99-56-9Relevant articles and documents
ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I' PATHWAY AND METHODS OF USE THEREOF
-
Page/Page column 55, (2020/03/05)
The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.
Excellent photocatalytic reduction of nitroarenes to aminoarenes by BiVO4 nanoparticles grafted on reduced graphene oxide (rGO/BiVO4)
Azad, Roya,Bezaatpour, Abolfazl,Amiri, Mandana,Eskandari, Habibollah,Nouhi, Sima,Taffa, Dereje H.,Wark, Michael,Boukherroub, Rabah,Szunerits, Sabine
, (2019/07/03)
A novel heterogeneous composite material based on reduced graphene oxide (rGO) and bismuth vanadate (BiVO4) was prepared and characterized by various techniques such as powder XRD, HRTEM, EADX, UV–Vis-DRS, FT-IR, Raman, BET and XPS analyses. The characterization results reveal that the rGO well decorated by BiVO4. The electrochemical impedance spectroscopy (EIS) shows the increasing of charge transfer of rGO/BiVO4 in presence of light irradiation. In this research, the pure BiVO4 and rGO/BiVO4 composite have been explored for photocatalytic reduction of nitroarenes. Among the prepared nanocomposites, rGO loaded with 10% BiVO4 catalyst (noted as rGO/BiVO4–10%) shows the best performance for the photo-reduction of various nitroaromatic molecules to their corresponding amine compounds under visible-light irradiation at room temperature. The catalyst exhibited in particular excellent photocatalytic activity for the conversion of 1,4-dinitrobenzene to 4-nitroanilline (100% conversion) in 20?min, 4-chloronitrobenzene to 4-chloroaniline and 2-nitrophenol to 2-aminophenol (100% conversion) in only 30?min. In addition, the conversion of 4-bromonitrobenzene, 4-iodonitrobenzene to their corresponding amine compounds (100% conversion) was achieved in 60?min. The catalyst was recovered for several times and reused without decreasing of its efficiency.
1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation
Venter, Jana,Perez, Concepción,van Otterlo, Willem A.L.,Martínez, Ana,Blackie, Margaret A.L.
, p. 1597 - 1600 (2019/05/02)
Glycogen synthase kinase 3 (GSK-3)has become known for its multifactorial involvement in the pathogenesis of Alzheimer's disease. In this study, a benzothiazole- and benzimidazole set of 1-aryl-3-(4-methoxybenzyl)ureas were synthesised as proposed Cys199-targeted covalent inhibitors of GSK-3β, through the incorporation of an electrophilic warhead onto their ring scaffolds. The nitrile-substituted benzimidazolylurea 2b (IC50 = 0.086 ± 0.023 μM)and halomethylketone-substituted benzimidazolylurea 9b (IC50 = 0.13 ± 0.060 μM)displayed high GSK-3β inhibitory activity, in comparison to reference inhibitor AR-A014418 (1, IC50 = 0.072 ± 0.043)in our assay. The results suggest further investigation of 2b and 9b as potential covalent inhibitors of GSK-3β, since a targeted interaction might provide improved kinase-selectivity.