84793-07-7

Basic information

• Product Name: Fmoc-L-Glutamic acid 1-tert-butyl ester
• Synonyms: L-GLUTAMIC ACID, N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-, 1-(1,1-DIMETHYLETHYL) ESTER;N-α-Fmoc-L-glutamic acid α-tert butyl ester;Fmoc glutamic acid butyl ester;(S)-4-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-5-(tert-butoxy)-5-oxopentanoic acid;N-FMoc-L-glutaMic acid 1-tert-butyl ester;Fmoc-L-glutamic acid α-tert-butyl ester≥ 98% (HPLC, Chiral purity);N-FMOC-L-GLUTAMIC ACID-1-T-BUTYL ESTER;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMIC ACID ALPHA-T-BUTYL ESTER
• CAS NO: 84793-07-7
• Molecular Formula: C₂₄H₂₇NO₆
• Molecular Weight: 425.47
• Product Categories: Glutamic acid [Glu, E]
• Mol File: 84793-07-7.mol

Chemical Properties

• Melting Point: 78-80 °C
• Boiling Point: 638.1 °C at 760 mmHg
• Flash Point: 339.7 °C
• Appearance: /
• Density: 1.232 g/cm³
• Storage Temp.: Store at RT.
• PKA: 4.46±0.10(Predicted)
• CAS DataBase Reference: Fmoc-L-Glutamic acid 1-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-L-Glutamic acid 1-tert-butyl ester(84793-07-7)
• EPA Substance Registry System: Fmoc-L-Glutamic acid 1-tert-butyl ester(84793-07-7)

Safety Data

• Hazardous Substances Data: 84793-07-7(Hazardous Substances Data)

Upstream product

• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 56-86-0 L-glutamic acid 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 115-11-7 isobutene 
• 157108-58-2 (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid 5-benzyl ester 1-tert-butyl ester 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 123639-61-2 Fmoc-L-glutamic acid-g-benzyl ester 

Downstream Products

• 200616-38-2 (2S)-N₂-(9-fluorenylmethyloxycarbonyl)-glutamic acid α-tert-butyl ester γ-N-hydroxysuccinimide ester 
• 501000-00-6 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{2-[(4-methoxy-phenyl)-diphenyl-methylsulfanyl]-ethylcarbamoyl}-butyric acid tert-butyl ester 
• 844486-60-8 2-{4-tert-butoxycarbonyl-2-[4-tert-butoxycarbonyl-2-(4-tert-butoxycarbonyl-4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid 5-tert-butyl ester 
• 1116-22-9 γ-L-glutamyl-L-glutamic acid 
• 105644-04-0 γ-L-glutamyl-γ-L-glutamyl-L-cysteinylglycine 
• 947538-46-7 C₄₉H₅₄N₂O₅S 
• 936952-28-2 C₄₀H₆₂N₄O₁₃S₂ 
• 936952-02-2 C₁₉H₂₆N₄O₉S 

Relevant articles and documents

Preparation method of N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid

The invention provides a preparation method of N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid. The preparation method mainly solves the technical problems of complexity, long period, high cost, and low yield of an original process, and comprises the following steps: (1) preparing N-fluorenylmethoxycarbonyl-L-glutamic acid; (2) preparing N-fluorenylmethoxycarbonyl-L-glutamic acid-1-benzyl ester; (3) preparing S-triphenylmethyl cysteamine; (4) preparing N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid-alpha-benzyl ester; and (5) preparing N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid. The method is rapid, high in yield and simple in separation and purification, and the used solvent is environment-friendly and is suitable for mass production.

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