450-95-3

Basic information

• Product Name: 2'-FLUOROACETOPHENONE
• Synonyms: O-FLUOROACETOPHENONE;LABOTEST-BB LT01148268;2-fluoro-1-phenylethan-1-one;Phenacyl fluoride;Ethanone, 2-fluoro-1-phenyl- (9CI);1-Phenyl-2-fluoroethanone;α-Fluoroacetophenone;2-fluoro-1-phenylethanone
• CAS NO: 450-95-3
• Molecular Formula: C₈H₇FO
• Molecular Weight: 138.14
• EINECS: 207-156-0
• Product Categories: ACETYLHALIDE
• Mol File: 450-95-3.mol
• Article Data: 98

Chemical Properties

• Melting Point: 26-27
• Boiling Point: 187-189 °C(lit.)
• Flash Point: 143 °F
• Appearance: /
• Density: 1.137 g/mL at 20 °C(lit.)
• Refractive Index: n20/D 1.507(lit.)
• CAS DataBase Reference: 2'-FLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-FLUOROACETOPHENONE(450-95-3)
• EPA Substance Registry System: 2'-FLUOROACETOPHENONE(450-95-3)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 450-95-3(Hazardous Substances Data)

Usage

Uses

2-Fluoroacetophenone is used in method for synthesizing -Fluorinated Ketone by hydrazonation of fatty chain monoketone.

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 4137, 1954 DOI: 10.1021/ja01645a025Tetrahedron Letters, 28, p. 4733, 1987 DOI: 10.1016/S0040-4039(00)96612-7

InChI:InChI=1/C8H7FO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2

Upstream product

• 359-06-8 monofluoroacetyl chloride 
• 71-43-2 benzene 
• 74-86-2 acetylene 
• 1885-29-6 anthranilic acid nitrile 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 
• 79-37-8 oxalyl dichloride 
• 996-50-9 N,N-diethyl-1,1,1-trimethylsilanamine 
• 1068-55-9 isopropylmagnesium chloride 
• 765-43-5 Cyclopropyl methyl ketone 
• 67-56-1 methanol 
• 536-74-3 phenylacetylene 
• 1046785-30-1 1-(2-fluoro-1,1-dimethoxyethyl)-benzene 
• 614-20-0 3-oxo-3-phenylpropionic acid 

Downstream Products

• 3240-29-7 1-Phenylpent-4-en-1-one 
• 191084-01-2 3-fluoro-2-phenylquinoline-4-carboxylic acid 
• 50781-28-7 2-oxo-2-phenyl-ethyl 
• 7228-40-2 1-(benzo[d][1,3]dioxol-4-yl)ethanol 
• 133463-64-6 Ethyl 3-(2-isobutyrylphenylamino)-3-oxopropanoate 
• 131513-26-3 3-(4-morpholinylmethyl)-5-methyl-6-(2-fluorobenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine methanesulfonate 
• 98-85-1 1-Phenylethanol 
• 1341230-63-4 2-fluoro-1,2,2-triphenylethan-1-one 
• 720-43-4 2-fluoro-1,2-diphenylethanone 
• 1612838-57-9 2-fluoro-1-phenyl-2-(p-tolyl)ethan-1-one 

Relevant articles and documents

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Synthesis method of alpha or beta-substituted aromatic ketone

The invention discloses a synthesis method of alpha-or beta-substituted aromatic ketone. The method comprises the following steps: under the condition of inert gas, reacting alpha-oxo-aryl ethanone compounds, B2pin2, PDI-CoCl2 and MBHEt3 in an organic solvent at room temperature, then adding a compound 2, and continuously reacting to obtain a compound 3, wherein in the MBHEt3, M is an alkali metal; the compound 2 is selected from the group consisting of deuterated methanol, Selectfluoro, a TogniII reagent or R2CHO; R2 is an aromatic substituent or alkyl; the organic solvent is an aprotic organic solvent. According to the method, the alpha-oxo aryl ethanone is used as a raw material, a cheap and stable boron reagent and an efficient cobalt catalyst which is cheap and easy to obtain are used, an activating reagent MBHEt3 is added to generate an enol boron ether intermediate, then the enol boron ether intermediate and different electrophilic reagents are synthesized into alpha-or beta-substituted aromatic ketone, the reaction is carried out at normal temperature, and the operation is convenient.

Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride

An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerates nucleophilic fluorinations using easy handling KF. We also successfully converted an inexpensive and commercially available ion-exchange resin to the polymer-supported ion pair promoter (A26–SO42–), which could be reused after filtration. Moreover, A26–SO42– can be used in continuous flow conditions. In our conditions, water is well-tolerated.

LINKING AMINO ACID SEQUENCES, MANUFACTURING METHOD THEREOF, AND USE THEREOF

This invention provides compositions comprising linked amino acid sequences, pharmaceutical compositions comprising linked amino acid sequences, and methods of making thereof. This invention also provides methods of delivering said compositions to subjects and methods of treating various disorders and diseases using the said compositions.