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 Hinsberg Oxindole and Oxiquinoline Synthesis
  • Hinsberg Oxindole and Oxiquinoline Synthesis
  • Hinsberg and Oxiquinoline Synthesis

    O. Hinsberg, Ber. 21, 110 (1888); 25, 2545 (1892); 41, 1367 (1908).

    Formation of oxindoles from secondary aryl amines and the acid addition compound of glyoxal; primary aryl amines give glycine or glycinamide derivatives:



    O. Hinsberg, J. Rosenzweig, ibid. 27, 3253 (1894); C. Hollins, Synthesis of Ring Compounds (London, 1924) p 112; H. Burton, J. Chem. Soc. 1932, 546; P. L. Julian et al., Heterocyclic Compounds 3, 139 (1952). Mechanistic study: M. I. Abasolo et al., J. Heterocyclic Chem. 29, 1279 (1992). Applications: M. I. Abasolo et al., ibid. 27, 157 (1990); G. A. Rodrigo et al., ibid. 34, 505 (1997). Cf. Stollé Synthesis.


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