7463-31-2

Basic information

• Product Name: 3'-Acetamidoacetophenone
• Synonyms: m-Acetylaminoacetophenone;3'-ACETYLACETANILIDE;3-ACETYLACETANILIDE;3'-ACETYLAMINO ACETOPHENONE;3AAAP;3-ACETAMIDEACETOPHENONE;3'-ACETAMIDOACETOPHENONE;3-ACETAMIDOACETOPHENONE
• CAS NO: 7463-31-2
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Anilines, Amides & Amines;Aromatics;Miscellaneous Reagents
• Mol File: 7463-31-2.mol
• Article Data: 35

Chemical Properties

• Melting Point: 127-130 °C
• Boiling Point: 309.12°C (rough estimate)
• Flash Point: 172.6 °C
• Appearance: cream to brown crystalline powder
• Density: 1.1607 (rough estimate)
• Vapor Pressure: 5.05E-06mmHg at 25°C
• Refractive Index: 1.5168 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 14.72±0.70(Predicted)
• BRN: 2363443
• CAS DataBase Reference: 3'-Acetamidoacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Acetamidoacetophenone(7463-31-2)
• EPA Substance Registry System: 3'-Acetamidoacetophenone(7463-31-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• Hazardous Substances Data: 7463-31-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO2/c1-7(12)9-4-3-5-10(6-9)11-8(2)13/h3-6H,1-2H3,(H,11,13)

Upstream product

• 71-55-6 1,1,1-trichloroethane 
• 103-84-4 Acetanilid 
• 64-19-7 acetic acid 
• 121-89-1 3-Nitroacetophenone 
• 19230-45-6 N-(3-iodophenyl)acetamide 
• 431-03-8 dimethylglyoxal 
• 108-22-5 Isopropenyl acetate 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 150700-53-1 C₁₀H₁₃NO₂ 
• 98-86-2 acetophenone 
• 371754-89-1 N-(3-acetyl-phenyl)-N-allyl-acetamide 
• 75-36-5 acetyl chloride 
• 201230-82-2 carbon monoxide 
• 108-24-7 acetic anhydride 

Downstream Products

• 79127-41-6 1-(3-amino-4-nitrophenyl)ethan-1-one 
• 96605-61-7 N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]-phenyl]-acetamide 
• 96605-61-7 N-(3-(3-(dimethylamino)acryloyl)phenyl)acetamide 
• 200630-96-2 N-(3-acetylphenyl)-N-ethylacetamide 
• 151319-34-5 zaleplon 
• 42465-64-5 2-amino-5-acetamidoacetophenone 
• 861060-96-0 acetic acid-(3-acetyl-2-amino-anilide) 
• 92642-17-6 N-(5-acetyl-2-nitrophenyl)acetamide 
• 180343-61-7 2-nitro-5-cyanoacetophenone 
• 56079-07-3 3-acetyl-4-aminobenzonitrile 
• 16994-13-1 3-amino-6-nitroacetophenone 
• 7137-38-4 1-(3-chloro-2-nitrophenyl)ethan-1-one 
• 18640-60-3 5-chloro-2-nitroacetophenone 
• 5369-16-4 meta-iso-propyl aniline 

Relevant articles and documents

Direct para-Selective C-H Amination of Iodobenzenes: Highly Efficient Approach for the Synthesis of Diarylamines

Iodine(III)-mediated synthesis of 4-iodo-N-phenylaniline from iodobenzene has been achieved, and the reaction can proceed under mild conditions. A variety of functional groups were well tolerated, providing the corresponding products in moderate to good yields. The remaining iodine group provides an effective platform for converting the products into several valuable asymmetric diphenylamines. Most importantly, this reaction can be easily scaled up to the ten-gram scale, highlighting its synthetic utility. The mechanistic study revealed that the in situ generated aryl hypervalent iodine intermediate is the key factor to realize this para-selective C-H amination reaction.

Method for catalyzing one-pot hydrogenation and amidation of nitroaromatic hydrocarbon and carboxylic acid by visible light

The invention discloses a method for catalyzing one-pot hydrogenation and amidation reaction of nitroaromatic hydrocarbon and carboxylic acid by visible light. The method comprises the following steps: preparing Pt nanoparticles uniformly dispersed on an N-doped titanium dioxide/titanium carbide (MXene) heterojunction as a photocatalyst (3% Pt/N-TiO2/Ti3C2), and applying the catalyst to a cascade reaction of an aromatic nitro compound and carboxylic acid to prepare an amide product. The 3% Pt/N-TiO2/Ti3C2 has excellent tandem hydrogenation and amidation activity and chemical selectivity of an aromatic nitro compound and carboxylic acid under the irradiation of visible light. The excellent catalytic performance of 3% Pt/N-TiO2/Ti3C2 is attributed to the close contact of TiO2 and conductive Ti3C2, and the separation efficiency of photo-induced electrons and holes is improved through charge short-range directional transmission. The preparation method of the catalyst is simple and easy to operate, the catalyst can be used for photocatalytic efficient one-pot hydrogenation and amidation reactions, the reaction conditions are mild, and the catalyst is easy to recycle.

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.