378-75-6

Basic information

• Product Name: Methyl pentafluoropropionate
• Synonyms: PERFLUOROPROPIONIC ACID METHYL ESTER;PENTAFLUOROPROPIONIC ACID METHYL ESTER;2,2,3,3,3-Pentafluoro-propionic acid methyl ester;methylesterkyselinypentafluorpropionove;pentafluoro-propanoicacimethylester;pentafluoro-propionicacimethylester;METHYL PENTAFLUOROPROPIONATE;METHYL PERFLUOROPROPIONATE
• CAS NO: 378-75-6
• Molecular Formula: C₄H₃F₅O₂
• Molecular Weight: 178.06
• EINECS: 206-828-0
• Product Categories: C2 to C5;Carbonyl Compounds;Esters;Halogenated Heterocycles ,Pyrimidines
• Mol File: 378-75-6.mol

Chemical Properties

• Boiling Point: 61 °C739 mm Hg(lit.)
• Flash Point: 42 °F
• Appearance: clear colorless liquid
• Density: 1.393 g/mL at 25 °C(lit.)
• Vapor Pressure: 8.29mmHg at 25°C
• Refractive Index: n20/D 1.288(lit.)
• Storage Temp.: Flammables area
• BRN: 1777501
• CAS DataBase Reference: Methyl pentafluoropropionate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl pentafluoropropionate(378-75-6)
• EPA Substance Registry System: Methyl pentafluoropropionate(378-75-6)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-37/39
• RIDADR: UN 3272 3/PG 2
• WGK Germany: 2
• RTECS: UF6475500
• TSCA: T
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 378-75-6(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C6F10O2/c7-1(17)3(9,10)5(13,14)6(15,16)4(11,12)2(8)18

Upstream product

• 67-56-1 methanol 
• 422-64-0 pentafluoropropionic acid 
• 2544-06-1 3-Methoxypropionic acid 
• 428-59-1 Hexafluoropropene oxide 
• 124008-11-3 Perfluoro<3-(N,N-dimethylamino)propionyl> fluoride 
• 1584-03-8 perfluoro-2-methylpent-2-ene 
• 2070-70-4 perfluoro-4-methyl-2-pentene 
• 123202-05-1 Sodium; 2,3,3,3-tetrafluoro-2-methoxy-propionate 
• 378-77-8 sodium pentafluoropropionate 
• 422-61-7 perfluoropropanoyl fluoride 
• 100-39-0 benzyl bromide 
• 121-44-8 triethylamine 
• 64-17-5 ethanol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 354-76-7 2,2,3,3,3-pentafluoropropionamide 
• 337-33-7 1,1-diphenyl-2,2,3,3,3-pentafluoropropan-1-ol 
• 680-14-8 Pentafluorpropionsaeurehydrazid 
• 2145-82-6 2-(pentafluoropropionyl)cyclohexanone 
• 1799-50-4 4,4,5,5,5-pentafluoro-1-phenyl-pentane-1,3-dione 
• 378-77-8 sodium pentafluoropropionate 
• 345-40-4 2,2,3,3,3-Pentafluoro-1-phenyl-propan-1-ol 
• 394-52-5 pentafluoroethyl phenyl ketone 
• 77146-65-7 2,2,3,3,3-Pentafluoro-propionic acid N'-phenyl-hydrazide 
• 374-46-9 2-methyl-3,3,4,4,4-pentafluorobutan-2-ol 
• 663-35-4 ethylpentafluoropropionylacetate 
• 14038-06-3 1-methoxy-4-(pentafluoroethyl)benzene 
• 52447-16-2 pentafluoroethyl pentafluorophenyl ketone 
• 20825-07-4 1,1,1,5,5,6,6,6-octafluorohexane-2,4-dione 

Relevant articles and documents

Novel Fire Retardant Compounds

Compounds with fire extinguishing properties having the formula: wherein R1 is —CR5R6R7 or —CR5R6CR8R9R10 as well as fire extinguishing units including one or more of the compounds.

