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Cas Database

5619-07-8

5619-07-8

Identification

  • Product Name:Phenylalanine, methylester, hydrochloride (1:1)

  • CAS Number: 5619-07-8

  • EINECS:227-049-2

  • Molecular Weight:215.68

  • Molecular Formula: C10H14ClNO2

  • HS Code:

  • Mol File:5619-07-8.mol

Synonyms:Alanine,phenyl-, methyl ester, hydrochloride, DL- (8CI);DL-Phenylalanine, methylester, hydrochloride;Phenylalanine, methyl ester, hydrochloride (9CI);(?à)-Phenylalanine methyl esterhydrochloride;

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Safety information and MSDS view more

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:DL-Phenylalanine methyl ester hydrochloride
  • Packaging:25g
  • Price:$ 396
  • Delivery:In stock
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  • Manufacture/Brand:Usbiological
  • Product Description:DL-Phenylalanine methyl ester hydrochloride
  • Packaging:5g
  • Price:$ 170
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:DL-phenylalaninemethylesterhydrochloride
  • Packaging:250mg
  • Price:$ 50
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:H-DL-Phe-OMe.HCl 98%
  • Packaging:100g
  • Price:$ 112
  • Delivery:In stock
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  • Manufacture/Brand:Chem-Impex
  • Product Description:DL-Phenylalaninemethylesterhydrochloride,99%(HPLC) 99%(HPLC)
  • Packaging:25G
  • Price:$ 75.38
  • Delivery:In stock
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  • Manufacture/Brand:Chem-Impex
  • Product Description:DL-Phenylalaninemethylesterhydrochloride,99%(HPLC) 99%(HPLC)
  • Packaging:100G
  • Price:$ 243.04
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  • Manufacture/Brand:Chem-Impex
  • Product Description:DL-Phenylalaninemethylesterhydrochloride,99%(HPLC) 99%(HPLC)
  • Packaging:250G
  • Price:$ 405.44
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  • Manufacture/Brand:Chem-Impex
  • Product Description:DL-Phenylalaninemethylesterhydrochloride,99%(HPLC) 99%(HPLC)
  • Packaging:5G
  • Price:$ 23.18
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:METHYL 2-AMINO-3-PHENYLPROPANOATE HYDROCHLORIDE 95.00%
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:METHYL 2-AMINO-3-PHENYLPROPANOATE HYDROCHLORIDE 95.00%
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Relevant articles and documentsAll total 33 Articles be found

Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides

Khalesi, Maryam,Halimehjani, Azim Ziyaei,Martens, Jürgen

, p. 852 - 857 (2019)

The synthesis of a novel category of pseudo-peptides via intramolecular Ugi reaction of levulinic acid (4-oxopentanoic acid), aromatic and aliphatic amines, and amino acid-based isocyanides is reported. Levulinic acid was applied as a bifunctional substrate containing both carbonyl and acid moieties suitable for the Ugi reaction. This article provides a facile and convenient one-pot procedure for the synthesis of peptide-like heterocyclic molecules containing 2-pyrrolidone (γ-lactam), amide and ester functional groups with good to excellent yields.

Transition Metal-Free N-Arylation of Amino Acid Esters with Diaryliodonium Salts

Kervefors, Gabriella,Kersting, Leonard,Olofsson, Berit

supporting information, p. 5790 - 5795 (2021/03/08)

A transition metal-free approach for the N-arylation of amino acid derivatives has been developed. Key to this method is the use of unsymmetric diaryliodonium salts with anisyl ligands, which proved important to obtain high chemoselectivity and yields. The scope includes the transfer of both electron deficient, electron rich and sterically hindered aryl groups with a variety of different functional groups. Furthermore, a cyclic diaryliodonium salt was successfully employed in the arylation. The N-arylated products were obtained with retained enantiomeric excess.

Chiral polycyclic tropane compound as well as preparation method and application thereof

-

Paragraph 0110-0113, (2021/08/25)

The invention provides a chiral polycyclic tropane compound as well as a preparation method and application thereof. The invention specifically relates to a tropane compound shown as a formula I, or a salt thereof, or a stereoisomer thereof, or a crystal form thereof, and a preparation method and application thereof. The preparation method disclosed by the invention is simple in process, mild in reaction condition and high in yield, and the obtained product has excellent enantioselectivity and diastereoselectivity. Experiments prove that the tropane compound can effectively inhibit various tumor cells, especially lung cancer cells, melanoma cells, breast cancer cells, in-situ pancreatic cancer cells and pancreatic cancer cells, so that the compound has a wide prospect in preparation of drugs for preventing and/or treating tumors.

Synthesis and Penicillin-binding Protein Inhibitory Assessment of Dipeptidic 4-Phenyl-β-lactams from α-Amino Acid-derived Imines

Decuyper, Lena,Juki?, Marko,Sosi?, Izidor,Amoroso, Ana Maria,Verlaine, Olivier,Joris, Bernard,Gobec, Stanislav,D'hooghe, Matthias

supporting information, p. 51 - 55 (2019/11/28)

Monocyclic β-lactams revive the research field on antibiotics, which are threatened by the emergence of resistant bacteria. A six-step synthetic route was developed, providing easy access to new 3-amino-1-carboxymethyl-4-phenyl-β-lactams, of which the penicillin-binding protein (PBP) inhibitory potency was demonstrated biochemically.

