Friedel-Crafts Reaction

C. Friedel, J. M. Crafts, Compt. Rend. 84, 1392, 1450 (1877).

The alkylation or acylation of aromatic compounds catalyzed by aluminum chloride or other Lewis acids:



Reviews: C. C. Price, Org. React. 3, 1 (1946); G. A. Olah, Friedel-Crafts and Related Reactions, vol. 1-4 (Interscience, New York, 1963-1965); J. K. Groves, Chem. Soc. Rev. 1, 73 (1972); H. Heaney, Comp. Org. Syn. 2, 733-752, 753-768 (1991); 3, 293-339. Aliphatic version: S. C. Eyley, ibid. 2, 707-731. Intramolecular reactions: H.-J. Knölker, Angew. Chem. Int. Ed. 38, 2583 (1999); M.-C. P. Yeh et al., J. Organometal. Chem. 599, 128 (2000); C.-L. Kao et al., Tetrahedron Letters 41, 2207 (2000). Modified conditions: U. Bierman, J. O. Metzger, Angew. Chem. Int. Ed. 38, 3675 (1999). Cf. Darzens-Nenitzescu Synthesis of Ketones; Haworth Synthesis; Nencki Reaction.