56124-48-2

Basic information

• Product Name: Tetrahydrophthalic acid Methyl ester
• Synonyms: Tetrahydrophthalic acid Methyl ester;6-(methoxycarbonyl)cyclohex-3-enecarboxylic acid;4-Cyclohexene-1,2-dicarboxylic acid, monomethyl ester
• CAS NO: 56124-48-2
• Molecular Formula: C₉H₁₂O₄
• Molecular Weight: 184.18918
• Mol File: 56124-48-2.mol
• Article Data: 76

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Tetrahydrophthalic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydrophthalic acid Methyl ester(56124-48-2)
• EPA Substance Registry System: Tetrahydrophthalic acid Methyl ester(56124-48-2)

Safety Data

• Hazardous Substances Data: 56124-48-2(Hazardous Substances Data)

Usage

General Description

Tetrahydrophthalic acid methyl ester, also known as methyl tetrahydrophthalate, is a chemical compound that is commonly used as a solvent in various industrial applications, such as in the production of paints, varnishes, and adhesives. It is also utilized as a plasticizer and in the synthesis of other chemicals. Tetrahydrophthalic acid methyl ester is a clear, colorless liquid with a mild, fruity odor and is considered to be relatively low in toxicity. It is flammable and should be handled with care, following proper safety protocols for handling and storage.

Upstream product

• 7500-55-2 dimethyl cyclohex-4-ene-1,2-dicarboxylate 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 88-98-2 trans-cyclohex-4-ene-1,2-dicarboxylic acid 
• 2305-26-2 cis-1,2,3,6-tetrahydrophthalic acid 
• 85-43-8 1,2,3,6-Tetrahydrophthalic anhydride 
• 93603-11-3 1-methyl hydrogen 1,2-cis-1,2-cyclohex-4-ene dicarboxylate 
• 4841-84-3 dimethyl cis-1,2,3,6-tetrahydrophthalate 
• 88-20-0 o-toluenesulfonic acid 

Downstream Products

• 150024-72-9 dimethyl (R,R)-(-)-trans-1,2-cyclohex-4-ene-1,2-dicarboxylate 
• 171231-24-6 (1R,2R)-2-Hydroxymethyl-cyclohexanecarboxylic acid methyl ester 
• 84073-88-1 2-Formyl-5-(2-methyl-[1,3]dithiolan-2-yl)-cyclohexanecarboxylic acid methyl ester 
• 102508-02-1 (1S,6R)-6-benzyloxycarbonylaminocyclohex-3-enecarboxylic acid 
• 1321925-48-7 methyl (1S,2R,4S,5S)-2-(tert-butoxycarbonylamino)-5-(2-chloroethoxy)-4-hydroxycyclohexanecarboxylate 
• 1321925-38-5 methyl (1S,2R,4R,5R)-4-(2-azidoethoxy)-2-(tert-butoxycarbonylamino)-5-(tert-butyldimethylsilanyloxy)cyclohexanecarboxylate 
• 1321925-52-3 methyl (1S,2R,4R,5R)-2-(tert-butoxycarbonylamino)-4-(2-chloroethoxy)-5-(tert-butyldimethylsilanyloxy)cyclohexanecarboxylate 
• 1321925-50-1 methyl (1S,2R,4S,5S)-2-(tert-butoxycarbonylamino)-5-(2-chloroethoxy)-4-(tert-butyldimethylsilanyloxy)cyclohexanecarboxylate 
• 1321925-49-8 methyl (1S,2R,4R,5R)-2-(tert-butoxycarbonylamino)-4-(2-chloroethoxy)-5-hydroxycyclohexanecarboxylate 
• 1321925-40-9 methyl (1S,2R)-2-(tert-butoxycarbonylamino)cyclohex-4-enecarboxylate 
• 1321925-51-2 methyl (1S,2R,4S,5S)-5-(2-azidoethoxy)-2-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilanyloxy)cyclohexancarboxylate 
• 1265882-93-6 (1R,2R,4R)-2-(hex-5-enylmethylcarbamoyl)-5-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane carboxylic acid benzyl ester 
• 1265882-92-5 (1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 
• 1265882-91-4 (1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)-quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester 

Relevant articles and documents

The New Catalyst System: Chloramphenicol Base and Organic Acid Co-catalyzed Enantioselective Alcoholysis of meso-Anhydride

In this study, the synergistic catalytic strategy was developed, which chloramphenicol base and organic acid were used in the same system, the optimal enantioselectivity value and yield (96% yield; 65% ee) was achieved using the binary co-catalyst in the asymmetric alcoholysis reaction of mesoanhydride. Moreover, a hypothetical intermediate between the substrate and the binary co-catalyst which is responsible for stereochemistry control in this catalytic reaction was proposed. In addition, the results of molecular mechanics calculations also have shed light on the corresponding catalytic mechanism.

Novel amide-functionalized chloramphenicol base bifunctional organocatalysts for enantioselective alcoholysis of meso-cyclic anhydrides

A family of novel chloramphenicol base-amide organocatalysts possessing a NH functionality at C-1 position as monodentate hydrogen bond donor were developed and evaluated for enantioselective organocatalytic alcoholysis of meso-cyclic anhydrides. These structural diversified organocatalysts were found to induce high enantioselectivity in alcoholysis of anhydrides and was successfully applied to the asymmetric synthesis of (S)-GABOB.

Reversible Switching and Recycling of Adaptable Organic Microgel Catalysts (Microgelzymes) for Asymmetric Organocatalytic Desymmetrization

Adaptable enzyme-mimetic catalysts based on temperature-responsive polymer microgels (microgelzymes) have been developed. By a simple change in the temperature, a microgel catalyst can be reversibly switched into its soluble or precipitated form, thus com