452-63-1

Basic information

• Product Name: 2-Bromo-5-fluorotoluene
• Synonyms: 1-BROMO-4-FLUORO-2-METHYLBENZENE;2-BROMO-5-FLUOROTOLUENE;3-FLUORO-6-BROMOTOLUENE;Benzene, 1-bromo-4-fluoro-2-methyl-;2-Bromo-5-fuluorotoluene;2-Bromo-5-fluorotoluene,98+%;2-Bromo-5-fluorotoluene 98%;2-BROMO-5-FULUOROTOLRENE
• CAS NO: 452-63-1
• Molecular Formula: C₇H₆BrF
• Molecular Weight: 189.02
• EINECS: 207-203-5
• Product Categories: Fluorin-contained toluene series;Fluorobenzene;Fluoro-Aromatics;Aromatic Halides (substituted);Halogen toluene;API intermediates;Miscellaneous;Bromine Compounds;Fluorine Compounds;Benzenes;Aryl;C7;Halogenated Hydrocarbons;alkyl bromide | alkyl Fluorine
• Mol File: 452-63-1.mol

Chemical Properties

• Boiling Point: 177 °C756 mm Hg(lit.)
• Flash Point: 113 °F
• Appearance: colorless to light yellow liquid
• Density: 1.495 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.8mmHg at 25°C
• Refractive Index: n20/D 1.526(lit.)
• Storage Temp.: Flammables area
• Solubility: Difficult to mix.
• Water Solubility: INSOLUBLE
• BRN: 1859121
• CAS DataBase Reference: 2-Bromo-5-fluorotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-fluorotoluene(452-63-1)
• EPA Substance Registry System: 2-Bromo-5-fluorotoluene(452-63-1)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39-37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 452-63-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-Bromo-5-fluorotoluene is used as a chemical intermediate for the production of other chemicals. It is particularly utilized in the synthesis of 2-Bromo-5-fluoro-benzoic acid, which is an important compound in various chemical and pharmaceutical applications.
The synthesis of 2-Bromo-5-fluoro-benzoic acid from 2-Bromo-5-fluorotoluene involves a reaction with the reagent potassium permanganate (KMnO4) in water (H2O) as the solvent, under conditions of heating. This reaction allows for the conversion of the toluene derivative into the desired benzoic acid, expanding the range of applications for the starting material and contributing to the development of new chemical products and pharmaceuticals.

InChI:InChI=1/C7H6BrF/c1-5-4-6(8)2-3-7(5)9/h2-4H,1H3

Upstream product

• 352-70-5 m-Fluorotoluene 
• 56-23-5 tetrachloromethane 
• 7726-95-6 bromine 
• 108-88-3 toluene 
• 6933-10-4 amino-5-bromo-2-toluene 
• 97815-02-6 hexafluorophosphate de bromo-4-methyl-3-benzene diazonium 

Downstream Products

• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 112399-50-5 2-bromo-5-fluorobenzyl bromide 
• 112399-51-6 2-bromo-5-fluorobenzal bromide 
• 170098-98-3 1-bromo-4-fluoro-2-methyl-5-nitro-benzene 
• 204505-31-7 1-(4-Fluoro-2-methyl-phenyl)-3-{2-[1-methoxy-meth-(Z)-ylidene]-cyclohexyl}-propan-1-one 
• 294204-21-0 1-bromo-4-fluoro-2-methyl-5-(methylsulfonyl)benzene 
• 112399-43-6 2-(2-bromo-5-fluorophenyl)-2-butanone 
• 112399-44-7 [3-(2-Bromo-5-fluoro-phenyl)-1-methyl-propyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine 
• 112399-46-9 [3-(2-Bromo-5-fluoro-phenyl)-1-methyl-propyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amine 
• 321-21-1 4-fluoro-2-methylbenzoic acid 
• 377084-02-1 C₁₀H₁₀FNO 
• 63082-45-1 4-fluoro-2-methylbenzaldehyde 
• 174603-40-8 3-(4-fluoro-2-methyl-phenyl)acrylic acid ethyl ester 
• 147754-12-9 4-fluoro-2-methylbenzonitrile 

Relevant articles and documents

Reactivity of alkali and alkaline earth metal tetrafluorobromates towards aromatic compounds and pyridine

The bromination activity of tetrafluorobromates of alkali and alkali-earth metals increases in the order KBrF4, CsBrF4, RbBrF4and Ba(BrF4)2. The most active tetrafluorobromate—Ba(BrF4)2is able to selectively brominate the deactivated aromatic compounds nitrobenzene and 4-nitrotoluene, but not the activated compounds benzene and toluene. In all cases bromination of methyl groups of methylbenzenes does not occur. Ba(BrF4)2forms the known complex C6H5N·BrF3when reacted with pyridine. Due to dilution by inert BaF2, this pyridine-based complex is air stable and can be considered as safer and more convenient reagent in comparison with the original fluorobromates; it can selectively brominate benzene and toluene in contrast with tetrafluorobromates.

HELICENES : SYNTHESE PHOTOCHIMIQUE DE FLUORO-1-PENTAHELICENES

1-Fluoropentahelicene and substituted derivatives have been synthesized by the photocyclodehydrogenation of 1,2-di(2-naphtyl) ethylenes (1) and 3-styrylphenanthrenes (2).In two cases (1a and 2d) the photocyclisations gave rise to benzo perylenes (7, 8, 23, 24) a reaction involving either the loss (8, 24) or the fluorine atom.The 1H-NMR spectra are described.

4'-Fluoro-4-{[4-(phenyl)cyclohexyl]amino}butyrophenones and the salts thereof

This invention relates to novel 4-phenylcyclohexylamines embraced by the formula SPC1 Wherein ? is a generic expression denoting cis and trans stereoconfiguration and mixtures thereof; R is selected from the group consisting of alkyl of from one through four carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, nitro and alkoxy of from one through four carbon atoms; R' and R1 are selected from the group consisting of hydrogen and alkyl of from one through four carbon atoms; R2 is selected from the group consisting of hydrogen, alkyl of from one through four carbon atoms, alkanoyl of from one through three carbon atoms, alkylsulfonyl of from one through three carbon atoms, arylsulfonyl of from six through ten carbon atoms, alkylcarbamoyl wherein alkyl is from one through four carbon atoms, alkoxycarbonyl wherein alkyl is from one through four carbon atoms, ring monosubstituted aroylalkyl wherein the substituents have the same meaning as R, above, aryl is from six through ten carbon atoms and alkyl is from one through six carbon atoms and bis (ring monosubstituted) arylalkyl wherein the substituents have the same meaning as R, above, aryl is from six through ten carbon atoms and alkyl is from one through six carbon atoms; R1 and R2 when taken together with --N is a saturated heterocyclic amino radical selected from the group consisting of unsubstituted and monosubstituted pyrrolidino, piperidino, hexamethylenimino, morpholino and piperazino; and an acid addition salt thereof. It also relates to intermediates and processes for the preparation of the aforesaid novel compounds (1) and novel derivatives thereof. The systemic administration to humans and animals of the novel compounds (1) depresses their central nervous systems.