One stone two birds: Degradation of persistent organic pollutants to a valuable industrial chemical production of pentafluoropropionyl fluoride from HFPO oligomers catalyzed by cesium fluoride in tetraglyme

Hexafluoropropylene oxide (HFPO) oligomers are toxic, bioaccumulative, and persistent organic pollutants (POPs). Consuming the harmful chemicals to prevent them from releasing to nature is of serious significance as far as both natural environments and human health are concerned. In this study, investigation on degradation of HFPO oligomers to pentafluoropropionyl fluoride (PPF), a valuable industrial chemical, is reported. Different combinations of alkali metal fluoride in either diglyme or tetraglyme under both flask and batch autoclave conditions were examined. Under the optimal reaction conditions, HFPO oligomers (n?=?2–10) were completely degraded to PPF in over 90% yield. Reactions on 200?g scale were tested and no deduction of efficiency was observed, which indicates the potential for practical industrial application of this chemistry.

New catalytic alkylation of in situ generated perfluoro-alkyloxy-anions and perfluoro-carbanions

Alkyl fluoroformates RHOC(O)F are a new family of excellent alkylating agents. Perfluoroacyl fluorides, selected perfluoroketones and fluoroolefins can be alkylated to hydrofluoroethers RF-O-R H and hydrofluoroalkanes RF-RH, respectively. Potassium fluoride and cesium fluorides catalysts in glymes at 50-100°C are the preferred experimental conditions.

Perfluoroalcohols

Perfluorinated primary alcohol adducts with triethylamine were prepared from lower perfluorinated acid fluorides and triethylamine monohydrofluoride. They are stable compounds and may be used as a source of RFO groups in organic syntheses.

Synthesis of perfluorinated dialkyl ethers from products of reaction of hexafluoropropene dimers with methanol

Perfluoro-2-methyl-2-pentene reacts with methanol in tetrahydrofuran and acetone in the presence of KOH to form predominantly the product of fluorine substitution at the double bond, whereas perfluoro-4-methyl-2-pentene reacts with methanol on heating in tetrahydrofuran in the presence of KOH or triethylamine with incorporation of two or three methoxy groups. Gas-phase fluorination of 3-methoxyperfluoro-2-methyl-2-pentene and 3-methoxyperfluoro-2-methylpentane with elemental fluorine on catalysts is studied, and conditions for preparing perfluoro-2-methyl-3-methoxypentane are revealed.

Oligomerization of nitrogen-containing perfluoroacyl fluorides with hexafluoropropene oxide

The ionic oligomerization of eight nitrogen-containing perfluoroacyl fluorides with hexafluoropropene oxide (HFPO) has been investigated.The 1:1 adducts of the acyl fluorides and HFPO were obtained in good yield except for the cases of 1f, 1g and 1h.The difference in the reactivity of two isomers (1e and 1f) is discussed in terms of the nucleophilicity of the alkoxide formed from them on the basis of the molecular orbital calculations.

UNUSUAL REACTION CHEMISTRY IN THERMAL DECOMPOSITION OF ALKALI METAL 2-ALKOXY-2,3,3,3-TETRAFLUOROPROPIONATE SALTS

Pyrolyses of several salts ROCF(CF3)CO2(-)M(+) (R=Me, Et, CF3CH2; M=Na, K, Cs) have been studied.The reaction chemistry shows highly unusual dependence on the nature of the alkoxy substituent and the metal cation.Product distribution are described along with some proposed mechanisms.

SYNTHESIS AND TRANSFORMATIONS OF PERFLUORO(2,4-DIMETHYL-3-HEPTENE) OXIDE

The oxidation of perfluoro(2,4-dimethyl-3-heptene) was realized with aqueous solutions of sodium hypohalites.The reaction of the obtained perfluoro(2,4-dimethyl-3-heptene) oxide with nucleophilic and electrophilic reagents was studied.Attack on the epoxide ring of perfluoro(2,4-dimethyl-3-heptene) oxide is hindered with increase in the size of the nucleophile.Perfluoro(2,4-dimethyl-3-heptene) oxide exhibits high stability toward electrophiles.