3724-10-5Relevant articles and documents
Rearrangements in the Molecular Ion of o-(Methyl-d3-thio)benzoic acid: Comparison with o-Methoxy-d3-benzoic Acid
Gillis, Richard G.,Porter, Quentin N.
, p. 543 - 545 (1985)
Hydrogen/deuterium exchange and rearrangements in the molecular ion of o-(methyl-d3-thio)benzoic acid lead to fragment ions + as well as + and m/z 106 and 107, just as in the molecular ion of o-methoxybenzoic a
Photocatalytic Deoxygenation of Sulfoxides Using Visible Light: Mechanistic Investigations and Synthetic Applications
Clarke, Aimee K.,Parkin, Alison,Rossi-Ashton, James A.,Taylor, Richard J. K.,Unsworth, William P.
, p. 5814 - 5820 (2020/07/21)
The photocatalytic deoxygenation of sulfoxides to generate sulfides facilitated by either Ir[(dF(CF3)ppy)2(dtbbpy)]PF6 or fac-Ir(ppy)3 is reported. Mechanistic studies indicate that a radical chain mechanism operates, which proceeds via a phosphoranyl radical generated from a radical/polar crossover process. Initiation of the radical chain was found to proceed via two opposing photocatalytic quenching mechanisms, offering complementary reactivity. The mild nature of the radical deoxygenation process enables the reduction of a wide range of functionalized sulfoxides, including those containing acid-sensitive groups, in typically high isolated yields.
INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR
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Paragraph 0078-0079, (2019/06/07)
The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.