Dötz Reaction

K. H. Dötz, Angew. Chem. Int. Ed. 14, 644 (1975).

Three component cyclization of an aromatic or vinylic alkoxy pentacarbonyl chromium carbene complex, an alkyne, and carbon monoxide, generating a Cr(CO)₃ coordinated phenol:



Solvent effects: K. S. Chan et al., J. Organometal. Chem. 334, 9 (1987). Methods development: S. Chamberlin et al., Tetrahedron 49, 5531 (1993); S. Chamberlin, W. D. Wulff, J. Org. Chem. 59, 3047 (1994). Synthetic applications: W. D. Wulff et al., J. Am. Chem. Soc. 110, 7419 (1988); D. L. Boger, I. C. Jacobson, J. Org. Chem. 56, 2115 (1991). Review: K. H. Dötz, New J. Chem. 14, 433-445 (1990).