Purdie Methylation (Irvine-Purdie Methylation)

T. Purdie, J. C. Irvine, J. Chem. Soc. 83, 1021 (1903).

Exhaustive methylation of a methyl glycoside by repeated treatment with methyl iodide and silver oxide, followed by hydrolysis of the pentamethyl ether with dilute acid to yield the anomeric hydroxyl group:



C. C. Barker, et al., ibid. 1946, 753; E. J. Bourne, S. Peat, Advan. Carbohyd. Chem. 5, 146 (1950); W. Pigman, The Carbohydrates (New York, 1957) p 370; P. V. Kovac et al., Carbohyd. Res. 58, 327 (1977). Cf. Haworth Methylation.