39890-95-4

Basic information

• Product Name: 2-Chloro-6-(trifluoromethyl)pyridine
• Synonyms: 2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDINE;BUTTPARK 27\08-82;PYRIDINE, 2-CHLORO-6-(TRIFLUOROMETHYL)-;6-Chloro-2-(trifluoromethyl)pyridine;2-CHLORO-6-TRIFLUOROMETHYLPRIDINE;2-Chloro-5-trifluoromethylpyri;2-CHLORO-6-TRIFLUOROMETHYL-PYRIDINE >97%;6-Chloro-alpha,alpha,alpha-trifluoro-2-picoline
• CAS NO: 39890-95-4
• Molecular Formula: C₆H₃ClF₃N
• Molecular Weight: 181.54
• EINECS: -0
• Product Categories: Halides;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines;Pyridine;Pyridines derivates;Pyridine series;Chloropyridines;Halopyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Fluorine series;alkyl chloride
• Mol File: 39890-95-4.mol

Chemical Properties

• Melting Point: 33 °C
• Boiling Point: 60-62°C 8mm
• Flash Point: 78°C
• Appearance: Colorless to off-white liquid (or White to off-white crystal)
• Density: 1.417 g/cm³
• Vapor Pressure: 5.598mmHg at 25°C
• Refractive Index: 1.447
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -4.30±0.10(Predicted)
• Water Solubility: Insoluble in water
• BRN: 4308910
• CAS DataBase Reference: 2-Chloro-6-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-(trifluoromethyl)pyridine(39890-95-4)
• EPA Substance Registry System: 2-Chloro-6-(trifluoromethyl)pyridine(39890-95-4)

Safety Data

• Hazard Codes: T;Xn,Xi,Xn,T
• Statements: 25-20/21/22-36/37/38-36
• Safety Statements: 26-36/37/39-45-36/37-9-36
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 39890-95-4(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to off-white liquid (or White to off-white crystal)

InChI:InChI=1/C6H3ClF3N/c7-5-3-1-2-4(11-5)6(8,9)10/h1-3H

Upstream product

• 34486-24-3 2-amino-6-(trifluoromethyl)pyridine 
• 1929-82-4 nitrapyrin 
• 5140-72-7 2-bromo-6-chloro-pyridine 
• 626-05-1 2,6-Dibromopyridine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 258506-66-0 2-chloro-5-iodo-pyridine 

Downstream Products

• 94239-04-0 2-fluoro-6-(trifluoromethyl)pyridine 
• 1422457-66-6 [2-[(cis-4-{3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-1-yl}cyclohexyl)oxy]-6-(trifluoromethyl)pyridin-4-yl]methyl methanesulfonate 
• 1422457-63-3 {1-(cis-4-{[4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile 
• 1422457-64-4 {1-(cis-4-{[4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile 
• 1422457-62-2 4-{[4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone 
• 917396-39-5 [2-chloro-6-(trifluoromethyl)pyridin-3-yl]methanol 
• 280566-45-2 2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid 
• 796090-23-8 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylic acid 
• 1000565-32-1 [6-(trifluoromethyl)-2-pyridinyl]acetic acid 
• 1321517-91-2 2-trideuteromethyl-6-(trifluoromethyl)pyridine 
• 1262193-70-3 N-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazol-5-yl]-6-(trifluoromethyl)-2-pyridinamine 
• 879609-99-1 2-chloro-3-(tributylstannyl)-6-(trifluoromethyl)pyridine 
• 155377-05-2 6-(trifluoromethyl)pyridine-2-carboxylic acid methyl ester 
• 945717-57-7 6-chloro-3-iodo-2-(trifluoromethyl)pyridine 

Relevant articles and documents

Method for preparing 2-hydroxy-6-(trifluoromethyl) pyridine

The invention relates to a method for preparing 2-hydroxy-6-(trifluoromethyl) pyridine. The method comprises the following steps: (1) adding 2-amino-6-(trifluoromethyl) pyridine into concentrated hydrochloric acid, dropwise adding a sodium nitrite solution after the heating reaction is ended so as to obtain a diazonium salt solution; (2) adding cuprous chloride solids into the hydrochloric acid solution, heating, dropwise adding the above diazonium salt solution, maintaining the temperature for reacting, regulating the pH value of the reaction solution after the reaction is ended, extracting the organic layer, and removing ethyl acetate in the organic layer solution so as to obtain solids; (3) adding potassium hydroxide and the solids prepared in the step (2) into tert-butyl alcohol, raising the temperature for reacting, removing the tert-butyl alcohol after the reaction is ended, adding ethyl acetate and water and stirring, regulating the pH value, and taking the organic layer so as to obtain a crude product; and (4) recrystallizing the crude product prepared in the step (3) with ethyl acetate and petroleum ether, thereby obtaining the finished product. The method disclosed by the invention has the advantages of mild reaction conditions, low equipment requirement and high yield.

PROCESS FOR THE PREPARATION OF HALOSUBSTITUTED TRIFLUOROMETHYLPYRIDINES

The present invention provides a process for the preparation of halosubstituted-6-trifluoromethyl pyridine of Formula (I) wherein X is a halogen

PROCESS FOR PRODUCING 2-FLUORO-6-(TRIFLUOROMETHYL)PYRIDINE COMPOUNDS

The present invention relates to an industrially feasible and economically viable process for the preparation of 2-fluoro-6-(trifluoromethyl)pyridine compounds of Formula (I). The process comprises fluorination of one or more pyridine compounds of Formula (II) with a fluorinating agent and isolating 2-fluoro-6-(trifluoromethylpyridine compound of Formula (I) obtained, which are useful as intermediates in the synthesis of many agrochemical and pharmaceutical products.

Trifluoromethyl-substituted pyridines through displacement of iodine by in situ generated (trifluoromethyl)copper

A literature method reported for iodobenzene and congeners was successfully extended to the pyridine series. 2-Iodopyridines can be converted into 2-(trifluoromethyl)pyridines almost quantitatively. In contrast, yields are moderate at best if 3- and 4-iodopyridines or 2-bromopyridines are used as the starting materials. WILEY-VCH Verlag GmbH 2002.