Mukaiyama-Michael Reaction

K. Narasaka et al., Bull. Chem. Soc. Japan 49, 779 (1976).

Formation of 1,5-dicarbonyl compounds by reaction of ketene silyl acetals with α,β-unsaturated ketones and esters:



T. Mukaiyama, S. Kobayashi, Heterocycles 25, 245 (1987). Enhanced diasteroselectivity: J. Otera et al., Tetrahedron 52, 9409 (1996); in tandem-aldol reaction: N. Giuseppone et al., Tetrahedron Letters 39, 7874 (1998). Synthetic application: H. Paulsen et al., Angew. Chem. Int. Ed. 38, 3373 (1999).