74-40-8

Basic information

• Product Name: diethyl(2-phenoxyethyl)amine
• Synonyms: diethyl(2-phenoxyethyl)amine;N,N-Diethyl-2-phenoxyethanamine
• CAS NO: 74-40-8
• Molecular Formula: C₁₂H₁₉NO
• Molecular Weight: 193.28536
• EINECS: 200-809-0
• Mol File: 74-40-8.mol

Chemical Properties

• Boiling Point: 269°C at 760 mmHg
• Flash Point: 79°C
• Appearance: /
• Density: 0.951g/cm³
• Vapor Pressure: 0.00745mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: diethyl(2-phenoxyethyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl(2-phenoxyethyl)amine(74-40-8)
• EPA Substance Registry System: diethyl(2-phenoxyethyl)amine(74-40-8)

Safety Data

• Hazardous Substances Data: 74-40-8(Hazardous Substances Data)

Usage

Uses

Used in Industrial Applications:
Diethyl(2-phenoxyethyl)amine is used as a corrosion inhibitor to protect metal surfaces from corrosion and as a component in metalworking fluids to enhance the performance and longevity of these fluids.
Used in Surfactant Production:
Diethyl(2-phenoxyethyl)amine is used as a surfactant in various industries, including cosmetics and cleaning products, due to its ability to reduce surface tension and improve the solubility of other substances.
Used in Pharmaceutical Production:
Diethyl(2-phenoxyethyl)amine is used in the production of pharmaceuticals, where it may serve as an intermediate or a component in the synthesis of various drugs.
It is important to handle diethyl(2-phenoxyethyl)amine with care, as it is considered harmful if swallowed and can cause irritation to the eyes and skin. Additionally, prolonged or repeated exposure may cause damage to organs. Therefore, proper safety precautions should be taken when handling this chemical to minimize the risk of harm.

InChI:InChI=1/C12H19NO/c1-3-13(4-2)10-11-14-12-8-6-5-7-9-12/h5-9H,3-4,10-11H2,1-2H3

Upstream product

• 108-95-2 phenol 
• 100-37-8 2-(Diethylamino)ethanol 
• 105-58-8 Diethyl carbonate 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 100-36-7 N,N-diethylethylenediamine 
• 139-02-6 sodium phenoxide 
• 83698-43-5 Trifluoro-methanesulfonate1-(2-diethylamino-ethyl)-2,4,6-triphenyl-pyridinium; 
• 28317-96-6 3-phenoxypropyonic chloride 
• 109-89-7 diethylamine 
• 100-35-6 2-(diethylamino)ethyl chloride 
• 622-86-6 2-chloroethoxybenzene 
• 589-10-6 phenoxyethyl bromide 

Downstream Products

• 78250-14-3 (4-methoxy-1-phenyl-naphth-2-ylmethyl)(β-phenoxyethyl)diethylammonium bromide 
• 78250-16-5 (4-ethoxy-1-phenyl-naphth-2-ylmethyl)(β-phenoxyethyl)diethylammonium bromide 
• 21663-15-0 N,N-diethyl-N-(phenoxyethyl)amine hydrochloride 
• 137325-64-5 diethyl-methyl-(2-phenoxy-ethyl)-ammonium; iodide 
• 4386-78-1 triethyl-(2-phenoxy-ethyl)-ammonium; iodide 

Relevant articles and documents

Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols

N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.

PROCESS FOR SYNTHESIZING KETO-BENZOFURAN DERIVATIVES

The invention relates to a process for synthesizing benzofuran derivatives, in particular dronedarone of formula (D), comprising a step of Friedel-Crafts acylation starting from a sulfonamido-benzofuran ester intermediate.