5680-80-8

Basic information

• Product Name: L-Serine methyl ester hydrochloride
• Synonyms: L-SERINE METHYL ESTER HYDROCHLORIDE, 99+%;L-SerineMethylEsterHydrochloride>98%;L-Ser-OMe.HCl;L-SERINEMETHYLESTERHCL(L-SER-OMEHCL);serine methyl ester;(S)-Serine Methyl Ester Hydrochloride;L-SERINE METHYL ESTER HYDROCHLORIDE extrapure;Methyl (2R)-2-amino-3-hydroxypropanoate hydrochloride
• CAS NO: 5680-80-8
• Molecular Formula: C₄H₁₀NO₃*Cl
• Molecular Weight: 155.58
• EINECS: 227-140-7
• Product Categories: Protected Amino Acids;AMINOACIDS DERIVATIVES;Amino Acid Derivatives;Amino Acids;Amino Acids and Derivatives;Amino Acids 13C, 2H, 15N;Amino Acid Methyl Esters;Amino Acids (C-Protected);Biochemistry;Amino hydrochloride;Amino Acids & Derivatives;Amino Acid Derivatives;Peptide Synthesis;Serine;amino;Amino acid
• Mol File: 5680-80-8.mol

Chemical Properties

• Melting Point: 163 °C (dec.)(lit.)
• Boiling Point: 234.7 °C at 760 mmHg
• Flash Point: 95.8 °C
• Appearance: White to off-white/Crystalline Powder or Crystals
• Vapor Pressure: 0.00953mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: DMSO (Sparingly), Methanol (Slightly), Water (Slightly)
• PKA: pK1:7.03(+1) (25°C,μ=0.1)
• Water Solubility: soluble
• Sensitive: Moisture Sensitive
• BRN: 3559591
• CAS DataBase Reference: L-Serine methyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Serine methyl ester hydrochloride(5680-80-8)
• EPA Substance Registry System: L-Serine methyl ester hydrochloride(5680-80-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• F: 3-10-21
• Hazardous Substances Data: 5680-80-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
L-Serine methyl ester hydrochloride is used as a synthetic intermediate for the preparation of various organic compounds. Its reactivity and functional groups make it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
In the Pharmaceutical Industry:
L-Serine methyl ester hydrochloride is used as a key component in the synthesis of certain pharmaceuticals. Its ability to form esters and participate in various chemical reactions allows for the creation of new drug candidates with potential therapeutic applications.
In the Agrochemical Industry:
L-Serine methyl ester hydrochloride is utilized in the development of agrochemicals, such as pesticides and herbicides. Its involvement in organic synthesis enables the production of compounds that can help protect crops and enhance agricultural productivity.
In the Specialty Chemicals Industry:
L-Serine methyl ester hydrochloride is employed in the synthesis of specialty chemicals, which are used in a wide range of applications, including cosmetics, fragrances, and dyes. Its unique properties allow for the creation of novel compounds with specific functionalities and improved performance.

InChI:InChI=1/C4H9NO3/c1-8-4(7)3(5)2-6/h3,6H,2,5H2,1H3/p+1/t3-/m0/s1

Upstream product

• 111934-17-9 (S)-2-(2-Aza-bicyclo[2.2.1]hept-5-en-2-yl)-3-hydroxy-propionic acid methyl ester 
• 58861-77-1 4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 67-56-1 methanol 
• 16428-75-4 D,L-serine hydrochloride 
• 56-45-1 L-serin 
• 96854-24-9 (S)-N-(Methoxycarbonyl)serine Methyl Ester 
• 75-44-5 phosgene 
• 312-84-5 D-Serine 
• 1258511-48-6 tert-butyl 1-({[(1S)-1-(hydroxymethyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-(1S,4R)-7-azabicyclo[2.2.1]hept-2-ene-7-carboxylic acid 
• 1258511-47-5 tert-butyl 1-({[(1S)-1-(hydroxymethyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-(1R,4S)-7-azabicyclo[2.2.1]hept-2-ene-7-carboxylic acid 
• 75-36-5 acetyl chloride 
• 13165-72-5 chlorosulfite de methyle 

Downstream Products

• 20989-43-9 Bz-Gly-Ser-OMe 
• 19542-34-8 N-(benzyloxycarbonyl)-L-alanyl-L-serine methyl ester 
• 6225-27-0 N-(N-Benzloxycarbonyl-D-seryl)-L-serin-methylester 
• 5874-76-0 N-(N-benzyloxycarbonyl-L-seryl)-L-serine methyl ester 
• 32668-18-1 Z-Gln-Ser-OMe 
• 51871-02-4 Z-Asp(OBzl)-Ser-OMe 
• 15364-45-1 N-(N-benzyloxycarbonyl-L-tyrosyl)-L-serine methyl ester 
• 58202-81-6 (S)-2-((S)-1-benzyloxycarbonylamino-ethyl)-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 2488-24-6 N-Benzyloxycarbonyl-L-threonyl-L-serin-methylester 
• 17896-46-7 N-(p-Methoxybenzyloxycarbonyl)-L-threonin-L-serin-methylester 
• 105667-32-1 -(L-serin-methylester) 
• 791729-81-2 2-Chloralaninmethylester 
• 13515-76-9 methyl N-trityl-L-serinate 
• 2608-06-2 N-(2-nitro-benzenesulfenyl)-L-serine methyl ester 

Relevant articles and documents

Synthesis and Biological Evaluation of a Series of Novel Celastrol Derivatives with Amino Acid Chain

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The invention belongs to the field of chemical synthesis, and particularly relates to a production technology of cycloserine. According to the synthesis technology, D-serine is used as a starting material, three reactions of esterification, chlorination and cyclization are performed, and the cycloserine is obtained. The technological process is simple, the yield is high, and the purity is high. During the esterification reaction, diethyl ether is replaced with ethyl acetate, no 8-hydroxyquinoline is added for crude product preparation after the cyclization reaction, and usage of reagent diethyl ether likely to produce toxicity and the dangerous product 8-hydroxyquinoline is avoided. Meanwhile, the synthesis route is short, the cost is low, and the obtained product is stable in yield and controllable in quality.

DIPEPTIDE AND TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS

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PYRIMIDINE NUCLEOSIDE DERIVATIVES, SYNTHESIS METHODS AND USES THEREOF FOR PREPARING ANTI-TUMOR AND ANTI-VIRUS MEDICAMENTS

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Concise synthesis of (+)-serinolamide A

Serinolamide A, isolated from a species of marine cyanobacteria, exhibits a moderate agonist effect and selectivity for the CB1 cannabinoid receptor, which is unusual for marine natural products. Herein, we reported a highly efficient enantiospecific first total synthesis of (+)-serinolamide A from l-serine in nine steps with 30% overall yield. The synthesis method provides a facile, practicable, and economical approach for the preparation of other similar endocanabinoid lipids.

Telomestatin: Formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes

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Expanded scope for the iridium-catalyzed asymmetric isomerization of primary allylic alcohols using readily accessible second-generation catalysts

A second generation of chiral (P,N)-iridium catalysts - readily accessible from inexpensive l-serine - displays expanded scope for the asymmetric isomerization of primary allylic alcohols.

METHODS FOR INDUCING THE DIFFERENTIATION OF HEMATOPOIETIC STEM CELLS INTO MEGAKARYOCYTES AND PLATELETS, AND GENE CONTROLLING THE DIFFERENTIATION

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