7463-31-2

Basic information

• Product Name: 3'-Acetamidoacetophenone
• Synonyms: m-Acetylaminoacetophenone;3'-ACETYLACETANILIDE;3-ACETYLACETANILIDE;3'-ACETYLAMINO ACETOPHENONE;3AAAP;3-ACETAMIDEACETOPHENONE;3'-ACETAMIDOACETOPHENONE;3-ACETAMIDOACETOPHENONE
• CAS NO: 7463-31-2
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Anilines, Amides & Amines;Aromatics;Miscellaneous Reagents
• Mol File: 7463-31-2.mol
• Article Data: 35

Chemical Properties

• Melting Point: 127-130 °C
• Boiling Point: 309.12°C (rough estimate)
• Flash Point: 172.6 °C
• Appearance: cream to brown crystalline powder
• Density: 1.1607 (rough estimate)
• Vapor Pressure: 5.05E-06mmHg at 25°C
• Refractive Index: 1.5168 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 14.72±0.70(Predicted)
• BRN: 2363443
• CAS DataBase Reference: 3'-Acetamidoacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Acetamidoacetophenone(7463-31-2)
• EPA Substance Registry System: 3'-Acetamidoacetophenone(7463-31-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• Hazardous Substances Data: 7463-31-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO2/c1-7(12)9-4-3-5-10(6-9)11-8(2)13/h3-6H,1-2H3,(H,11,13)

Upstream product

• 71-55-6 1,1,1-trichloroethane 
• 103-84-4 Acetanilid 
• 64-19-7 acetic acid 
• 121-89-1 3-Nitroacetophenone 
• 19230-45-6 N-(3-iodophenyl)acetamide 
• 431-03-8 dimethylglyoxal 
• 108-22-5 Isopropenyl acetate 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 150700-53-1 C₁₀H₁₃NO₂ 
• 98-86-2 acetophenone 
• 371754-89-1 N-(3-acetyl-phenyl)-N-allyl-acetamide 
• 75-36-5 acetyl chloride 
• 201230-82-2 carbon monoxide 
• 108-24-7 acetic anhydride 

Downstream Products

• 200630-96-2 N-(3-acetylphenyl)-N-ethylacetamide 
• 158546-18-0 1-(3-(3-Acetamidophenyl)-3-(4-trifluoromethylphenoxy)propyl)piperidine, oxalate 
• 1428370-21-1 4-acetamido-2-acetylphenyl trifluoromethanesulfonate 
• 151319-34-5 zaleplon 
• 1246471-64-6 C₁₈H₁₇N₃O₂ 
• 1158910-03-2 N-(3-(1-(2-(4-chlorophenoxy)phenylamino)ethyl)phenyl)acetamide 
• 918810-76-1 N-(3-(1-Aminoethyl)phenyl)acetamide 
• 30095-56-8 1-(3-Acetylaminophenyl)-2-bromoethanone 
• 96605-61-7 N-(3-(3-(dimethylamino)acryloyl)phenyl)acetamide 
• 96605-61-7 N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]-phenyl]-acetamide 
• 325715-13-7 N-(3-acetylphenyl)-N-methylacetamide 
• 42465-64-5 2-amino-5-acetamidoacetophenone 
• 861060-96-0 acetic acid-(3-acetyl-2-amino-anilide) 
• 92642-17-6 N-(5-acetyl-2-nitrophenyl)acetamide 

Relevant articles and documents

Direct Superacid-Promoted Difluoroethylation of Aromatics

Under superacid conditions, aromatic amines are directly and regioselectively 1,1-difluoroethylated. Low temperature in situ NMR studies confirmed the presence of benzylic α-fluoronium and α-chloronium ions as key intermediates in the reaction. This method has a wide substrate scope and can be applied to the late-stage functionalization of natural alkaloids and active pharmaceutical ingredients.

Visible-light induced one-pot hydrogenation and amidation of nitroaromatics with carboxylic acids over 2D MXene-derived Pt/N-TiO2/Ti3C2

Pt nanoparticles supported on N doped titanium dioxide/titanium carbide (MXene) heterojunctions were employed as photocatalysts for the tandem reactions between aromatic nitro compounds and carboxylic acids to produce amide products. The 3%Pt/N-TiO2/Ti3C2 heterojunction was prepared by in situ grew TiO2 on Ti3C2 nanosheets and then N doped TiO2 with melamine, Pt nanoparticles with 3.3 nm mean diameter well dispersed on N-TiO2/Ti3C2. 3%Pt/N-TiO2/Ti3C2 had excellent amidation activity and chemoselectivity under visible-light irradiation. The elevated catalytic performance of 3%Pt/N-TiO2/Ti3C2 was owing to the improvement in photogenerated electron and hole separation efficiency through charge short-range directional transmission caused by the intimate contact between the TiO2 and the conductive Ti3C2. This direct hydrogenation along with amidation between nitroaromatics and carboxylic acids own actual merits in the amides produce with no harmful byproducts. In situ DRIFTS spectra verified that the amidation activation with visible light irradiation at 25 °C was much faster than heating.

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.