Welcome to LookChem.com Sign In | Join Free

Details

Home > Chemical Encyclopedia > Basic Chemical > Chemical Reaction >
 Aciclovir
  • Aciclovir
  • (brand name Alti- or Avirax), with its CAS registry number , has its IUPAC name of 2-amino-9-[(2-hydroxyethoxy)methyl]-6,9-dihydro-3H-purin-6-one. This chemical belongs to the classes of s and Purine Derivatives. Besides, it is a guanosine analog that acts as an antimetabolite and is especially used against herpes.

    Following are the detailed information of Aciclovir:
    (1). Indication Aciclovir: For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
    (2). Pharmacodynamics Aciclovir: Aciclovir (INN) or acyclovir (USAN, former BAN) is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of aciclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
    (3). Mechanism of action: Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts aciclovir to the aciclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Aciclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.
    (4). Absorption Aciclovir: Oral: bioavailability 10 to 20%


    Prev: BioAmber opens succinic acid facility in Sarnia, Canada
    Next: Double Displacement Reactions
  • Back】【Close 】【Print】【Add to favorite
High quality aciclovir cas 59277-89-3 best price59277-89-3SJZ THLD IMP & EXP CO LTDInquiry
High Content Natural Extract Aciclovir HACCP manufacturer59277-89-3Xi'an Xszo Chem Co., Ltd.Inquiry
Aciclovir59277-89-3HANGZHOU CLAKE BIOTECH CO.,LTDInquiry
99% Aciclovir Powder cas 59277-89-359277-89-3Hubei Vanz Pharm Co.,LtdInquiry
Acycloguanosine59277-89-3Henan Sinotech Import&Export CorporationInquiry
Hot sales Aciclovir CAS 59277-89-359277-89-3Guangdong Juda Chemical Industrial Co.,LimitedInquiry
afine+ACICLOVIR59277-89-3Afine Chemicals LimitedInquiry
59277-89-3Hangzhou J&H Chemical Co., Ltd.Inquiry
Acyclovir59277-89-3Wuhan ZeShanCheng Biomedical Technology Co., Ltd.Inquiry
99% up by HPLC Aciclovir sodium 69657-51-869657-51-8Sinoway Industrial Co., Ltd.Inquiry
Periodic Table
    Hot Products