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Cas Database

350-46-9

350-46-9

Identification

  • Product Name:4-Fluoronitrobenzene

  • CAS Number: 350-46-9

  • EINECS:206-502-8

  • Molecular Weight:141.102

  • Molecular Formula: C6H4FNO2

  • HS Code:2904.90

  • Mol File:350-46-9.mol

Synonyms:1-Fluoro-4-nitrobenzene;1-Nitro-4-fluorobenzene;4-Fluoro-1-nitrobenzene;4-Nitro-1-fluorobenzene;4-Nitrofluorobenzene;4-Nitrophenyl fluoride;Benzene,1-fluoro-4-nitro-;Para-fluoronitrobenzene;p-Fluoronitrobenzene;p-Nitrofluorobenzene;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn

  • Hazard Codes:Xn,T,Xi

  • Signal Word:Danger

  • Hazard Statement:H301 Toxic if swallowedH312 Harmful in contact with skin H317 May cause an allergic skin reaction H331 Toxic if inhaled H373 May cause damage to organs through prolonged or repeated exposure H412 Harmful to aquatic life with long lasting effects

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:4-Nitrofluorobenzene
  • Packaging:25g
  • Price:$ 55
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Fluoronitrobenzene >98.0%(GC)
  • Packaging:500g
  • Price:$ 111
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Fluoronitrobenzene >98.0%(GC)
  • Packaging:100g
  • Price:$ 43
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Fluoronitrobenzene >98.0%(GC)
  • Packaging:25g
  • Price:$ 22
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Fluoronitrobenzene 99%
  • Packaging:250 g
  • Price:$ 29
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Fluoronitrobenzene 99%
  • Packaging:1 kg
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:1-Fluoro-4-nitrobenzene 99%
  • Packaging:100g
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:1-Fluoro-4-nitrobenzene 99%
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  • Manufacture/Brand:Medical Isotopes, Inc.
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Relevant articles and documentsAll total 162 Articles be found

Method for synthesizing nitro (hetero) aromatic hydrocarbon

-

Paragraph 0082-0084; 0097-0099, (2022/04/08)

The invention discloses a method for synthesizing nitro (hetero) aromatic hydrocarbon, and belongs to the field of organic synthesis. According to the method, simple (hetero) aromatic hydrocarbon is taken as an initial raw material and is stirred and reacted in an organic solvent at 40-100 DEG C under the action of a nitration reagent, a lewis acid catalyst and protective gas, and nitro (hetero) aromatic hydrocarbon can be obtained. The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good chemical selectivity, wide substrate application range, easy amplification and the like, has great application potential, and lays a good foundation for industrial production.

Ipso Nitration of Aryl Boronic Acids Using Fuming Nitric Acid

Baucom, Kyle D.,Brown, Derek B.,Caille, Seb,Murray, James I.,Quasdorf, Kyle,Silva Elipe, Maria V.

supporting information, (2021/06/30)

The ipso nitration of aryl boronic acid derivatives has been developed using fuming nitric acid as the nitrating agent. This facile procedure provides efficient and chemoselective access to a variety of aromatic nitro compounds. While several activating agents and nitro sources have been reported in the literature for this synthetically useful transformation, this report demonstrates that these processes likely generate a common active reagent, anhydrous HNO3. Kinetic and mechanistic studies have revealed that the reaction order in HNO3 is >2 and indicate that the ?NO2 radical is the active species.

The polyhedral nature of selenium-catalysed reactions: Se(iv) species instead of Se(vi) species make the difference in the on water selenium-mediated oxidation of arylamines

Capperucci, Antonella,Dalia, Camilla,Tanini, Damiano

supporting information, p. 5680 - 5686 (2021/08/16)

Selenium-catalysed oxidations are highly sought after in organic synthesis and biology. Herein, we report our studies on the on water selenium mediated oxidation of anilines. In the presence of diphenyl diselenide or benzeneseleninic acid, anilines react with hydrogen peroxide, providing direct and selective access to nitroarenes. On the other hand, the use of selenium dioxide or sodium selenite leads to azoxyarenes. Careful mechanistic analysis and 77Se NMR studies revealed that only Se(iv) species, such as benzeneperoxyseleninic acid, are the active oxidants involved in the catalytic cycle operating in water and leading to nitroarenes. While other selenium-catalysed oxidations occurring in organic solvents have been recently demonstrated to proceed through Se(vi) key intermediates, the on water oxidation of anilines to nitroarenes does not. These findings shed new light on the multifaceted nature of organoselenium-catalysed transformations and open new directions to exploit selenium-based catalysis.

Method for pipeline continuous fluorination with fluorine salt as fluorine source

-

Paragraph 0056-0091; 0095-0096; 0098; 0100-0105, (2021/10/27)

The method comprises the following steps: dissolving a fluorine salt in an aqueous polar aprotic solvent as reaction liquid A, dissolving an aryl (heterocyclic) chloride in a polar aprotic solvent as reaction liquid B, and reacting a polar aprotic solvent in the reaction liquid A with a polar aprotic solvent of the reaction liquid B. The reaction medium consisting of the preheated reaction liquid A and the preheated reaction liquid B enters the reaction coil for a fluorination reaction, and the resulting product from the reaction coil is subjected to post-treatment to obtain the product. The method has the characteristics of no need of adding a phase transfer catalyst, continuous production, low production cost and the like.

