85-43-8

Basic information

• Product Name: CIS-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; >98%
• Synonyms: 1,2,3,6-Tetrahydrophthalic acid anhydride;1,2,3,6-tetrahydrophthalicacidanhydride;1,2,3,6-tetrahydro-phthalicanhydrid;1,2,3,6-tetrahydrophthalicanhydride[qr];1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-, cis-;1,3-isobenzofurandione,3a,4,7,7a-tetrahydro-[qr];3a,4,7,7a-tetrahydro-1,3-benzofurandione;3a,4,7,7a-tetrahydro-3-isobenzofurandione
• CAS NO: 85-43-8
• Molecular Formula: C₈H₈O₃
• Molecular Weight: 152.14732
• EINECS: 201-605-4
• Product Categories: Pyridines
• Mol File: 85-43-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 101-102°C
• Boiling Point: 195°C 5mm
• Flash Point: 157°C
• Appearance: /
• Density: 1,375 g/cm3
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.4810 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: 3.84[at 20 ℃]
• Water Solubility: REACTS
• CAS DataBase Reference: CIS-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; >98%(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; >98%(85-43-8)
• EPA Substance Registry System: CIS-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; >98%(85-43-8)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: 41-42/43-52/53
• Safety Statements: 26-36/37/39
• RIDADR: 2698
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 85-43-8(Hazardous Substances Data)

Usage

Uses

Chemical intermediate for light-colored alkyds, polyesters, plasticizers, and adhesives; intermediate for pesticides; hardener for resins.

Definition

ChEBI: 1,2,3,6-tetrahydrophthalic anhydride is a cyclic dicarboxylic anhydride that is 1,3,3a,4,7,7a-hexahydro-2-benzofuran carrying oxo groups at positions 1 and 3. It is a cyclic dicarboxylic anhydride and a tetrahydrofurandione.

General Description

Clear colorless to light yellow slight viscous liquid. Highly toxic and a strong irritant to skin, eyes and mucous membranes. Corrosive to skin and metal. Used in making polyester, alkyd resins, and plasticizers.

Air & Water Reactions

Reacts exothermically with water to form memtetrahydrophthalic acid.

Reactivity Profile

CIS-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; >98% is combustible. Reacts with oxidizers. Reacts exothermically with water. These reactions are usually slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Flammability and Explosibility

Nonflammable

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. A corrosive irritant to skin, eyes, and mucous membranes. Combustible when exposed to heat or flame. Will react with water or steam to produce heat; can react with oxidizing materials. To fight fre, use water, foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ANHYDRIDES.

InChI:InChI=1/C8H8O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1,3,5-6H,2,4H2

Upstream product

• 108-31-6 maleic anhydride 
• 590-19-2 2,3-dimethylbutene 
• 106-99-0 buta-1,3-diene 
• 17673-68-6 dimethyl trans-cyclohex-4-ene-1,2-dicarboxylate 
• 4841-84-3 dimethyl cis-1,2,3,6-tetrahydrophthalate 
• 88-98-2 trans-cyclohex-4-ene-1,2-dicarboxylic acid 
• 88-98-2 cyclohex-4-ene-1,2-dicarboxylic acid 
• 95-47-6 o-xylene 
• 7500-55-2 dimethyl cyclohex-4-ene-1,2-dicarboxylate 
• 77-79-2 3-Sulfolene 

Downstream Products

• 100171-79-7 6β-((1Ξ)-ξ-6-carboxy-cyclohex-3-enecarbonylamino)-penicillanic acid 
• 19692-02-5 6-thiazol-2-ylcarbamoyl-cyclohex-3-enecarboxylic acid 
• 39214-27-2 1,2,3,6-Tetrahydrophthalsaeure-bis-dimethylamid 
• 40634-95-5 trimethylsilyl cis-2-isocyanato-4-cyclohex-1-ene carboxylate 
• 1703-58-8 racem.-butane-1,2,3,4-tetracarboxylic acid 
• 129760-94-7 5,10-Dihydro-4-ethyl-2-phenylpyrazolo<1,5-a><1,3>-7-cyclohexendiazepin-5,10-dione 
• 87024-43-9 (Z)-10-Nitro-8-phenyl-1,4,4a,6,13,14a-hexahydro-6,7,13-triaza-dibenzo[a,f]cyclodecene-5,14-dione 
• 136606-69-4 C₃₄H₃₆O₁₂ 
• 87024-42-8 (Z)-10-Bromo-8-phenyl-1,4,4a,6,13,14a-hexahydro-6,7,13-triaza-dibenzo[a,f]cyclodecene-5,14-dione 
• 136606-66-1 Cyclohex-4-ene-1,2-dicarboxylic acid mono-(2,6,13,16,19-pentaoxa-tricyclo[18.4.0.0^7,12]tetracosa-1⁽²⁴⁾,7,9,11,20,22-hexaen-4-yl) ester 
• 89446-98-0 3-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-isoindol-2-yl)-benzoic acid 
• 90619-37-7 2-[3-(4-p-Tolyl-piperazin-1-yl)-propyl]-3a,4,7,7a-tetrahydro-isoindole-1,3-dione; hydrochloride 
• 90619-38-8 2-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-isoindole-1,3-dione; hydrochloride 
• 80575-39-9 6-[5-(5-Oxo-2,5-dihydro-furan-3-yl)-2,3-dihydro-indole-1-carbonyl]-cyclohex-3-enecarboxylic acid 

Relevant articles and documents

Method for preparing butane tetracarboxylic dianhydride

The invention discloses a method for preparing butane tetracarboxylic dianhydride, and belongs to the field of fine chemical preparation methods. The method comprises the following steps: using maleicanhydride and 1,3-butadiene as starting materials to synthesize tetrahydrophthalic anhydride as an intermediate product through a 1,4-addition reaction in a high temperature molten state; subjectingtetrahydrophthalic anhydride to hydrolysis, ozone oxidation, hydrogen peroxide oxidation reaction to obtain butane tetracarboxylic acid as an intermediate product; using acetic anhydride or propionicanhydride as a dehydrating agent, and subjecting the butane tetracarboxylic acid to synthesize butane tetracarboxylic dianhydride through dehydration closed-ring. Compared with the traditional process, the method has the advantages of mild reaction conditions, high product purity, high yield, and no pollution, and is suitable for large-scale industrial production.

CATALYST FOR ALKYLATION AND PROCESS FOR PRODUCING ALKYLAROMATIC HYDROCARBON COMPOUND USING THE CATALYST

A catalyst for alkylation contains an inorganic structural material having an ion-exchange ability and a metal ion having a valency of 2 or more. The metal ion is supported on the inorganic structural material. The inorganic structural material is preferably a zeolite. The metal ion is preferably a lanthanide metal. The catalyst for alkylation imparts industrially satisfiable activity and selectivity and can be readily separated, collected and recycled. Furthermore, the process for producing an alkylaromatic hydrocarbon compound includes reacting an aromatic hydrocarbon compound and a compound having an unsaturated bond in the presence of the catalyst for alkylation.

Synthetic approach to cis and trans-decalins via Diels - Alder reaction and ring-closing metathesis as key steps: Further extension to dioxapropellane derivative by ring-closing metathesis

9,10-Substituted cis and trans-decalins were synthesized by a simple route using the Diels-Alder reaction and ring-closing metathesis (RCM) as key steps. Later, the cis-decalin system has been extended to 3,8-dioxa[8.4.4]propellane derivative by RCM sequence as a key step. Copyright