Bioinspired Radical Stetter Reaction: Radical Umpolung Enabled by Ion-Pair Photocatalysis

Morack, Tobias,Mück-Lichtenfeld, Christian,Gilmour, Ryan

supporting information, p. 1208 - 1212 (2019/01/04)

A bioinspired, intermolecular radical Stetter reaction of α-keto acids and aldehydes is disclosed that is contingent on a formal “radical umpolung” concept. Enabled by secondary amine activation, electrostatic recognition ensures that the α-ketocarboxylic acids, which function as latent acyl radicals, are proximal to the in situ generated iminium salts. This photoactive contact ion pair is an electron donor–acceptor (EDA) complex, and undergoes facile single electron transfer (SET) and rapid decarboxylation prior to radical–radical recombination. Importantly, decarbonylation is mitigated by this strategy. The initial computational validation on which the process is predicated matches closely with experiment. Synergising organo- and photocatalysis activation principles finally expands the mechanistic and synthetic scope of the classic Stetter reaction to include α,β-unsaturated aldehydes as acceptors.

Process route upstream and downstream products

Process route

PChd-Phe-OMe
90315-76-7

PChd-Phe-OMe

2,6-di(t-butyl)-4-phenylphenol
2668-47-5

2,6-di(t-butyl)-4-phenylphenol

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In methanol; electrolysis;
90%
methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
With thionyl chloride; In methanol; at 20 ℃;
93.61%
methanol
67-56-1

methanol

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
With thionyl chloride; at 5 - 50 ℃; for 25h;
100%
With thionyl chloride; at 50 ℃; for 25h; Cooling with ice;
100%
With thionyl chloride; at 0 - 20 ℃; for 20h;
99%
With chloro-trimethyl-silane; at 20 ℃; for 12h;
96%
With thionyl chloride; for 5h; Heating;
94%
With thionyl chloride; for 14h; Reflux; Cooling with ice;
90%
With thionyl chloride; for 14h; Inert atmosphere; Schlenk technique; Cooling with ice; Reflux;
90%
With thionyl chloride; for 15h; Heating;
With acetyl chloride; at 20 ℃;
With thionyl chloride; for 12h; Heating;
With thionyl chloride;
With sulfuryl dichloride; at 0 ℃;
With hydrogenchloride;
With thionyl chloride; at 20 ℃;
With thionyl chloride; at 78 ℃;
With thionyl chloride; at 0 ℃; Reflux;
With thionyl chloride; at 0 ℃;
With thionyl chloride; Reflux;
With thionyl chloride; at 20 ℃; for 2h; Inert atmosphere;
With thionyl chloride; at 0 ℃; Reflux;
With thionyl chloride; at 0 - 20 ℃;
With thionyl chloride; at 0 ℃; for 1h; Inert atmosphere; Reflux;
11.8g
With thionyl chloride; at 0 - 20 ℃; for 17h; Inert atmosphere;
With thionyl chloride; for 25h;
With thionyl chloride; at 0 ℃; for 1h; Reflux;
With thionyl chloride; for 3h; Reflux;
2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In water; at 20 ℃; for 18h;
99%
β-chloro-β-phenylalanine methyl ester hydrochloride
100020-81-3

β-chloro-β-phenylalanine methyl ester hydrochloride

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In methanol; for 6h; Ambient temperature;
87%
methyl 2-(N,N-dibenzylamino)-3-phenylpropanoate
112302-89-3

methyl 2-(N,N-dibenzylamino)-3-phenylpropanoate

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
With formic acid; palladium; In methanol; for 2h; Ambient temperature;
90%
methanol
67-56-1

methanol

phenylalanine methyl ester hydrochloride
27172-85-6

phenylalanine methyl ester hydrochloride

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In water; for 1h; Reflux;
Phenylserin
69-96-5

Phenylserin

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: SOCl2 / 4 h
2: SOCl2 / 10 h / Heating
3: 87 percent / H2 / 10percent Pd/C / methanol / 6 h / Ambient temperature
With thionyl chloride; hydrogen; palladium on activated charcoal; In methanol;
benzaldehyde
100-52-7

benzaldehyde

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: 74.8 percent / NaOH / methanol; H2O / 1.) 16 dg C, 30 min; 2.) RT, overnight
2: SOCl2 / 4 h
3: SOCl2 / 10 h / Heating
4: 87 percent / H2 / 10percent Pd/C / methanol / 6 h / Ambient temperature
With sodium hydroxide; thionyl chloride; hydrogen; palladium on activated charcoal; In methanol; water;
β-chloro-β-phenylalanine
229485-67-0

β-chloro-β-phenylalanine

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: SOCl2 / 10 h / Heating
2: 87 percent / H2 / 10percent Pd/C / methanol / 6 h / Ambient temperature
With thionyl chloride; hydrogen; palladium on activated charcoal; In methanol;

Global suppliers and manufacturers

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  • Amadis Chemical Co., Ltd.
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  • Shaanxi BLOOM TECH Co.,Ltd
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  • Win-Win chemical Co.Ltd
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  • Kono Chem Co.,Ltd
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  • Shanghai Apeptide Co., Ltd.
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  • GL Biochem (Shanghai) Ltd.
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  • Finetech Industry Limited
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  • Boc Sciences
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