42142-52-9

Basic information

• Product Name: 3-Hydroxy-N-methyl-3-phenyl-propylamine
• Synonyms: ALPHA-(2-METHYLAMINO)-ETHYLBENZENEMETHANOL;ALPHA-[2-(METHYLAMINO)ETHYL]BENZYL ALCOHOL;3-HYDROXY-N-METHYL-3-PHENYLPROPYLAMINE;3-METHYLAMINO-1-PHENYLPROPANOL;3-(METHYLAMINO)-1-PHENYLPROPAN-1-OL;3-METHYLAMINO-1-PHENYL-1-PROPANOL;N-METHYL-3-PHENYL-3-HYDROXYPROPYLAMINE;N-METHYL-3-HYDROXY-3-PHENYL PROPYLAMINE
• CAS NO: 42142-52-9
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.23
• EINECS: 255-679-8
• Product Categories: INTERMEDIATESOFFLUOXETINE;Intermediates of Fluoxetine;Amino Alcohols;Organic Building Blocks;Oxygen Compounds;Amino Alcohols;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 42142-52-9.mol
• Article Data: 24

Chemical Properties

• Melting Point: 64 °C
• Boiling Point: 170 °C / 31mmHg
• Flash Point: 114.8 °C
• Appearance: /
• Density: 1.017 g/cm³
• Vapor Pressure: 0.00126mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Soluble), Methanol (Slightly)
• PKA: 14.24±0.20(Predicted)
• CAS DataBase Reference: 3-Hydroxy-N-methyl-3-phenyl-propylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-N-methyl-3-phenyl-propylamine(42142-52-9)
• EPA Substance Registry System: 3-Hydroxy-N-methyl-3-phenyl-propylamine(42142-52-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 42142-52-9(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 42142-52-9 differently. You can refer to the following data:
1. 3-Hydroxy-N-methyl-3-phenyl-propylamine is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.
2. α-[2-(Methylamino)ethyl]benzyl Alcohol (Fluoxetine EP Impurity A(Atomoxetine Related Compound A)) is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.This compound is found as an impurity in fluoxetine (F597100).

InChI:InChI=1/C10H15NO/c1-11-8-7-10(12)9-5-3-2-4-6-9/h2-6,10-12H,7-8H2,1H3/p+1/t10-/m1/s1

Upstream product

• 21970-65-0 3-(benzyl-methyl-amino)-1-phenylpropan-1-one 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 74681-55-3 3-(N-benzyl-N-methylamino)-1-phenyl-propan-1-ol 
• 768-03-6 Phenyl vinyl ketone 
• 74-89-5 methylamine 
• 108606-85-5 N-[(3-phenylprop-2-en)methylene]-α-phenylbenzenemethanamine 
• 104-55-2 3-phenyl-propenal 
• 62872-58-6 3-iodo-1-phenyl-propan-1-ol 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 
• 936-59-4 3-chloropropiophenone 
• 5409-62-1 3-(benzyl methylamino)-1-phenylpropan-1-one hydrochloride 
• 68408-65-1 2-methyl-5-phenyl-isoxazolidine 
• 877-50-9 3-(methylamino)-1-phenylprop-2-en-1-one 
• 98-86-2 acetophenone 

Downstream Products

• 19798-87-9 tetrahydro-3-methyl-6-phenyl-2H-1,3-oxazine 
• 1939-17-9 N-<3-Phenyl-propin-(2)-yl>-N-<3-hydroxy-3-phenyl-propyl>-methylamin 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 98-86-2 acetophenone 
• 768-03-6 Phenyl vinyl ketone 
• 693262-07-6 (+/-) ethyl 3-[N-methyl-N-(3-hydroxy-3-phenylpropyl)]aminopropionate 
• 871351-42-7 trifluoroacetic acid 3-[methyl-(2,2,2-triffuoro-acetyl)-amino]-1-phenyl-propyl ester 
• 357405-72-2 [3-(2-Chloro-5-nitrophenoxy)-3-phenylpropyl]methylcarbamic acid 1,1-dimethylethyl ester 
• 873310-33-9 N-methyl-3-phenoxy-3-phenyl-propylamine hydrochloride 
• 1254704-84-1 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol 
• 1254705-32-2 N-methyl-3-phenyl-3-(7-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-yloxy)propan-1-amine 
• 1254705-33-3 4-(3-(methylamino)-1-phenylpropyl)-7-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol 
• 1265906-84-0 2-(3-(methylamino)-1-phenylpropyl)phenol 

Relevant articles and documents

Manganese-Catalyzed Anti-Markovnikov Hydroamination of Allyl Alcohols via Hydrogen-Borrowing Catalysis

Controlling the selectivity in a hydroamination reaction is an extremely challenging yet highly desirable task for the diversification of amines. In this article, a selective formal anti-Markovnikov hydroamination of allyl alcohols is presented. It enables the versatile synthesis of valuable γ-amino alcohol building blocks. A phosphine-free Earth's abundant manganese(I) complex catalyzed the reaction under hydrogen-borrowing conditions. A vast range of aliphatic, aromatic amines, drug molecules, and natural product derivatives underwent successful hydroamination with primary and secondary allylic alcohols with excellent functional group tolerance (57 examples). The catalysis could be performed on a gram scale and has been applied for the synthesis of drug molecules. The mechanistic studies revealed the metal-ligand bifunctionality as well as hemilability of the ligand backbone as the key design principle for the success of this catalysis.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

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