Dowd-Beckwith Ring Expansion Reaction

A. L. J. Beckwith et al., J. Am. Chem. Soc. 110, 2565 (1988); P. Dowd, S. C. Choi, Tetrahedron 45, 77 (1989).

Free radical mediated ring expansions of haloalkyl β-ketoesters:



Synthetic application: M. G. Banwell, J. M. Cameron, Tetrahedron Letters 37, 525 (1996); C. Wang et al., Tetrahedron 54, 8355 (1998).