496-46-8Relevant articles and documents
Understanding behaviour of vitamin-C guest binding with the cucurbit[6]uril host
Pandey, Shubham,Soni, Vineet Kumar,Choudhary, Ganpat,Sharma, Pragati R.,Sharma, Rakesh K.
, p. 387 - 394 (2017)
The present study describes non-covalent interaction and complexation behaviour of sodium ascorbate (SA) with cucurbit[6]uril (CB[6]) at neutral pH in aqueous Na2SO4 solution. The interaction behaviour is investigated using various analytical techniques like NMR, UV–Vis, fluorescence, TGA and DRS. The substantial increase in the intensity of emission and absorption spectra of sodium ascorbate is observed. The Benesi–Hildebrand evaluation method is used to determine the stoichiometry and equilibrium constant of the cucurbit[6]uril–sodium ascorbate complex, which suggested the 1:1 complex. Time-dependent 1H NMR, 13C CP MAS and CD studies also echoed non-covalent interaction between SA with CB[6].
Efficient method for the cycloaminomethylation of glycoluril
Wingard, Leah A.,Johnson, Eric C.,Sabatini, Jesse J.
, p. 1681 - 1682 (2016)
The efficient method for the cycloaminomethylation of glycoluril to yield 2,6-ditert-butylhexahydro-1H,5H-2,3a,4a,6,7a,8a-hexaazacyclopenta[def]fluorene-4,8-dione is described. The material is synthesized employing water as the solvent, and is isolated by filtration. This is an improvement over the previous reported synthetic method, which relied on the use of samarium trichloride catalysis, as well as silica gel column chromatographic purification to obtain the target product.
Critical Parameters for Green Glycoluril Synthesis
Araki, K.,Bertolucci, M. M.,Demets, G. J. F.,Oliveira, A. de,Soares, R. S. B.,Souza, L. R. R.
, p. 739 - 742 (2021/06/02)
Abstract: We have studied the critical parameters of Micheletti’s glycoluril synthesisstarting from urea and glyoxal on a statistical and multivariate analysis basis[12]. The process ispotentially highly useful for scaling-up glycoluril production, and needs to beoptimized. We have come to a conclusion thatH3PO4 could be used as well asP4O10 giving high yields attemperature around 95°C, using glyoxal without prior purification. All reactionshave been completed in less than 25 min with the yield as high as 80% under theoptimized conditions.
Synthesis of Glycoluril using Urea Phosphate
Karpagalakshmi, K.,Lakshminarayanan, P.,Prakash, R.,Ramalakshmi, S.,Selvapalam, N.,Usha, G.,Yang, C.
, p. 1988 - 1992 (2022/01/24)
Abstract: Glycolurils are building blocks for the synthesis of cucurbiturils that are important host materials for several applications. Glycolurils are prepared conveniently by the condensation of 1,2-diketones with urea using an acid as catalyst. Herein, we report a facile method of synthesis of various glycolurils using urea phosphate and 1,2-diketones.
Dual-Stimuli Responsive 2D Supramolecular Organic Framework for the Detection of Azoreductase Activity
Zhang, Hao,Liang, Feng,Yang, Ying-Wei
supporting information, p. 198 - 205 (2019/12/12)
A 2D supramolecular organic framework (SOF) based on synthetic macrocycles has been constructed in water by a self-assembly strategy. Two new organic monomers of this SOF, possessing viologen and azobenzene functional groups, form a stimuli-responsive host–guest system upon cooperatively binding with cucurbit[8]uril rings. The reversible formation and dissociation of 2D SOF can be realized by the isomerization of azobenzene under ultraviolet and visible light. The light-responsive property of the SOF is highly reversible and stable for up to four cycles. Moreover, azoreductase produced by Escherichia coli can reduce the N=N double bond of azobenzene entities, resulting in fluorescence recovery of the system. As an excellent and effective fluorescent probe, the SOF can detect azoreductase activity for real-time monitoring of the growth process of Escherichia coli. The dual-stimuli responsive 2D SOF is envisioned to drive the development of responsive devices with complex functions.
