4584-46-7Relevant articles and documents
A high-efficacy and regenerable antimicrobial resin containing quaternarized N-halamine groups
Jie, Zhiqiang,Yan, Xiufang,Zhao, Lianhong,Worley,Liang, Jie
, p. 1580 - 1587 (2013)
A novel macroporous cross-linked antimicrobial resin containing quaternarized N-halamine groups, poly(1-chloro-5,5-dimethylhydantoinyl-3-ethyl- p-ethenylphenylmethyl dimethylammonium chloride) (Cl-PSQH), has been synthesized by a facile three-step reaction. The as-prepared resins were characterized by FT-IR, X-ray photoelectron spectroscopy, and zeta-potential measurement. Antimicrobial tests showed that Cl-PSQH was capable of about a 7-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 1 min of contact. Also, its regenerability and preliminary storage stability were investigated.
RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Paragraph 00230; 00410; 00658, (2020/07/05)
Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.
Synthetic process of 2-dimethylaminoethyl chloride hydrochloride
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Paragraph 0015; 0020-0022, (2018/04/01)
The invention discloses a synthetic process of 2-dimethylaminoethyl chloride hydrochloride. The synthetic process comprises the following steps: taking dimethylethanolamine as a raw material, controlling the temperature to 10 to 15 DEG C and carrying out direct chlorination reaction on the dimethylethanolamine and thionyl chloride; adding absolute ethyl alcohol for carrying out a reflux reaction for one hour; filtering and drying to obtain a finished product. The synthetic process of the 2-dimethylaminoethyl chloride hydrochloride, provided by the invention, has the advantages of simple steps, high yield, good quality, low cost, mild reaction and convenience in operation; the purity of a product is high, i.e., the percentage of inorganic salt is less than 0.5 percent; three wastes are reduced, as hydrogen chloride gas and sulfur dioxide gas in the reaction are absorbed; a mother solution which is subjected to suction filtration does not need to be treated and is treated as waste liquid, so that environment protection is facilitated.