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Cas Database

58-93-5

58-93-5

Identification

  • Product Name:Hydrochlorothiazide

  • CAS Number: 58-93-5

  • EINECS:200-403-3

  • Molecular Weight:297.743

  • Molecular Formula: C7H8ClN3O4S2

  • HS Code:29350090

  • Mol File:58-93-5.mol

Synonyms:3,4-Dihydrochlorothiazide;Prestwick_263;6-Chloro-7-sulfamoyl-3, 4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide;Maschitt;Newtolide;3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothiadiazine-1,1-dioxide;component of Esimil;Dihydrochlorothiazid;Idrotiazide;Hydril;Drenol;Hydrochlorothiazid;Thiuretic;Hidrotiazida;Hydro-Diuril;Hydro-Aquil;Megadiuril;HCTZ;Aquarius;Component of Aldoril;2H-1,2,4-Benzothiadiazine-7-sulfonamide,6- chloro-3,4-dihydro-,1,1-dioxide;6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;Jen-Diril;Hidrochlortiazid;Esidrex;Disalunil;

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Safety information and MSDS view more

  • Pictogram(s):FlammableF, ToxicT, IrritantXi

  • Hazard Codes:Xi,T,F,Xn

  • Signal Word:Danger

  • Hazard Statement:H302 Harmful if swallowedH317 May cause an allergic skin reaction H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. SYMPTOMS: Acute symptoms may include dryness of the mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. May also cause hypersensitivity reactions, skin and mucous membrane irritation. Long term effects may include adverse hematologic reactions including aplastic anemia. ACUTE/CHRONIC HAZARDS: This compound may cause skin and mucous membrane irritation. Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

  • Fire-fighting measures: Suitable extinguishing media Fires involving this compound should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. Flash point data for this chemical are not available but it is probably combustible. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Should a spill occur while you are handling this chemical, you should dampen the solid spill material with acetone, then transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor tight plastic bag for eventual disposal. solvent wash all contaminated surfaces with acetone followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the safety officer (or other responsible person) has verified that the area has been properly cleaned

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Hydrochlorothiazide tablets and oral solution should be stored in well closed containers at a temperature less than 40°C, preferably at 15 to 30°C. Freezing of the oral solution should be avoided.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
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  • Manufacture/Brand:Usbiological
  • Product Description:Hydrochlorothiazide
  • Packaging:10g
  • Price:$ 337
  • Delivery:In stock
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  • Manufacture/Brand:Usbiological
  • Product Description:Hydrochlorothiazide
  • Packaging:10g
  • Price:$ 312
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  • Manufacture/Brand:TRC
  • Product Description:Hydrochlorothiazide
  • Packaging:250g
  • Price:$ 525
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Hydrochlorothiazide
  • Packaging:25 g
  • Price:$ 104
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Hydrochlorothiazide
  • Packaging:100 g
  • Price:$ 208
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Hydrochlorothiazide
  • Packaging:500 g
  • Price:$ 720
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Hydrochlorothiazide United States Pharmacopeia (USP) Reference Standard
  • Packaging:200mg
  • Price:$ 366
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Hydrochlorothiazide European Pharmacopoeia (EP) Reference Standard
  • Packaging:
  • Price:$ 190
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Hydrochlorothiazide for peak identification European Pharmacopoeia (EP) Reference Standard
  • Packaging:
  • Price:$ 190
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Hydrochlorothiazide for peak identification European Pharmacopoeia (EP) Reference Standard
  • Packaging:y0001494
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Relevant articles and documentsAll total 11 Articles be found

Different approaches in Partial Least Squares and Artificial Neural Network models applied for the analysis of a ternary mixture of Amlodipine, Valsartan and Hydrochlorothiazide

Darwish, Hany W.,Hassan, Said A.,Salem, Maissa Y.,El-Zeany, Badr A.

, p. 744 - 750 (2014)

Different chemometric models were applied for the quantitative analysis of Amlodipine (AML), Valsartan (VAL) and Hydrochlorothiazide (HCT) in ternary mixture, namely, Partial Least Squares (PLS) as traditional chemometric model and Artificial Neural Networks (ANN) as advanced model. PLS and ANN were applied with and without variable selection procedure (Genetic Algorithm GA) and data compression procedure (Principal Component Analysis PCA). The chemometric methods applied are PLS-1, GA-PLS, ANN, GA-ANN and PCA-ANN. The methods were used for the quantitative analysis of the drugs in raw materials and pharmaceutical dosage form via handling the UV spectral data. A 3-factor 5-level experimental design was established resulting in 25 mixtures containing different ratios of the drugs. Fifteen mixtures were used as a calibration set and the other ten mixtures were used as validation set to validate the prediction ability of the suggested methods. The validity of the proposed methods was assessed using the standard addition technique.

