is a kind of antibiotic API. This chemical is semi-synthetic derivative of which consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). There are some basic informations about this crude drug: (1)EINECS No.: 274-536-0; (2)Molecular formula: C₄₈H₇₄O₁₄; (3)Product: Ivermectin; (4)CAS: ; (5)Appearance: White or yellowish-white crystalline powder.

Ivermectin is a broad-spectrum antiparasitic avermectin medicine. It is a broad-spectrum antiparasitic agent. The main concern is neurotoxicity, which in most mammalian species may manifest as CNS depression, and consequent ataxia, as might be expected from potentiation of inhibitory GABA-ergic synapses. Dogs with defects in the P-glycoprotein gene can be severely poisoned by ivermectin.

This chemical is traditionally used against worms. Ivermectin, under the brand name Mectizan, is currently being used to help eliminate river blindness (onchocerciasis) in the Americas and stop transmission of lymphatic filariasis and onchocerciasis around the world. Currently, large amounts of ivermectin are donated by Merck to fight river blindness in countries that are unable to afford the drug. The disease is endemic in 30 African countries, 6 Latin American countries and Yemen, according to studies conducted by the World Health Organization. The drug rapidly kills microfilariae, but not the adult worms. A single oral dose of ivermectin, taken annually for the 10-15 year life span of the adult worms, is all that is needed to protect the individual from onchocerciasis.