Method for efficiently synthesizing fluorine-containing compound

-

Paragraph 0068-0070, (2021/06/26)

The invention discloses a method for efficiently synthesizing a fluorine-containing compound, and relates to the field of fluorine-containing compound synthesis. The method is a method for generating a corresponding fluorine atom substituted fluorine-containing compound by reacting aromatic chloride or activated chloride serving as a raw material with potassium fluoride under the action of a novel catalyst. The method disclosed by the invention has the advantages of good product selectivity, high efficiency, mild reaction conditions, simplicity and convenience in operation, convenience in application and the like.

Process route upstream and downstream products

Process route

4-nitro-aniline
100-01-6,104810-17-5

4-nitro-aniline

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

Conditions
Conditions Yield
4-nitro-aniline; With calcium fluoride; sulfuric acid; sodium nitrite; In dichloromethane; at 0 ℃; for 0.25h;
With water; In dichloromethane; at 55 ℃; for 2h;
46%
8 % Chromat.
3-chloro-3-(p-nitrophenoxy)diazirine
848768-04-7

3-chloro-3-(p-nitrophenoxy)diazirine

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

3-fluoro-3-(p-nitrophenoxy)diazirine

3-fluoro-3-(p-nitrophenoxy)diazirine

Conditions
Conditions Yield
With tetrabutyl ammonium fluoride; In [D3]acetonitrile; at 0 - 25 ℃; for 10h;
28%
3-chloro-3-(p-nitrophenoxy)diazirine
848768-04-7

3-chloro-3-(p-nitrophenoxy)diazirine

carbon monoxide
201230-82-2

carbon monoxide

3-chloro-3-fluoro-3H-diazirine
4823-42-1

3-chloro-3-fluoro-3H-diazirine

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

3-fluoro-3-(p-nitrophenoxy)diazirine

3-fluoro-3-(p-nitrophenoxy)diazirine

Conditions
Conditions Yield
With tetrabutyl ammonium fluoride;
nitrobenzene
98-95-3,26969-40-4

nitrobenzene

3-fluoro-1-nitrobenzene
402-67-5

3-fluoro-1-nitrobenzene

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

1,4-difluoro-2-nitrobenzene
364-74-9

1,4-difluoro-2-nitrobenzene

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

ortho-nitrofluorobenzene
1493-27-2,127723-77-7

ortho-nitrofluorobenzene

Conditions
Conditions Yield
With xenon difluoride; boron trifluoride diethyl etherate; at 0 - 25 ℃; Reagent/catalyst; Cooling with ice;
0.05 mmol
0.16 mmol
0.01 mmol
0.016 mmol
0.001 mmol
4-nitrophenyl sulfurofluoridate
51451-34-4

4-nitrophenyl sulfurofluoridate

para-methoxynitrobenzene
100-17-4

para-methoxynitrobenzene

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

Conditions
Conditions Yield
With tetramethylammonium fluoride; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;
38%
para-methoxynitrobenzene
100-17-4

para-methoxynitrobenzene

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: fluorosulfonyl fluoride; triethylamine / 1,4-dioxane / 24 h / 20 °C
2: tetramethylammonium fluoride / N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere; Glovebox; Sealed tube
With fluorosulfonyl fluoride; tetramethylammonium fluoride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
C<sub>34</sub>H<sub>26</sub>N<sub>4</sub>O<sub>4</sub>PdS

C34H26N4O4PdS

benzo[h]quinolinyl(tetrapyrazolylborate)palladium(IV)fluoride trifluoromethanesulfonate

benzo[h]quinolinyl(tetrapyrazolylborate)palladium(IV)fluoride trifluoromethanesulfonate

4-fluoro-biphenyl
324-74-3

4-fluoro-biphenyl

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

Conditions
Conditions Yield
In dichloromethane; at 23 - 60 ℃; for 2h;
C<sub>34</sub>H<sub>26</sub>N<sub>4</sub>O<sub>4</sub>PdS

C34H26N4O4PdS

7-nitrobenzo[h]quinolinyl(tetrapyrazolylborate)palladium(IV)fluoride trifluoromethanesulfonate

7-nitrobenzo[h]quinolinyl(tetrapyrazolylborate)palladium(IV)fluoride trifluoromethanesulfonate

4-fluoro-biphenyl
324-74-3

4-fluoro-biphenyl

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

Conditions
Conditions Yield
In dichloromethane; at 23 - 60 ℃; for 2h;
C<sub>25</sub>H<sub>21</sub>BFN<sub>9</sub>Pd

C25H21BFN9Pd

C<sub>34</sub>H<sub>26</sub>N<sub>4</sub>O<sub>4</sub>PdS

C34H26N4O4PdS

4-fluoro-biphenyl
324-74-3

4-fluoro-biphenyl

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

Conditions
Conditions Yield
In dichloromethane; at 60 ℃; for 2h;
C<sub>25</sub>H<sub>20</sub>BFN<sub>10</sub>O<sub>2</sub>Pd

C25H20BFN10O2Pd

C<sub>34</sub>H<sub>26</sub>N<sub>4</sub>O<sub>4</sub>PdS

C34H26N4O4PdS

4-fluoro-biphenyl
324-74-3

4-fluoro-biphenyl

4-Fluoronitrobenzene
350-46-9,178603-76-4

4-Fluoronitrobenzene

Conditions
Conditions Yield
In dichloromethane; at 60 ℃; for 2h;

Global suppliers and manufacturers

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  • COLORCOM LTD.
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