52022-77-2 Usage
Description
3-Nitrophenethyl alcohol, also known as 3-NPEA, is an organic compound with the chemical formula C8H9NO3. It is a colorless to pale yellow liquid with a characteristic odor. 3-NITROPHENETHYL ALCOHOL is characterized by the presence of a nitro group (-NO2) attached to a phenethyl alcohol backbone, which contributes to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
3-Nitrophenethyl alcohol is used as a substrate for the engineering of nitrobenzene dioxygenase, an enzyme that plays a crucial role in the production of hydroxytyrosol. Hydroxytyrosol is a highly potent antioxidant known for its various health benefits, including its antioxidant, anti-inflammatory, and neuroprotective properties. The use of 3-NPEA in this process aids in the development of novel and efficient methods for synthesizing hydroxytyrosol, which can be utilized in the pharmaceutical industry for the treatment and prevention of various diseases and conditions.
Used in Chemical Synthesis:
3-Nitrophenethyl alcohol can also be used as a versatile intermediate in the synthesis of various organic compounds, particularly those with pharmaceutical or chemical applications. Its unique structure allows for a range of chemical reactions, such as reduction, substitution, and condensation, which can lead to the formation of a diverse array of products. This makes 3-NPEA a valuable building block in the development of new drugs, agrochemicals, and other specialty chemicals.
Used in Research and Development:
Due to its unique chemical properties and reactivity, 3-nitrophenethyl alcohol is often employed in research and development settings. It can be used as a model compound to study various chemical reactions and mechanisms, as well as to develop new synthetic methods and techniques. Additionally, its use in the engineering of nitrobenzene dioxygenase for the production of hydroxytyrosol can provide valuable insights into enzyme catalysis and the development of biocatalytic processes for the synthesis of valuable compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 52022-77-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,2 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 52022-77:
(7*5)+(6*2)+(5*0)+(4*2)+(3*2)+(2*7)+(1*7)=82
82 % 10 = 2
So 52022-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO3/c1-6(10)7-3-2-4-8(5-7)9(11)12/h2-6,10H,1H3
52022-77-2Relevant articles and documents
CHEMICAL COMPOUNDS
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Page/Page column 177, (2019/04/11)
The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to FormμLa (I): wherein R, R1,P, X, Y, and Z are as defined herein; or a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of CD73 and can be usefμL in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, the treatment of HIV, autoimmune diseases, infections, atherosclerosis, and ischemia–reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety
Xie, Jin,Yang, Fengzhi,Zhang, Man,Lam, Celine,Qiao, Yixue,Xiao, Jia,Zhang, Dongdong,Ge, Yuxuan,Fu, Lei,Xie, Dongsheng
, p. 131 - 134 (2016/12/27)
A series of CAPE derivatives with mono-substituted phenylethanols moiety were synthesized and evaluated by MTT assay on growth of 4 human cancer cell lines (Hela, DU-145, MCF-7 and ECA-109). The substituent effects on the antiproliferative activity were systematically investigated for the first time. It was found that electron-donating and hydrophobic substituents at 2′-position of phenylethanol moiety could significantly enhance CAPE's antiproliferative activity. 2′-Propoxyl derivative, as a novel caffeic acid ester, exhibited exquisite potency (IC50?=?0.4?±?0.02 & 0.6?±?0.03?μM against Hela and DU-145 respectively).
QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS
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Page/Page column 78, (2016/12/16)
Compounds of formula (I) that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.