5373-87-5

Basic information

• Product Name: N'-Hydroxy-4-methoxybenzenecarboximidamide
• Synonyms: 4-methoxybenzamidoxime;anisamidoxime;n-hydroxy-4-methoxy-benzenecarboximidamid;p-anisamidoxime;p-methoxybenzamideoxime;N-HYDROXY-4-METHOXY-BENZAMIDINE;N'-HYDROXY-4-METHOXYBENZENECARBOXIMIDAMIDE;N'-Hydroxy-4-methoxybenzenecarboximideamide
• CAS NO: 5373-87-5
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Product Categories: pharmacetical
• Mol File: 5373-87-5.mol
• Article Data: 110

Chemical Properties

• Melting Point: 122-128°C
• Boiling Point: 344.8 °C at 760 mmHg
• Flash Point: 162.3 °C
• Appearance: /
• Density: 1.21 g/cm³
• CAS DataBase Reference: N'-Hydroxy-4-methoxybenzenecarboximidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-Hydroxy-4-methoxybenzenecarboximidamide(5373-87-5)
• EPA Substance Registry System: N'-Hydroxy-4-methoxybenzenecarboximidamide(5373-87-5)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• RTECS: BZ3425000
• HazardClass: IRRITANT
• Hazardous Substances Data: 5373-87-5(Hazardous Substances Data)

Usage

General Description

N'-Hydroxy-4-methoxybenzenecarboximidamide, also known as 4-Methoxybenzohydroxamic acid, is a chemical compound with the molecular formula C8H9NO3. It is a derivative of hydroxamic acid, which is known for its ability to chelate metal ions. N'-Hydroxy-4-methoxybenzenecarboximidamide has been studied for its potential applications in various fields, including medicine, biochemistry, and environmental science. It exhibits strong metal chelating properties, making it useful in metal ion removal and purification processes. Additionally, it has shown potential as an anticancer agent, as well as in the treatment of neurological disorders. Further research is ongoing to explore its potential uses and applications.

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 67-56-1 methanol 
• 68451-74-1 C₁₅H₁₄N₂O₃ 
• 68451-88-7 C₁₅H₁₃ClN₂O₃ 
• 68451-81-0 C₁₆H₁₆N₂O₄ 
• 68451-94-5 (Z)-4-methoxy-N'-((4-nitrobenzoyl)oxy)benzimidamide 
• 125338-26-3 (3aR,9aR)-3,8-Bis-(4-methoxy-phenyl)-3a,9a-dihydro-5aH-isoxazolo[4,5-e][1,2,4]oxadiazolo[4,5-a]pyridine 
• 124-41-4 sodium methylate 
• 125324-42-7 8-(4-Methoxy-phenyl)-3-phenyl-3a,9a-dihydro-5aH-isoxazolo[4,5-e][1,2,4]oxadiazolo[4,5-a]pyridine 
• 125324-40-5 3-(4-Methoxy-phenyl)-5-{(E)-2-[3-(4-methoxy-phenyl)-isoxazol-4-yl]-vinyl}-4,5-dihydro-[1,2,4]oxadiazole 
• 123-11-5 4-methoxy-benzaldehyde 
• 3717-21-3 p-methoxyl benzaldoxime 
• 860584-94-7 (+/-)-4-(chloro-nitroso-methyl)-anisole 
• 3717-21-3 (E)-4-methoxybenzaldoxime 

Downstream Products

• 94192-18-4 3-<(3-p-Anisyl)-1,2,4-oxadiazol-5-yl>propionic acid 
• 949-02-0 N-acetoxy-4-methoxy-benzamidine 
• 73217-70-6 5-dichloromethyl-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 58589-03-0 5-(2-aminophenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 16013-13-1 3-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 95373-36-7 N-(3-chloro-propionyloxy)-4-methoxy-benzamidine 
• 81467-51-8 C₁₂H₁₄N₂O₄ 
• 129137-63-9 N-Mesitoyl-4-methoxybenzamidoxime 
• 129137-62-8 O-Mesitoyl-4-methoxybenzamidoxime 
• 874-90-8 4-methoxybenzonitrile 
• 75273-66-4 3-(4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole 
• 259150-99-7 3-(4-methoxy-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid methyl ester 

Relevant articles and documents

1,2,4-Triazolium ions as flexible scaffolds for the construction of polyphilic ionic liquid crystals

A novel scaffold for the construction of self-organised ionic liquids and ionic liquid crystals bearing both perfluorocarbon and hydrocarbon moieties has been developed. The phase behaviour and physical properties of these materials can be tuned as a function of chain length and fluorine content and significant structural elaboration is possible, giving a highly flexible system.

Oxadiazol-based mTOR inhibitors with potent antiproliferative activities: synthetic and computational modeling

Series of N-aryl-1,3,4-oxadiazole-2-amines and 3-aryl-1,2,4-oxadiazole-5-carboxamides derivatives were synthesized as novel chemotherapeutic agents. Synthesized compounds were evaluated for their anticancer activities against several cancer cell lines. Many analogues of 1,3,4-oxadiazole scaffold showed potent antiproliferative activities against breast cancer cell lines, with higher activities toward the metastatic breast cancer cell line (MDA-MB-231). Active analogues were profiled using in-house pharmacophore database in search for molecular target. Active analogues (2j and 2k) were found to fit the pharmacophoric map of ATP-competitive inhibitors of mTOR. The mTOR inhibitory activities of the most active compounds were confirmed with IC50 values in nanomolar range. The N-aryl-1,3,4-oxadiazole-2-amines linked to a basic head is a novel ATP-competitive inhibitors of mTOR with potential activities for treatment of different types of cancer. Graphical abstract: [Figure not available: see fulltext.].

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.