Hantzsch Pyrrole Synthesis

A. Hantzsch, Ber. 23, 1474 (1890).

Formation of pyrrole derivatives from α-chloromethyl ketones, β-keto esters and ammonia or amines:



R. Elderfield, T. N. Dodd, Jr., Heterocyclic Compounds 1, 132 (1950); A. H. Corwin, ibid. 290; M. W. Roomi, S. F. MacDonald, Can. J. Chem. 48, 1689 (1970); K. Kirschke et al., J. Prakt. Chem. 332, 143 (1990); A. W. Trautwein et al., Bioorg. Med. Chem. Lett. 8, 2381 (1998). Cf. Feist-Bénary Synthesis; Knorr Pyrrole Synthesis; Paal-Knorr Pyrrole Synthesis.