Phosphoric acid 2-chloro-ethyl ester 2-chloromethyl-4-nitro-phenyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 
• 59414-94-7 choline-2,2-dimethyl-1,3-dioxolane-4-methyl phosphate 

Downstream Products

• 18194-24-6 dimyristoylphosphatidylcholine 
• 13699-45-1 1-myristoyl-2-lyso-sn-glycero-3-phosphatidylcholine 
• 4016-41-5 1-octadec-9'-enoyl-2-hydroxy-sn-glycero-3-phosphocholine 
• 17364-18-0 1-palmitoyllysophosphatidylcholine 
• 2644-64-6 1,2-dipalmitoyl-rac-glycero-3-phosphatidylcholine 
• 6931-84-6 1-palmitoyl-2-lineleoylphosphatidylcholine 
• 39735-07-4 β-arachidonoyl-γ-palmitoyl-α-phosphatidylcholine 
• 17364-19-1 1-stearoyl-sn-glycero-3-phosphocholine 
• 57-11-4 stearic acid 
• 816-94-4 {2-[(2,3-bis-stearoyloxy-propoxy)-hydroxy-phosphoryloxy]-ethyl}-trimethyl-ammonium betaine 
• 98819-78-4 1,2-dieicosapentanoylglycero-3-phophocholine 
• 273931-53-6 C₃₂H₅₃N₂O₁₂P 

Relevant articles and documents

Phospholipid Synthesis Based on New Sequential Phosphate and Carboxylate Ester Bond Formation Steps

A total synthesis of racemic phosphatidylcholine is based on two novel but straightforward reaction sequences.The phosphate diester portion is constructed by successive displacement of the chlorines on methyl dichlorophosphate by allyl alcohol and dimethylethanolamine.The resulting triester isomerizes smoothly to allyl choline phosphate.The double bond is then converted to the bromohydrin to allow the sequential introduction of the two acyl ester linkages.Esterification of the hydroxyl with palmitoyl chloride produces 2-bromo-2-deoxylysophosphatidylcholine as the only isomer.The bromide is displaced in the final step upon treatment with the carboxylate form of an anion-exchange resin.The distinctive 31P-13C coupling patterns in the 13C resonances of the glycerol backbone allow the regiochemistry of the various steps to be conveniently monitored.Also, employment of palmitic-1-13C acid in the final step indicated a 70percent rearrangement accompanied formation of the mixed acid phosphatidylcholine.

Method for Preparation of Choline alfoscerate

The present invention relates to a method for preparing a choline alfoscerate useful for the treatment of brain dysfunction caused by cerebrovascular diseases economically through a process suitable for mass production, and more particularly, to the method for preparing the choline alfoscerate, which comprises the following steps: (A) reacting phosphorylcholine chloride calcium salt with potassium oxalate to prepare an alkali metal-substituted salt; and (B) preparing the choline alfoscerate by a reaction of the alkali metal-substituted salt with (R)-(+)-3-chloro-1,2-propanediol.COPYRIGHT KIPO 2018

A rapid condensation between lysophosphorylcholine and fatty acids with an easily separable amine base

With 2,6-Cl2C6H3COCl and 1-methylimidazole, the title condensation completed at room temperature within 12 hours, which is shorter time than that with the standard DCC/DMAP system. Use of easily separable 1-methylimidazole from the crude product by chromatography is an additional advantage of the present reagent system. Georg Thieme Verlag Stuttgart.