6622-92-0

Basic information

• Product Name: 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE
• Synonyms: 6-HYDROXY-2,4-DIMETHYLPYRIMIDINE;4-HYDROXY-2,6-DIMETHYLPYRIMIDINE;2,4-DIMETHYL-6-HYDROXYPYRIMIDINE;2,6-DIMETHYLPYRIMIDIN-4-OL;2,6-DIMETHYL-4-PYRIMIDINO;2,6-DIMETHYL-4-PYRIMIDINOL;2,6-DIMETHYL-4-HYDROXYPYRIMIDINE;2,4-Dimethyl-6-pyrimidinol
• CAS NO: 6622-92-0
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• EINECS: 229-577-9
• Product Categories: PYRIMIDINE;APIs & Intermediate;alcohol
• Mol File: 6622-92-0.mol
• Article Data: 21

Chemical Properties

• Melting Point: 198.5-200 °C(lit.)
• Boiling Point: 230.92°C (rough estimate)
• Flash Point: 75.9 °C
• Appearance: White/Crystalline Needles
• Density: 1.1683 (rough estimate)
• Vapor Pressure: 0.301mmHg at 25°C
• Refractive Index: 1.5378 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.87±0.50(Predicted)
• BRN: 114324
• CAS DataBase Reference: 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)
• EPA Substance Registry System: 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 6622-92-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H8N2O/c1-4-3-6(9)8-5(2)7-4/h3H,1-2H3,(H,7,8,9)

Upstream product

• 86137-33-9 2,6-Dimethyl-[1,3]thiazin-4-one 
• 124-42-5 acetamidine hydrochloride 
• 141-97-9 ethyl acetoacetate 
• 1493-13-6 trifluorormethanesulfonic acid 
• 75-05-8 acetonitrile 
• 143-37-3 acetamidine 
• 603-69-0 ethyl 2-acetylacetoacetate 
• 57235-36-6 2,6-dimethylpyrimidine-4(3H)-thione 
• 88136-90-7 N-acetyl-β-mercaptocrotonamide 
• 77752-56-8 2,6-dimethyl-4-(phenylthio)pyrimidine 
• 4472-45-1 4-chloro-2,6-dimethylpyrimidine 
• 15846-25-0 ethyl ester of β-aminocrotonic acid 
• 105-53-3 diethyl malonate 
• 77752-49-9 2,6-dimethyl-4-phenylsulfonylpyrimidine 

Downstream Products

• 75-58-1 tertamethylammonium iodide 
• 199114-25-5 4-[2-[2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde 
• 1355452-88-8 2-(N-allyl-N-(2,6-dimethylpyrimidin-4-yl)amino)-N-cyclohexylbutanamide 
• 1355452-92-4 N-(4-chlorobenzyl)-2-(N-allyl-N-(2,6-dimethylpyrimidin-4-yl)amino)-3-methylbutanamide 
• 1355453-01-8 ethyl 3-(7-(1-(4-chlorobenzylcarbamoyl)-2-methylpropyl)-6,7-dihydro-2,4-dimethyl-5H-pyrrolo[2,3-d]pyrimidin-5-yl)propanoate 
• 1355452-93-5 ethyl 3-(7-(1-(cyclohexylcarbamoyl)propyl)-6,7-dihydro-2,4-dimethyl-5H-pyrrolo[2,3-d]pyrimidin-5-yl)propanoate 
• 1355453-00-7 N-cyclohexyl-2-(5,6-dihydro-2,4-dimethyl-5-(3-oxo-3-phenylpropyl)pyrrolo[2,3-d]pyrimidin-7-yl)butanamide 
• 1445787-42-7 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid 
• 69696-35-1 5-bromo-4-chloro-2,6-dimethylpyrimidine 
• 69696-37-3 5-bromo-2,4-dimethylpyrimidine 
• 1445790-87-3 methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid 
• 1445787-44-9 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoic acid 
• 1445790-91-9 methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate 

Relevant articles and documents

Ultrasound-Promoted Synthesis of 4-Pyrimidinols and Their Tosyl Derivatives

Ultrasound irradiation promoted the cyclocondensation of β-keto esters and amidines in good to excellent yields to form sixteen highly substituted 4-pyrimidinols. Tosylation of these compounds, in another ultrasound-promoted conversion, formed 4-pyrimidyl tosylates in high yields. The use of the developed protocol as an alternative route to 4-arylpyrimidines was illustrated with three examples of the Suzuki-Miyaura cross-coupling of the prepared tosylates with phenylboronic acid.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein

CYCLOPROPANE COMPOUND

A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents —CH— or a nitrogen atom, R1a and R1b each independently represent a C1-6 alkyl group and the like, R1c represents a hydrogen atom and the like, R2a, R2b, R2c and R2d each independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group and the like, R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom and the like, and R3d represents a hydrogen atom and the like.