73908-23-3

Basic information

• Product Name: (1S)-2-bromo-1-phenyl-ethanol
• Synonyms: (1S)-2-bromo-1-phenyl-ethanol;(R)-α-(broMoMethyl)benzyl alcohol;(1R)-2-bromo-1-phenylethanol
• CAS NO: 73908-23-3
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 201.060460
• Mol File: 73908-23-3.mol
• Article Data: 141

Chemical Properties

• Boiling Point: 261.634 °C at 760 mmHg
• Flash Point: 135.55 °C
• Appearance: /
• Density: 1.504 g/cm³
• CAS DataBase Reference: (1S)-2-bromo-1-phenyl-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-2-bromo-1-phenyl-ethanol(73908-23-3)
• EPA Substance Registry System: (1S)-2-bromo-1-phenyl-ethanol(73908-23-3)

Safety Data

• Hazardous Substances Data: 73908-23-3(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 2425-28-7 2-Bromo-1-phenylethanol 
• 20780-53-4 (R)-Styrene oxide 
• 1483-82-5 phenylethynyl chloride 
• 876-27-7 4-chlorophenyl acetate 
• 70-11-1 α-bromoacetophenone 
• 22651-87-2 cyclohexanecarboxylic acid anhydride 
• 103-63-9 1-phenyl-2-bromoethane 
• 100-42-5 styrene 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 5205-07-2 3-methyl-3-buten-1-yl acetate 
• 108-05-4 vinyl acetate 
• 36567-72-3 (S)-3-hydroxy-3-phenylpropanoic acid 
• 10409-54-8 2-bromo-2-methyl-1-phenyl-propan-1-one 

Downstream Products

• 126923-26-0 (R)-2-azido-2-phenylethan-1-ol 
• 67341-01-9 (R)-N-(tert-butoxycarbonyl)phenylglycinol 
• 56613-80-0 D-2-phenylglycinol 
• 134625-72-2 (R)-2-azido-1-phenylethanol 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 247041-12-9 (S)-(+)-2-phenoxy-1-phenyl-ethanol 
• 124817-06-7 (S)-2-azido-1-phenylethanol 
• 95977-53-0 (S)-2-(N,N-dimethylamino)-2-phenylethanol 
• 34469-09-5 (R)-2-dimethylamino-1-phenyl-ethanol 
• 20780-53-4 (R)-Styrene oxide 
• 20780-54-5 (S)-styrene oxide 
• 5837-69-4 (RS)-1-bromo-2-acetoxy-2-(phenyl)ethane 
• 1445-91-6 (S)-1-phenylethanol 
• 1517-69-7 (R)-1-phenylethanol 

Relevant articles and documents

Unmasking the Hidden Carbonyl Group Using Gold(I) Catalysts and Alcohol Dehydrogenases: Design of a Thermodynamically-Driven Cascade toward Optically Active Halohydrins

A concurrent cascade combining the use of a gold(I) N-heterocyclic carbene (NHC) and an alcohol dehydrogenase (ADH) is disclosed for the synthesis of highly valuable enantiopure halohydrins in an aqueous medium and under mild reaction conditions. The meth

Supported ionic liquid-like phases as efficient solid ionic solvents for the immobilisation of alcohol dehydrogenases towards the development of stereoselective bioreductions

Polymeric materials containing ionic liquid fragments, like those found in bulk ILs, are excellent solid media for the immobilisation of biocatalysts. Herein, the entrapment of the enzymatic system formed by alcohol dehydrogenase from Rhodococcus ruber (ADH-A) overexpressed in E. coli and its coenzyme has been studied. The activity, stability and reusability of these preparations have been investigated in the bioreduction of prochiral ketones finding excellent levels of conversion and selectivity. Interestingly, the immobilised enzyme remained active and exhibited excellent stability in aqueous solutions after several recycling uses. More importantly, these biopolymer materials retained most of their activity after consecutive reaction cycles, prolonged storage and under flow conditions.

Asymmetric Catalytic Meerwein-Ponndorf-Verley Reduction of Ketones with Aluminum(III)-VANOL Catalysts

We report herein an efficient aluminum-catalyzed asymmetric MPV reduction of ketones with broad substrate scope and excellent yields and enantiomeric inductions. A variety of aromatic (both electron-poor and electron-rich) and aliphatic ketones were converted to chiral alcohols in good yields with high enantioselectivities (26 examples, 70-98percent yield and 82-99percent ee). This method operates under mild conditions (-10 °C) and low catalyst loading (1-5 mol percent). Furthermore, this process is catalyzed by the earth-abundant main-group element aluminum and employs 2-propanol as the hydride source.