7766-36-1

Basic information

• Product Name: N-(4-methylphenyl)prop-2-enamide
• CAS NO: 7766-36-1
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2004
• Mol File: 7766-36-1.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 321.1°C at 760 mmHg
• Flash Point: 187.4°C
• Density: 1.071g/cm³
• Vapor Pressure: 0.000305mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: N-(4-methylphenyl)prop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)prop-2-enamide(7766-36-1)
• EPA Substance Registry System: N-(4-methylphenyl)prop-2-enamide(7766-36-1)

Safety Data

• Hazardous Substances Data: 7766-36-1(Hazardous Substances Data)

Usage

General Description

N-(4-methylphenyl)prop-2-enamide is also known as N-acetyl-4-methylaniline or 4-methylacetanilide. It is a chemical compound with the molecular formula C10H11NO and is classified as an acetanilide. It is a white solid at room temperature and is commonly used in the production of pharmaceuticals, dyes, and pesticides. N-(4-methylphenyl)prop-2-enamide is also used in the synthesis of other organic compounds and as a reagent in chemical reactions. It is important to handle this chemical with care, as it may be harmful if ingested, inhaled, or if it comes into contact with the skin.

Upstream product

• 106-49-0 p-toluidine 
• 79-10-7 acrylic acid 
• 99-99-0 1-methyl-4-nitrobenzene 
• 140-88-5 ethyl acrylate 
• 624-31-7 4-tolyl iodide 
• 79-06-1 2-propenamide 
• 598-72-1 2-Bromopropionic acid 
• 590-92-1 3-Bromopropionic acid 
• 340011-42-9 N-(4-methylphenyl)-3-(phenylsulfonyl)propanamide 
• 814-68-6 acryloyl chloride 

Downstream Products

• 35600-28-3 2,3-dibromo-propionic acid p-toluidide 
• 340011-47-4 N-allyl N-(4-methylphenyl)acrylamide 
• 1256971-35-3 C₂₄H₁₉NO 
• 21690-60-8 3-ethoxy-N-p-tolylpropionamide 
• 17090-18-5 N-(4-methyl-2-nitrophenyl)acrylamide 

Relevant articles and documents

An efficient approach for the synthesis of new (±)-coixspirolactams

Coixspirolactams, spiro[oxindole-γ-lactones], are found in adlay seeds and exhibit anticancer activity. A novel synthetic methodology was developed to enable an easy access to (±)-coixspirolactam A and a large number of new coixspirolactams in excellent overall yields. The exquisite exploitation of formamide reactivity was essential for the construction of oxindole and lactone scaffolds. This journal is

Rh(i)-Catalyzed regioselective arylcarboxylation of acrylamides with arylboronic acids and CO2

The first Rh(i)-catalyzed regioselective arylcarboxylation of electron-deficient acrylamides with arylboronic acids under atmospheric pressure of CO2 has been developed. A range of acrylamides and arylboronic acids were compatible with this reaction under redox-neutral conditions, leading to a series of malonate derivatives that are versatile building blocks in organic syntheses.

Systematic study of the glutathione (GSH) reactivity of N-arylacrylamides: 1. Effects of aryl substitution

Success in the design of targeted covalent inhibitors depends in part on a knowledge of the factors influencing electrophile reactivity. In an effort to further develop an understanding of structure-reactivity relationships among N-arylacrylamides, we determined glutathione (GSH) reaction rates for a family of N-arylacrylamides independently substituted at ortho-, meta-, and para-positions with 11 different groups common to inhibitor design. We find that substituent effects on reaction rates show a linear Hammett correlation for ortho-, meta-, and para-substitution. In addition, we note a correlation between 1H and 13C NMR chemical shifts of the acrylamide with GSH reaction rates, suggesting that NMR chemical shifts may be a convenient surrogate measure of relative acrylamide reactivity. Density functional theory calculations reveal a correlation between computed activation parameters and experimentally determined reaction rates, validating the use of such methodology for the screening of synthetic candidates in a prospective fashion.