4603-59-2

Basic information

• Product Name: 3,6-DIMETHOXYPYRIDAZINE
• Synonyms: 3,6-DIMETHOXYPYRIDAZINE;Pyridazine, 3,6-diMethoxy-
• CAS NO: 4603-59-2
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.14
• Mol File: 4603-59-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 106 °C(Solv: water (7732-18-5))
• Boiling Point: 297.4°C at 760 mmHg
• Flash Point: 109.1°C
• Appearance: /
• Density: 1.131g/cm³
• Vapor Pressure: 0.00239mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.48±0.10(Predicted)
• CAS DataBase Reference: 3,6-DIMETHOXYPYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-DIMETHOXYPYRIDAZINE(4603-59-2)
• EPA Substance Registry System: 3,6-DIMETHOXYPYRIDAZINE(4603-59-2)

Safety Data

• Hazardous Substances Data: 4603-59-2(Hazardous Substances Data)

Usage

General Description

3,6-Dimethoxypyridazine is a chemical compound categorized under the group of pyridazines and its derivatives. This heterocyclic compound is characterized by its aromatic ring and two methoxy groups at the third and sixth positions. It is a solid, crystalline compound with a molar mass of 164.19 grams per mole. Although it currently has limited applications, it can potentially have significant impacts in various industries, including pharmaceuticals, manufacturing, and chemical synthesis due to its distinct chemical structure and reactivity. The chemical is often used in scientific research and, like all chemicals, should be handled with care.

InChI:InChI=1/C6H8N2O2/c1-9-5-3-4-6(10-2)8-7-5/h3-4H,1-2H3

Upstream product

• 123-33-1 6-hydroxy-3-pyridazinone 
• 77-78-1 dimethyl sulfate 
• 935-04-6 benzyl vinyl ether 
• 81930-31-6 3,6-bis(methoxy)-1,2,4,5-tetrazine 
• 67-56-1 methanol 
• 141-30-0 3,6-dichlorpyridazine 
• 124-41-4 sodium methylate 
• 262353-20-8 4,5-diiodo-3,6-dimethoxypyridazine 
• 623-49-4 ethyl cyanoformate 
• 262353-13-9 4-iodo-3,6-dimethoxypyridazine 
• 100-52-7 benzaldehyde 
• 75-77-4 chloro-trimethyl-silane 
• 64383-28-4 3-chloro-6-phenylsulfanyl-pyridazine 

Downstream Products

• 1015480-87-1 (3,6-dimethoxypyridazin-4-yl)boronic acid 
• 1190764-67-0 C₁₉H₁₆ClF₃N₄O₅S 
• 41374-00-9 4-(4-chlorophenyl)-3,6-dimethoxypyridazine 
• 1190764-77-2 (3,6-dimethoxy-pyridazin-4-ylmethyl)-carbamic acid benzyl ester 
• 1072855-18-5 (3S)-N,N-dibenzyl-5-(3,6-dimethoxypyridazin-4-yl)chroman-3-amine 
• 1673-34-3 3,6-dimethoxy-4-nitro-pyridazine 1-oxide 
• 98334-82-8 3,4,6-Trimethoxy-pyridazin 
• 1075-68-9 3,6-Dimethoxy-4-aminopyridazin 

Relevant articles and documents

N -Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism

An unprecedented N -chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic analysis, the assisting role of n -Bu 4NCl as an exogenous nucleophile was identified, and the optimized reaction conditions were applied to a range of 1,4-dimethoxyphthalazine derivatives. Also, an improvement of overall efficiency was demonstrated by the use of a labile O -silyl group. A bicyclization/ring-opening mechanism, inspired by the Favorskii rearrangement, was proposed and supported by the DFT calculations. Furthermore, the efforts on scope expansion as well as the evaluation of other electrophilic promoters revealed that the newly developed ring contraction reactivity is a unique characteristic of 1,4-dimethoxyphthalazine scaffold and TCICA.

CINNOLINE COMPOUNDS, THEIR PREPARATION, AND THEIR USE

The present invention relates to cinnoline compounds, particularly 4-amino-N-cyclopropyl- 7-fluoro-8-(3,6-dimethoxypyridazin-4-yl)cinnoline-3-carboxamide and salts thereof. The claimed invention also relates to compositions comprising such a compound, as

Compounds and Uses Thereof - 848

This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof, wherein R1, R2, Rsu