Metal-free oxidative cyclization of 2-amino-benzamides, 2-aminobenzenesulfonamide or 2-(aminomethyl)anilines with primary alcohols for the synthesis of quinazolinones and their analogues

Sun, Jinwei,Tao, Tao,Xu, Dan,Cao, Hui,Kong, Qinggang,Wang, Xinyu,Liu, Yun,Zhao, Jianglin,Wang, Yi,Pan, Yi

, p. 2099 - 2102 (2018/05/04)

A general metal-free oxidative cyclization process has been developed for the synthesis of quinazolinones, benzothiadiazines and quinazolines. By this protocol, a range of substituted 2-aminobenzamides, 2-aminobenzenesulfonamide and 2-(aminomethyl)anilines react with various alcohols, leading to the desired annulated products smoothly. This protocol features many advantages as broad substrate scope, mild reaction conditions, low environmental pollution, high atom-economy and good to excellent yields.

A method for production of hydrogen chlorothiazide

-

Paragraph 0027-0030, (2017/03/08)

The invention belongs to the technical field of medicine production, and particularly relates to a production method for hydrochlorothiazide. Hydrochlorothiazide is prepared by using 4-amino-6-chloro-1,3-benzenedisulfonamide and formaldehyde as raw materials, reacting for 0.5-1.5 hours at a temperature of 90-100 DEG C; cooling a reaction liquid, de-coloring and adjusting a pH value to 5.5-7.0, and carrying out separation and purification. The production method is simple in process and suitable for industrialized production. The whole process is carried out in an aqueous phase; reaction conditions are mild; security coefficient is greatly increased; production period is short and is largely controlled at about 50 hours; the whole production process has small pollution to the environment; and the purity of the synthetic hydrochlorothiazide is high.

Process route upstream and downstream products

Process route

chlorothiazide
58-94-6

chlorothiazide

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield
With potassium borohydride; acetic acid; In methanol; at -10 - 5 ℃; for 4h; Reagent/catalyst; Solvent;
93.9%
With hydrogen; platinum(IV) oxide; In ethanol;
chloraminophenamide
121-30-2

chloraminophenamide

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield
In water; Reflux;
92%
In ethanol; at 90 ℃; for 384h;
8.36%
With hydrogenchloride; ethyl acetate;
With hydrogenchloride; In ethanol;
With ammonium chloride; In water; for 1.5h; Heating;
In methanol; water; for 1h; Heating;
With ammonium hydroxide; Heating;
With sulfuric acid; In methanol; at 20 - 30 ℃; for 9h; Product distribution / selectivity; Heating / reflux;
With hydrogenchloride; In ethanol; at 20 - 30 ℃; for 9h; Product distribution / selectivity; Heating / reflux;
With hydrogenchloride; In methanol; at 20 - 30 ℃; for 9h; Product distribution / selectivity; Heating / reflux;
In water; at 80 - 100 ℃; for 2.5h; Temperature;
In water; at 100 ℃; for 0.2h;
With Yb3+ -exchanged montmorillonite; In water; at 60 ℃; for 1h;
> 99 %Spectr.
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
88150-42-9

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4,137862-87-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield
chloraminophenamide
121-30-2

chloraminophenamide

methanol
67-56-1

methanol

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield
With tert.-butylhydroperoxide; at 110 ℃; for 12h;
63%
C<sub>20</sub>H<sub>25</sub>NO<sub>5</sub>
68905-61-3

C20H25NO5

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield
With water; at 37 ℃; pH=7.4;
PMH

PMH

C<sub>20</sub>H<sub>23</sub>NO<sub>5</sub>
687620-14-0

C20H23NO5

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield
With water; at 37 ℃; pH=7.4;
C<sub>24</sub>H<sub>25</sub>NO<sub>5</sub>

C24H25NO5

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield
With water; at 37 ℃; pH=7.4;
4-amino-6-chloro-benzene-1,3-disulfonyl chloride
671-89-6

4-amino-6-chloro-benzene-1,3-disulfonyl chloride

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield
With ammonium hydroxide; Heating;
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
58-93-5,8049-49-8

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Conditions
Conditions Yield

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  • LIDE PHARMACEUTICALS LIMITED
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