7163-50-0 Usage
Description
4-methylbenzoylformic acid, also known as p-toluyloxyacetic acid, is a chemical compound with the molecular formula C9H8O3. It is a derivative of benzoylformic acid and belongs to the class of aromatic carboxylic acids. This white crystalline solid is sparingly soluble in water and has a melting point of around 98-100°C. It is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. Additionally, it exhibits anti-inflammatory and analgesic properties and has been studied for its potential application in the treatment of certain medical conditions. Careful handling is advised, as it can be harmful if ingested or inhaled, and may cause skin and eye irritation.
Uses
Used in Pharmaceutical Industry:
4-methylbenzoylformic acid is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical structure and reactivity.
Used in Agrochemical Industry:
4-methylbenzoylformic acid is used as a precursor in the production of agrochemicals, contributing to the development of effective pest control agents.
Used in Medical Treatment:
4-methylbenzoylformic acid is used as a potential therapeutic agent for certain medical conditions, leveraging its anti-inflammatory and analgesic properties to alleviate symptoms and improve patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 7163-50-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,6 and 3 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 7163-50:
(6*7)+(5*1)+(4*6)+(3*3)+(2*5)+(1*0)=90
90 % 10 = 0
So 7163-50-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H8O3/c1-6-2-4-7(5-3-6)8(10)9(11)12/h2-5H,1H3,(H,11,12)
7163-50-0Relevant articles and documents
Evidence for the Generation of α-Carboxy-α-hydroxy-p-xylylene from p-(Bromomethyl)mandelate by Mandelate Racemase
Lin, David T.,Powers, Vincent M.,Reynolds, Laure J.,Whitman, Christian P.,Kozarich, John W.,Kenyon, George L.
, p. 323 - 326 (1988)
-
Rapid assembly of α-ketoamides through a decarboxylative strategy of isocyanates with α-oxocarboxylic acids under mild conditions
Huang, Junjie,Liang, Baihui,Chen, Xiuwen,Liu, Yifu,Li, Yawen,Liang, Jingwen,Zhu, Weidong,Tang, Xiaodong,Li, Yibiao,Zhu, Zhongzhi
supporting information, p. 4783 - 4787 (2021/06/11)
A simple and practical method for α-ketoamide synthesis via a decarboxylative strategy of isocyanates with α-oxocarboxylic acids is described. The reaction proceeds at room temperature under mild conditions without an oxidant or an additive, showing good substrate scope and functional compatibility. Moreover, the applicability of this method was further demonstrated by the synthesis of various bioactive molecules and different application examples through a two-step one-pot operation.
Hypervalent Iodine(III)-Promoted Radical Oxidative C-H Annulation of Arylamines with α-Keto Acids
Long, Lipeng,Wang, Jieyan,Gu, Liuqing,Yang, Shiguang,Qiao, Liang,Luo, Guotian,Chen, Zhengwang
supporting information, p. 12084 - 12092 (2021/08/24)
A novel catalyst-free radical oxidative C-H annulation reaction of arylamines with α-keto acids toward benzoxazin-2-ones synthesis under mild conditions was developed. This hypervalent iodine(III)-promoted process eliminated the use of a metal catalyst or additive with high levels of functional group tolerance. Hypervalent iodine(III) was both an oxidant and a radical initiator for this reaction. The synthetic utility of this method was confirmed by the synthesis of the natural product cephalandole A.
