625-77-4

Basic information

• Product Name: DIACETAMIDE
• Synonyms: N,N-DIACETYLAMINE;BISACETYLAMINE;DIACETYLAMINE;DIACETAMIDE;Acetamide, N-acetyl-;Dicetylamine;N-Acetylacetamide;Diacetamide,98%
• CAS NO: 625-77-4
• Molecular Formula: C4H7NO2
• Molecular Weight: 101.1
• EINECS: 210-910-1
• Product Categories: Amides;Carbonyl Compounds;Organic Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 625-77-4.mol
• Article Data: 31

Chemical Properties

• Melting Point: 75.5-76.5 °C(lit.)
• Boiling Point: 222-223 °C(lit.)
• Flash Point: 101.8 °C
• Appearance: white crystalline powder or chunks
• Density: 1.3846 (rough estimate)
• Vapor Pressure: 0.0959mmHg at 25°C
• Refractive Index: 1.4340 (estimate)
• PKA: 12.15±0.46(Predicted)
• CAS DataBase Reference: DIACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DIACETAMIDE(625-77-4)
• EPA Substance Registry System: DIACETAMIDE(625-77-4)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 625-77-4(Hazardous Substances Data)

Usage

Description

DIACETAMIDE, also known as N-Acetyl Acetamide, is a white crystalline powder or chunks with useful properties for organic synthesis. It is a versatile compound that finds applications in various industries due to its unique chemical properties.

Uses

Used in Organic Synthesis:
DIACETAMIDE is used as a reagent for organic synthesis, facilitating the creation of a wide range of chemical compounds. Its ability to participate in various chemical reactions makes it a valuable component in the development of new materials and substances.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, DIACETAMIDE is used as an intermediate for the synthesis of various drugs. Its unique properties allow it to be a key component in the development of medications that target specific health conditions.
Used in Chemical Research:
DIACETAMIDE is also utilized in chemical research as a model compound to study various reaction mechanisms and to understand the behavior of similar compounds. This helps researchers in developing new synthetic methods and improving existing ones.
Used in Material Science:
In the field of material science, DIACETAMIDE is used as a building block for the development of new materials with specific properties. Its crystalline structure and chemical reactivity make it suitable for creating materials with tailored characteristics for various applications.

Purification Methods

Purify the amide by recrystallisation from MeOH [Arnett & Harrelson J Am Chem Soc 109 809 1987]. [Beilstein 2 H 181.]

InChI:InChI=1/C4H7NO2/c1-3(6)5-4(2)7/h1-2H3,(H,5,6,7)

Upstream product

• 56-23-5 tetrachloromethane 
• 1575-95-7 N-acetylbenzamide 
• 108-24-7 acetic anhydride 
• 77287-34-4 formamide 
• 590-28-3 potassium cyanate 
• 71-43-2 benzene 
• 60-35-5 acetamide 
• 100-39-0 benzyl bromide 
• 64-17-5 ethanol 
• 22534-71-0 N-acetyl-butyramide 
• 67-63-0 isopropyl alcohol 
• 463-51-4 Ketene 
• 7664-93-9 sulfuric acid 
• 62-55-5 thioacetamide 

Downstream Products

• 1124-53-4 N-cyclohexylacetamide 
• 89-52-1 o-acetylamino-benzoic acid 
• 122-28-1 N-(3-nitrophenyl)acetanilide 
• 77903-65-2 2-Methylene-3-acetyloxazoline-4,5-dione 
• 110-21-4 hydrazodicarboxamide 
• 3148-73-0 Diacetylhydrazin 
• 2719-13-3 N'-(4-Nitro-phenyl)-N-acetyl-hydrazin 
• 621-79-4 cinnamamide 
• 20069-71-0 (2E)-3-(4-nitrophenyl)acrylamide 
• 130973-09-0 (E)-3-(3-nitrophenyl)acrylamide 
• 575-36-0 1-acetamidonaphthalene 
• 15851-90-8 (E)-3-(2-chlorophenyl)acrylamide 
• 1068-57-1 acetic acid hydrazide 
• 60-35-5 acetamide 

Relevant articles and documents

Synthesis of TiO2-Ag3PO4photocatalyst material with high adsorption capacity and photocatalytic activity: application in the removal of dyes and pesticides

The photocatalytic activity of TiO2can be enhanced by coupling it with other semiconductors and the semiconductor composites may find useful application in water treatment technologies. TiO2-Ag3PO4composites wer

Heterolytic (2 e) vs Homolytic (1 e) Oxidation Reactivity: N?H versus C?H Switch in the Oxidation of Lactams by Dioxirans

Dioxiranes are powerful oxidants that can act via two different mechanisms: 1) homolytic (H abstraction and oxygen rebound) and 2) heterolytic (electrophilic oxidation). So far, it has been reported that the nature of the substrate dictates the reaction mode independently from the dioxirane employed. Herein, we report an unprecedented case in which the nature of the dioxirane rules the oxidation chemoselectivity. In particular, a switch from C?H to N?H oxidation is observed in the oxidation of lactams moving from dimethyl dioxirane (DDO) to methyl(trifluoromethyl)dioxirane (TFDO). A physical organic chemistry study, which combines the oxidation with two other dioxiranes methyl(fluoromethyl)dioxirane, MFDO, and methyl(difluoromethyl)dioxirane, DFDO, with computational studies, points to a diverse ability of the dioxiranes to either stabilize the homo or the heterolytic pathway.

N-Butylammonium carboxylates/Tf2O: Ionic liquid based systems for the synthesis of unsymmetrical imides via a Ritter-type reaction

We have developed a new method for the preparation of unsymmetrical imides using liquid carboxylate salts via a Ritter-type process. The reactions were carried out with nitriles and n-butylammonium carboxylates as ionic liquids in the presence of triflic anhydride (Tf2O) as the promoter. Mild reaction conditions, simplicity of the procedure, and proton-free conditions are the main advantages of this procedure.